Zobrazeno 1 - 10
of 21
pro vyhledávání: '"C E Seidman"'
Autor:
D Reichart, E L Lindberg, H Maatz, A Miranda, A Viveiros, N Shvetsov, M Lee, K Kanemaru, H Milting, M Noseda, G Oudit, M Heinig, J G Seidman, N Huebner, C E Seidman
Publikováno v:
European Heart Journal. 43
Pathogenic variants in genes that cause dilated (DCM) and arrhythmogenic cardiomyopathies (ACM) convey high risks for the development of heart failure (HF) through unknown mechanisms. Using single nucleus RNA sequencing (snRNAseq), we characterized t
Autor:
J A Encinas, M B Lees, R A Sobel, C Symonowicz, J M Greer, C L Shovlin, H L Weiner, C E Seidman, J G Seidman, V K Kuchroo
Publikováno v:
The Journal of Immunology. 157:2186-2192
Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is a T cell-mediated autoimmune disease that can be induced in experimental animals by immunization with myelin Ags. Inbred strains of mice show varying degrees of
Autor:
C, Semsarian, C E, Seidman
Publikováno v:
Internal medicine journal. 31(1)
When Watson and Crick proposed the double helix model for DNA structure in a 2 page Nature article in 1953, no one could have predicted the enormous impact this finding would have on the study of human disease. Over the last decade in particular, maj
Publikováno v:
Journal of lipid research. 41(4)
We previously reported that a eucaloric, low fat, liquid formula diet enriched in simple carbohydrate markedly increased the synthesis of fatty acids in lean volunteers. To examine the diet sensitivity of obese subjects, 7 obese and 12 lean volunteer
Autor:
C I, Berul, M E, Christe, M J, Aronovitz, C T, Maguire, C E, Seidman, J G, Seidman, M E, Mendelsohn
Publikováno v:
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2(1)
Genetically-manipulated mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+) display a phenotype characteristic of familial hypertrophic cardiomyopathy (FHC). Male and female (30 +/- 8 week old) heterozygous alpha-M
Publikováno v:
Journal of lipid research. 39(12)
A possible relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness was examined in 18 normal subjects fed low fat low cholesterol, high fat low cholesterol, and high fat high cholesterol diets. For the grou
Autor:
B J, Maron, J H, Moller, C E, Seidman, G M, Vincent, H C, Dietz, A J, Moss, H M, Sondheimer, R E, Pyeritz, G, McGee, A E, Epstein
Publikováno v:
Circulation. 98(14)
Autor:
C, Ye, C L, Ho-Pao, M, Kanazirska, S, Quinn, K, Rogers, C E, Seidman, J G, Seidman, E M, Brown, P M, Vassilev
Publikováno v:
Journal of neuroscience research. 47(5)
The amyloid-beta peptides (A beta) are produced in excess in Alzheimer's disease (AD) and may contribute to neuronal dysfunction and degeneration. This study provides strong evidence for a novel cellular target for the actions of A beta, the phosphol
Publikováno v:
The Journal of clinical endocrinology and metabolism. 82(1)
Isolated GnRH deficiency is a heritable condition characterized by a functional deficit in GnRH secretion. Familial cases with different modes of inheritance have been described, and the gene responsible for the X-linked form (KAL-1) has been identif
Autor:
C T, Basson, D R, Bachinsky, R C, Lin, T, Levi, J A, Elkins, J, Soults, D, Grayzel, E, Kroumpouzou, T A, Traill, J, Leblanc-Straceski, B, Renault, R, Kucherlapati, J G, Seidman, C E, Seidman
Publikováno v:
Nature genetics. 15(1)
Holt-Oram syndrome is characterized by upper limb malformations and cardiac septation defects. Here, we demonstrate that mutations in the human TBX5 gene underlie this disorder. TBX5 was cloned from the disease locus on human chromosome 12q24.1 and i