Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses

Autor: J G Giri, J Wells, S K Dower, C E McCall, R N Guzman, J Slack, T A Bird, K Shanebeck, K H Grabstein, J E Sims

Publikováno v: The Journal of Immunology. 153:5802-5809

Two types of cellular IL-1Rs have been characterized and cloned from both human and murine sources. The type II IL-1R has a very short cytoplasmic domain and does not seem to participate in IL-1 signaling. We demonstrate that type II IL-1Rs are relea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::152e718ee5a733425125233e6b832c4c
https://doi.org/10.4049/jimmunol.153.12.5802

PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages.

Autor: Kadier, Kailibinuer¹ (AUTHOR), Niu, Tian¹ (AUTHOR), Ding, Baoli¹ (AUTHOR), Chen, Boya¹ (AUTHOR), Qi, Xuxin¹ (AUTHOR), Chen, Danni¹ (AUTHOR), Cheng, Xirui¹ (AUTHOR), Fang, Yizheng¹ (AUTHOR), Zhou, Jiahao¹ (AUTHOR), Zhao, Wenyi^1,2 (AUTHOR), Liu, Zeqi¹ (AUTHOR), Yuan, Yi¹ (AUTHOR), Zhou, Zhan^1,2 (AUTHOR), Dong, Xiaowu^1,2,3,4,5 (AUTHOR), Yang, Bo^{1,2,3,4,5,6,7} (AUTHOR), He, Qiaojun^{1,2,3,4,5,6,8} (AUTHOR), Cao, Ji^1,2,3,4,5,6 (AUTHOR) caoji88@zju.edu.cn, Jiang, Li^1,2 (AUTHOR) jiangli49@zju.edu.cn, Zhu, Cheng‐Liang^1,2,3,4,5,8 (AUTHOR) chengliangzhu@zju.edu.cn

Publikováno v: Advanced Science. 9/25/2024, Vol. 11 Issue 36, p1-18. 18p.

Regulation of phospholipase D-induced hydrolysis of choline-containing phosphoglycerides by cyclic AMP in human neutrophils

Autor: D E Agwu, C E McCall, L C McPhail

Publikováno v: The Journal of Immunology. 146:3895-3903

In human neutrophils, the chemotactic tripeptide FMLP and the protein kinase C activator PMA stimulate the breakdown of 1-O-[3H]alkyl-2-acyl-sn-glycero-3-phosphocholine ([3H]EAPC) and the formation of 1-O-[3H]alkyl-2-acyl-phosphatidic acid ([3H]-EAPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a802a467db7b1ded5a25ef233bc49b2
https://doi.org/10.4049/jimmunol.146.11.3895

Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming

Autor: S A Bauldry, C E McCall, S L Cousart, D A Bass

Publikováno v: The Journal of Immunology. 146:1277-1285

The cytokine, TNF-alpha, interacts with human neutrophils (PMN) via specific membrane receptors and primes leukotriene B4 (LTB4) production in PMN for subsequent stimulation by calcium ionophores. We have further examined the effects of TNF-alpha on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbdc6c53f15d90f421f3143d139e91fa
https://doi.org/10.4049/jimmunol.146.4.1277

Propranolol, a phosphatidate phosphohydrolase inhibitor, also inhibits protein kinase C

Autor: S, Sozzani, D E, Agwu, C E, McCall, J T, O'Flaherty, J D, Schmitt, J D, Kent, L C, McPhail

Publikováno v: The Journal of biological chemistry. 267(28)

Propranolol, a beta-adrenergic receptor antagonist, also inhibits phosphatidate phosphohydrolase, the enzyme that converts phosphatidic acid into diacylglycerol. This latter effect has prompted recent use of propranolol in studies examining the impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a296aed5265eff44c78bc7ce69b535af
https://pubmed.ncbi.nlm.nih.gov/1328200