Zobrazeno 1 - 10
of 10
pro vyhledávání: '"C E, Whitehurst"'
Autor:
C E Whitehurst, T D Geppert
Publikováno v:
The Journal of Immunology. 156:1020-1029
TCR engagement stimulates the activation of the protein kinase Raf-1. Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149f445c7d4c5eb11ced01d1e38bdfb5
https://doi.org/10.4049/jimmunol.156.3.1020
https://doi.org/10.4049/jimmunol.156.3.1020
Publikováno v:
Journal of Clinical Investigation. 89:1839-1848
Previous studies have shown that the gold compounds, gold sodium thiomalate (GST) and auranofin (AUR), which are effective in the treatment of rheumatoid arthritis, inhibit functional activities of a variety of cells, but the biochemical basis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98554f5a86bd3c467fe266258417c50
https://doi.org/10.1172/jci115788
https://doi.org/10.1172/jci115788
Publikováno v:
The Journal of Immunology. 148:3230-3237
Extracellular signal-regulated kinases (ERK) 1 and 2 are growth factor- and cytokine-sensitive serine/threonine kinases that are known to phosphorylate microtubule-associated protein 2 and myelin basic protein. The current studies examined whether ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4b09462f9539df5139f94523bfdb88
https://doi.org/10.4049/jimmunol.148.10.3230
https://doi.org/10.4049/jimmunol.148.10.3230
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(1)
CD3 gamma, delta, epsilon, and zeta proteins together with the pre-TCR alpha-chain (pT alpha) and a rearranged TCR beta-chain assemble to form the pre-TCR that controls the double negative (DN) to double positive (DP) stages of thymopoiesis. The CD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a15b11ae76f2bbe8238dfd2bc6435dad
https://pubmed.ncbi.nlm.nih.gov/9886373
https://pubmed.ncbi.nlm.nih.gov/9886373
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(3)
Allelic exclusion is the process wherein lymphocytes express Ag receptors from only one of two possible alleles, and is effected through a feedback inhibition of further rearrangement of the second allele. The feedback signal is thought to cause chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eed1ec2b2161616112673135054cf222
https://pubmed.ncbi.nlm.nih.gov/9570542
https://pubmed.ncbi.nlm.nih.gov/9570542
Autor:
C E, Whitehurst, T D, Geppert
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(3)
TCR engagement stimulates the activation of the protein kinase Raf-1. Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1929436cd80a33e850cbabca6d8d5812
https://pubmed.ncbi.nlm.nih.gov/8557975
https://pubmed.ncbi.nlm.nih.gov/8557975
Publikováno v:
Molecular medicine (Cambridge, Mass.). 1(1)
BACKGROUND: Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most important and best studied of these cytokines is tumor necrosis factor (TNF). Detai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1dae0b9f4aff0e40b68b973aee291584
https://pubmed.ncbi.nlm.nih.gov/8790605
https://pubmed.ncbi.nlm.nih.gov/8790605
Publikováno v:
The Journal of rheumatology. 21(6)
Gold compounds have been employed as therapeutic agents for rheumatoid arthritis (RA) for many years, but the molecular mechanism of their action is unknown. Our studies were undertaken to compare the immunosuppressive activities of parenteral gold (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea32a2dbab803dfe267dde77444d8d89
https://pubmed.ncbi.nlm.nih.gov/7932408
https://pubmed.ncbi.nlm.nih.gov/7932408
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(10)
Extracellular signal-regulated kinases (ERK) 1 and 2 are growth factor- and cytokine-sensitive serine/threonine kinases that are known to phosphorylate microtubule-associated protein 2 and myelin basic protein. The current studies examined whether ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0a8166882e17ab0eb76cbb036d7ffd8
https://pubmed.ncbi.nlm.nih.gov/1533654
https://pubmed.ncbi.nlm.nih.gov/1533654
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 197(3)
A small population of cells with the ability to form rosettes with human erythrocytes was found in feline peripheral blood leukocytes (PBL) (10%) and bone marrow (9%), but not in purified granulocyte preparations, thymus, and lymph node tissues. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93e2ad4fecad405b833e58116f1c0d5
https://pubmed.ncbi.nlm.nih.gov/2068125
https://pubmed.ncbi.nlm.nih.gov/2068125