In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding.

Autor: Neil Bate, Christos G Savva, Peter C E Moody, Edward A Brown, Sian E Evans, Jonathan K Ball, John W R Schwabe, Julian E Sale, Nicholas P J Brindle

Publikováno v: PLoS Pathogens, Vol 18, Iss 7, p e1010733 (2022)

Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in develop

Externí odkaz: https://doaj.org/article/1c450b5c20754a42910056edeab3abf1

Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme

Autor: Hanna Kwon, Jaswir Basran, Cecilia M. Casadei, Alistair J. Fielding, Tobias E. Schrader, Andreas Ostermann, Juliette M. Devos, Pierre Aller, Matthew P. Blakeley, Peter C. E. Moody, Emma L. Raven

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)

The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to direct

Externí odkaz: https://doaj.org/article/ba0cf1877308498b991c38c8062c0431

Author Correction: A mechanism for CO regulation of ion channels

Autor: Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey, Emma Raven

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The originally published version of this article contained an error in the subheading ‘Heme is required for CO-dependent channel activation’, which was incorrectly given as ‘Hame is required for CO-dependent channel activation’. This has now

Externí odkaz: https://doaj.org/article/112dfef6f2674e25b9fc4f30441b3d46

Heme binding to human CLOCK affects interactions with the E-box

Autor: Umakhanth Venkatraman Girija, Emma Lloyd Raven, Alistair J. Fielding, Louise Fairall, Dimitri A. Svistunenko, Samuel L. Freeman, Charalambos P. Kyriacou, Gary Parkin, Nicola Portolano, Peter C. E. Moody, Hanna Kwon, Jaswir Basran, John W.R. Schwabe

Publikováno v: Freeman, S L, Kwon, H, Portolano, N, Parkin, G, Girija, U V, Basran, J, Fielding, A J, Fairall, L, Svistuneko, D A, Moody, P C E, Schwabe, J W R, Kyriacou, C P & Raven, E 2019, ' Heme binding to human CLOCK affects interactions with the E-box ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 40, pp. 19911-19916 . https://doi.org/10.1073/pnas.1905216116

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a24f39680f6f48b410fef70ef5d4af8
https://doi.org/10.1073/pnas.1905216116

Visualizing the protons in a metalloenzyme electron proton transfer pathway

Autor: Tobias E. Schrader, Reynier Suardíaz, Marc W. van der Kamp, Matthew P. Blakeley, Andreas Ostermann, Jaswir Basran, Hanna Kwon, Adrian J. Mulholland, Juliette M. Devos, Emma Lloyd Raven, Peter C. E. Moody

Publikováno v: Kwon, H, Basran, J, Devos, J M, Suardiaz Del Rio, R, Van Der Kamp, M W, Mulholland, A J, Schrader, T E, Ostermann, A, Blakeley, M P, Moody, P C E & Raven, E 2020, ' Visualizing the protons in a metalloenzyme electron proton transfer pathway ', Proceedings of the National Academy of Sciences of the United States of America . https://doi.org/10.1073/pnas.1918936117
Proceedings of the National Academy of Sciences of the United States of America 117(12), 6484-6490 (2020). doi:10.1073/pnas.1918936117
Proc Natl Acad Sci U S A

In redox metalloenzymes, the process of electron transfer often involves the concerted movement of a proton. These processes are referred to as proton-coupled electron transfer, and they underpin a wide variety of biological processes, including resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5d0c60b8dad118e90a1a4953bb4391
https://research-information.bris.ac.uk/en/publications/1fb08f30-b3f4-4c9c-8b9c-70b658dc8784