Výsledky vyhledávání - "C E, Smithen"

Romazarit. A potential disease-modifying antirheumatic drug

Autor: D Bradshaw, C R Self, J C Wickens, D. P. Bloxham, Peter James Machin, C H Cashin, B P Tong, W E Barber, C E Smithen, John Mervyn Osbond

Publikováno v: Journal of Medicinal Chemistry. 34:772-777

The synthesis of a series of substituted heterocyclic alkoxypropionic acids is described. They were evaluated for antiinflammatory effects in two animal models of chronic inflammation; adjuvant arthritis and type II collagen arthritis in the rat. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dbaf20a951916425ef40322324f05e
https://doi.org/10.1021/jm00106a044

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Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo

Autor: Barry D. Michael, Andrew I. Minchinton, Juliana Denekamp, N H Terry, Michael R.L. Stratford, F.A. Stewart, C E Smithen

Publikováno v: British Journal of Cancer

The survival of epidermal cells in vivo has been used to assess potential radiosensitizers. Mouse skin was made acutely hypoxic for the irradiations, to give radioprotection by a factor of 2.7-3.0. Several concentrations of each drug were used to det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1670d3fc33341a2ae6dc6eebde167177
https://doi.org/10.1038/bjc.1982.40

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Akademický článek

Skeletal Editing of (Hetero)Arenes Using Carbenes.

Autor: Liu, Zhaohong¹ (AUTHOR), Sivaguru, Paramasivam¹ (AUTHOR), Ning, Yongquan¹ (AUTHOR), Wu, Yong¹ (AUTHOR), Bi, Xihe^1,2 (AUTHOR) bixh507@nenu.edu.cn

Publikováno v: Chemistry - A European Journal. 7/26/2023, Vol. 29 Issue 42, p1-18. 18p.

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Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles

Autor: J C, Asquith, M E, Watts, K, Patel, C E, Smithen, G E, Adams

Publikováno v: Radiation research. 60(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e2d17daddc30d471d235516fbaba02f
https://pubmed.ncbi.nlm.nih.gov/10881704

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The Chemistry of Nitroimidazole Hypoxic Cell Radiosensitizers

Autor: C. R. Hardy, C. E. Smithen

Publikováno v: Advanced Topics on Radiosensitizers of Hypoxic Cells ISBN: 9781475704013

It is now well recognised that the imidazole ring system is an important component of many different types of natural products having a wide range of biological activities, including those essential for life itself. For example, in the form of the am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dc1bbdcb2854ae11f132129ffaa2070
https://doi.org/10.1007/978-1-4757-0399-3_1

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Polyfunctional radiosensitizers. VII. Radiosensitization by conformationally-restricted isomers of a nitroxyl biradical in vitro

Autor: B C, Millar, T C, Jenkins, C E, Smithen, S, Jinks

Publikováno v: Radiation research. 101(1)

Bothtrans-N,N'-bis(2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl)-1, 2-diaminocyclopropane[Ro31-2269] and its cis isomer [Ro 31-2778] selectively sensitized hypoxic Chinese hamster cells, line V-79-753B, to radiation by decreasing both the D0 value and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08817f6aeb2a4e09f35445c97b80f1d7
https://pubmed.ncbi.nlm.nih.gov/3969438

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Radiosensitization of Serratia marcescens by nitropyridinium compounds

Autor: R F, Anderson, K B, Patel, C E, Smithen

Publikováno v: The British journal of cancer. Supplement. 3

The two nitropyridinium compounds tested sensitize hypoxic Serratia marcescens to irradiation up to the oxygen enhancement level by two components which can be separated as a function of compound concentration. Sensitization above the initial plateau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fb6465fdd0a6e759878318d063a9f65
https://pubmed.ncbi.nlm.nih.gov/354674

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Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers

Autor: G E, Adams, I R, Flockhart, C E, Smithen, I J, Stratford, P, Wardman, M E, Watts

Publikováno v: Radiation research. 67(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80c30c5e637f22279ae5f609ff3ae079
https://pubmed.ncbi.nlm.nih.gov/940937

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Polyfunctional radiosensitizers IV. The effect of contact time and temperature on sensitization of hypoxic Chinese hamster cells in vitro by bifunctional nitroxyl compounds

Autor: B C, Millar, E M, Fielden, C E, Smithen

Publikováno v: The British journal of cancer. Supplement. 3

Three biradical nitroxyl compounds have been shown to modify the slope and shoulder region of the hypoxic cell survival curve of V79 cells to different degrees. The amount of sensitization produced by these compounds is dependent on the cell-drug con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::576d0637f4546b4cc26e6e11a4e17305
https://pubmed.ncbi.nlm.nih.gov/277261

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