Zobrazeno 1 - 10
of 15
pro vyhledávání: '"C E Comment"'
Publikováno v:
Toxicological Sciences. 22:130-138
Mice with the severe combined immunodeficient (SCID) and triple-deficient (bg/nu/xid) mutations lack select populations of functional immune cells. Studies by several laboratories have demonstrated the ability to restore certain missing immune compon
Autor:
Dori R. Germolec, Christopher J. Portier, P L Pollock, Michael I. Luster, Kimber L. White, Gary J. Rosenthal, D. Gayla Pait, Emanuela Corsini, C E Comment, Y Kouchi, Albert E. Munson, Benny L. Blaylock, William A. Craig
Publikováno v:
Fundamental and Applied Toxicology. 21:71-82
Risk Assessment in Immonotoxicology. II. Relationships between Immune and Host Resistance Tests. Luster, M. I., Portier, C., Pait, D. G., Rosenthal, G. J., Germolec, D. R., Corsini, E., Blaylock, B. L., Pollock, P., Kouchi, Y., Craig, W., White, K. L
Publikováno v:
The Journal of Immunology. 150:5135-5143
T-2 toxin, a trichothecene mycotoxin, has previously been shown to alter immune functions and promote skin tumors. We demonstrate that topically applied T-2 toxin reduces the ear swelling response to oxazolone challenge in BALB/c mice. For this reduc
Autor:
C E Comment, Albert E. Munson, Gary J. Rosenthal, P L Pollock, D.G. Pait, Dori R. Germolec, Michael I. Luster, Kimber L. White, Christopher J. Portier
Publikováno v:
Toxicology Letters. :71-78
We have previously reported on the design and content of a screening battery using a “tier” approach for detecting potential immunosuppressive compounds in mice [1]. This battery was composed of various immune function, immunopathology and host r
Autor:
Gary J. Rosenthal, Michael I. Luster, J.J. Heindel, George C. Clark, B L Blaylock, C E Comment, S. D. Holladay, Dori R. Germolec
Publikováno v:
Chemosphere. 25:115-118
Immunotoxicity is a common occurrence in experimental animals following exposure to TCDD. In addition to thymic atrophy, immunotoxicity is characterized by suppression of antibody responses in adult mice and suppression of cell-mediated immunity foll
Publikováno v:
Toxicology and Applied Pharmacology. 112:207-213
We previously reported that thymic atrophy and reduced thymic cellularity associated with prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice are characterized by quantitative alerations in the number of thymocytes expressing CD4
Publikováno v:
The Journal of Immunology. 147:2116-2121
The mechanism of action of pentamidine isethionate, a diamidino compound used in the treatment of Pneumocystis carinii pneumonia, is unknown. We recently reported that this drug may inhibit the release of inflammatory mediators from alveolar macropha
Autor:
C E Comment, Dori R. Germolec, J. J. Heindell, P. Lindstrom, Michael I. Luster, B L Blaylock, S. D. Holladay
Publikováno v:
Teratology. 44:385-393
In utero exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was found to alter expression of murine thymocyte fetal cell-surface markers. Pregnant mice were treated (via gavage) with 0, 1.5, or 3.0 micrograms TCDD/kg
Autor:
Gary J. Rosenthal, Robert P. Stranahan, Michael I. Luster, Morrow B. Thompson, C E Comment, Patricia C. Blair, Kellogg Schwab, Dori R. Germolec
Publikováno v:
Fundamental and Applied Toxicology. 14:666-675
Interferon-alpha (IFN-alpha) is a naturally occurring cytokine that mediates numerous biological activities and has demonstrated therapeutic potential in a variety of malignancies. Encouraging activity against HIV-1 replication has also been observed
Autor:
Kenneth S. Korach, Michael I. Luster, Jerrold J. Heindel, Steven D. Holladay, William M. Fox, C E Comment, B L Blaylock
Publikováno v:
Cellular immunology. 152(1)
Estrogens have been reported to modulate immunologic responses at both physiologic and pharmacologic concentrations. Treatment of experimental animals with the synthetic estrogen, diethylstilbesterol (DES), markedly decreases thymic cellularity, mani