Zobrazeno 1 - 10
of 11
pro vyhledávání: '"C E, Tedford"'
Autor:
S L, Yates, J G, Phillips, R, Gregory, G P, Pawlowski, L, Fadnis, M A, Khan, S M, Ali, C E, Tedford
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
A new series of 1H-4-substituted imidazole compounds were synthesized and identified as potent and selective histamine (HA) H3 receptor ligands. These ligands establish that HA H3 antagonists exhibit stereoselective and conformational preferences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acc76fb1119187d2eae574556061b1c1
https://pubmed.ncbi.nlm.nih.gov/10215699
https://pubmed.ncbi.nlm.nih.gov/10215699
Autor:
C E, Tedford, J G, Phillips, R, Gregory, G P, Pawlowski, L, Fadnis, M A, Khan, S M, Ali, M K, Handley, S L, Yates
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
Previously, a novel series of 1H-4-substituted imidazole compounds were described as potent and selective histamine (HA) H3 receptor ligands (Yates et al., 1999). The present studies extend the structure-activity relationships for optimal HA H3 recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebef870114dde0cbcd94276ce78c7b64
https://pubmed.ncbi.nlm.nih.gov/10215700
https://pubmed.ncbi.nlm.nih.gov/10215700
Autor:
C E, Tedford, S L, Yates, G P, Pawlowski, J W, Nalwalk, L B, Hough, M A, Khan, J G, Phillips, G J, Durant, R C, Frederickson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
GT-2016, a non-thiourea-containing imidazole, has been developed as a histamine H3 antagonist. In vitro and in vivo studies in rats were conducted to characterize receptor selectivity and autoreceptor functionality for GT-2016. GT-2016 demonstrated h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::777045529743ae4834ede59cca29f7b2
https://pubmed.ncbi.nlm.nih.gov/7473144
https://pubmed.ncbi.nlm.nih.gov/7473144
Autor:
T R, Tephly, B, Coffman, P, Styczynski, G, Rios, D M, Charkowski, M, Vanrollins, R D, McQuade, C E, Tedford
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(5)
Dopamine D-1 receptor antagonists are currently under investigation for use as antipsychotic agents. Two potent and selective D-1 receptor antagonists, SCH 39166 and SCH 23390, have been studied extensively in various experimental animal models. SCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fa3288ed5a901dae09b48c73276534f
https://pubmed.ncbi.nlm.nih.gov/7835222
https://pubmed.ncbi.nlm.nih.gov/7835222
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(6)
SCH 23390 is a novel benzazepine that selectively blocks dopamine receptors of the D1 subtype. Glucuronidation of this selective D1 antagonist was studied in vitro using rat liver microsomes. Methods to separate SCH 23390 glucuronide from SCH 23390 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b21c3f318206f2c18a93398a836a8346
https://pubmed.ncbi.nlm.nih.gov/1687024
https://pubmed.ncbi.nlm.nih.gov/1687024
Publikováno v:
Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases ISBN: 9781468458497
Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases
Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f877f704e97806afb04cf6b2942660
https://doi.org/10.1007/978-1-4684-5847-3_68
https://doi.org/10.1007/978-1-4684-5847-3_68
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 247(2)
The in vitro effects of a tertiary amine, 4-methyl piperidine analog of hemicholinium-3 (A-4), were investigated on acetylcholine (ACh) metabolism in rat striatal slices. Rat striatal slices were incubated in the presence of 1.0 microM [3H]-choline i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abb7050eb6eb8ed101e34f4eef875742
https://pubmed.ncbi.nlm.nih.gov/3183948
https://pubmed.ncbi.nlm.nih.gov/3183948
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 247(2)
Previous studies have shown that quaternary and tertiary 4-methyl piperidine derivatives of hemicholinium-3 (A-5 and A-4, respectively) are potent inhibitors of choline uptake. The d-, l-, and mesostereoisomers of A-5 and A-4 were separated and the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd53fd3baee56d90c18026babc696ac5
https://pubmed.ncbi.nlm.nih.gov/3183960
https://pubmed.ncbi.nlm.nih.gov/3183960
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 227(2)
Methanol poisoning in monkeys and humans is characterized by the development of formic acidemia, metabolic acidosis and ocular toxicity. Formate, the metabolite associated with the toxicity of methanol, is oxidized to carbon dioxide by a tetrahydrofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85347080b69558db50757532eb0e1d9d
https://pubmed.ncbi.nlm.nih.gov/6631717
https://pubmed.ncbi.nlm.nih.gov/6631717
Publikováno v:
Drug design and delivery. 3(1)
Previous publications on the title compounds, 1 and 2 ('A-4' and 'A-5'), reported pharmacological data on what were probably mixtures of optical isomers of unknown composition. The compounds can exist as an enantiomeric pair as well as a diastereomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b834b6cb2b3cb98fca71548aaeac3ab7
https://pubmed.ncbi.nlm.nih.gov/3255324
https://pubmed.ncbi.nlm.nih.gov/3255324