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Radioimmunoassay Detects the Frequent Occurrence of Autoantibodies to the Mr 65,000 Isoform of Glutamic Acid Decarboxylase in Japanese Insulin-Dependent Diabetes

Autor: L. Li, Taro Maruyama, Åke Lernmark, Izumi Takei, Akira Kasuga, Takao Saruta, Alberto Falorni, Akira Shimada, Yukako Ozawa, C. E. Grubin, Tomohiro Kasatani

Publikováno v: Autoimmunity. 19:113-125

Glutamic acid decarboxylase antibodies (GAD65Ab) are common in new onset Caucasian insulin-dependent diabetic (IDDM) patients but it is unclear if this marker is also prevalent in patients of other ethnic backgrounds. We determined antibodies against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17edc4a18cd8988f2de5a0e7fc5760f7
https://doi.org/10.3109/08916939409009539

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Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase

Autor: W. A. Hagopian, B. Michelsen, A. E. Karlsen, F. Larsen, A. Moody, C. E. Grubin, R. Rowe, J. Petersen, R. McEvoy, A. Lernmark

Publikováno v: Diabetes. 42:631-636

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9257a7920a34267378a215075c75f600
https://doi.org/10.2337/diabetes.42.4.631

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Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies

Autor: A. E. Karlsen, W. A. Hagopian, J. S. Petersen, E. Boel, T. Dyrberg, C. E. Grubin, B. K. Michelsen, O. D. Madsen, A. Lernmark

Publikováno v: Diabetes. 41:1355-1359

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0169a00e0e3458bfe454d6160f483a95
https://doi.org/10.2337/diabetes.41.10.1355

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A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

Autor: C.I. Brannan, Stephen D. Lupton, Nancy A. Jenkins, C E Grubin, J M Wignall, B. Mosley, J.L. Slack, David Cosman, L.L. Brunton, Catherine J. McMahan

Publikováno v: The EMBO Journal. 10:2821-2832

cDNA clones corresponding to an Mr approximately 80,000 receptor (type I receptor) for interleukin-1 (IL-1) have been isolated previously by mammalian expression. Here, we report the use of an improved expression cloning method to isolate human and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db67a034b347d529c7b2f505da61c662
https://doi.org/10.1002/j.1460-2075.1991.tb07831.x

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HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus

Autor: Takao Saruta, Åke Lernmark, Yukio Ozawa, Taro Maruyama, Izumi Takei, A. Scheynius, K. Matsubara, C. E. Grubin, A. Kasuga, Alberto Falorni

Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89fa0532aa656a207ec0f6e44269cc6
http://hdl.handle.net/11391/1030467

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Cloning the interleukin 1 receptor from human T cells

Autor: C E Grubin, John E. Sims, Steven K. Dower, Carl J. March, R B Acres, J M Wignall, Catherine J. McMahan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 86(22)

cDNA clones of the interleukin 1 (IL-1) receptor expressed in a human T-cell clone have been isolated by using a murine IL-1 receptor cDNA as a probe. The human and mouse receptors show a high degree of sequence conservation. Both are integral membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1055462e86e5048f3bf6f8e0dcb61b
https://pubmed.ncbi.nlm.nih.gov/2530587

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