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of 5
pro vyhledávání: '"C E Higham"'
Autor:
C E Higham, A Olsson-Brown, P Carroll, T Cooksley, J Larkin, P Lorigan, D Morganstein, P J Trainer, Society for Endocrinology Clinical Committee
Publikováno v:
Endocrine Connections, Vol 7, Iss 7, Pp G1-G7 (2018)
Immunotherapy treatment with checkpoint inhibitors (CPI) (CTLA-4 and PD-1 inhibitors) significantly improves survival in a number of cancers. Treatment can be limited by immune-mediated adverse effects including endocrinopathies such as hypophysitis,
Externí odkaz:
https://doaj.org/article/83bfaf5bd2e1498ea37bb6376e5c4513
Autor:
C E, Higham, P J, Trainer
Publikováno v:
Experimental physiology. 93(11)
In 1990, a single amino acid substitution in the growth hormone (GH) gene at position 119 was found to transform the consequent protein from an agonist to an antagonist at the growth hormone receptor (GHR). Further amino acid substitutions plus prolo
Autor:
C. E. Higham, Stephen B. Wharton, Claire E. Lewis, Gareth H. Williams, John T. O'Brien, G. Forster, Raj N. Kalaria, K. Stoeber, Catherine Gelsthorpe, Carol Brayne, Pamela J. Shaw, Malee Fernando, Julie E. Simpson, Fiona E. Matthews, Robert Barber, Paul G. Ince
Publikováno v:
Neuropathology and applied neurobiology. 33(6)
White matter lesions (WML), a common feature in brain ageing, are classified as periventricular (PVL) or deep subcortical (DSCL), depending on their anatomical location. Microglial activation is implicated in a number of neurodegenerative diseases, b
Publikováno v:
British journal of pharmacology. 131(4)
The aim of this study was to determine whether antimalarial agents inhibit ATP-sensitive potassium (K(ATP)) channels and thereby contribute to the observed side-effects of these drugs. Mefloquine (10 - 100 microM), but not artenusate (100 microM), st
Autor:
C E, Higham, R L, Hull, L, Lawrie, K I, Shennan, J F, Morris, N P, Birch, K, Docherty, A, Clark
Publikováno v:
European journal of biochemistry. 267(16)
Islet amyloid polypeptide (IAPP), amylin, is the constituent peptide of pancreatic islet amyloid deposits which form in islets of Type 2 diabetic subjects. Human IAPP is synthesized as a 67-residue propeptide in islet beta-cells and colocalized with