Discovery of Truncated Cyclic Peptides Targeting an Induced-Fit Pocket on PCSK9.

Autor: Grosche P; Novartis Biomedical Research, Fabrikstrasse 2, Novartis Campus, 4056, Basel, Switzerland., Flyer AN; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Gattlen R; Novartis Biomedical Research, Fabrikstrasse 2, Novartis Campus, 4056, Basel, Switzerland., Xu M; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Golosov AA; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Vera V; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Pickett S; Novartis Biomedical Research, Fabrikstrasse 2, Novartis Campus, 4056, Basel, Switzerland., Brousseau ME; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Chopra R; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Clairmont KB; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Koch A; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Liu E; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Reid P; PeptiDream, Inc., KOL Building, Room 405, 4-6-1 Komaba, Meguro-Ku, Tokyo, 153-8904, Japan., Perry L; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Yang L; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Yang Q; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Monovich LG; Novartis Biomedical Research, 22 Windsor Street and 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Dec 02; Vol. 19 (23), pp. e202400208. Date of Electronic Publication: 2024 Oct 22.

ChemInform Abstract: Conformationally Restricted Arginine Analogues

Autor: T. R. Webb, C. Eigenbrot

Publikováno v: ChemInform. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5d73ed6f9973187bb60a8d0c5334d52
https://doi.org/10.1002/chin.199141233

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Katie Hine

Autor: Daily Record Staff

Publikováno v: Daily Record, The (Baltimore, MD). 08/22/2024.

The tissue factor region that interacts with substrates factor IX and Factor X

Autor: D, Kirchhofer, M T, Lipari, P, Moran, C, Eigenbrot, R F, Kelley

Publikováno v: Biochemistry. 39(25)

The enzymatic activity of coagulation factor VIIa is controlled by its cellular cofactor tissue factor (TF). TF binds factor VIIa with high affinity and, in addition, participates in substrate interaction through its C-terminal fibronectin type III d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1f95ffe85684ef3b8c690bedc55c3ef
https://pubmed.ncbi.nlm.nih.gov/10858285