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of 105
pro vyhledávání: '"C Dykeman"'
Autor:
Eric C. Dykeman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Protein expression in vivo is predominately controlled via regulatory feedback mechanisms that adjust the level of mRNA transcription. However for positive sense single-stranded RNA viruses, protein expression is often controlled via seconda
Externí odkaz:
https://doaj.org/article/8eaffa2a2fa441348844020e44338560
Autor:
Eric C Dykeman
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010870 (2023)
The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overa
Externí odkaz:
https://doaj.org/article/bc9c807381714e7c9a7b87b2fc0926a3
Publikováno v:
Royal Society Open Science, Vol 8, Iss 8 (2021)
Within-host models of COVID-19 infection dynamics enable the merits of different forms of antiviral therapy to be assessed in individual patients. A stochastic agent-based model of COVID-19 intracellular dynamics is introduced here, that incorporates
Externí odkaz:
https://doaj.org/article/62898a3bd1fc425fb30f6ef185b9fae6
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009306 (2021)
The vast majority of viruses consist of a nucleic acid surrounded by a protective icosahedral protein shell called the capsid. During viral infection of a host cell, the timing and efficiency of the assembly process is important for ensuring the prod
Externí odkaz:
https://doaj.org/article/52807203e35a4339a203ffa68379a6ab
Autor:
Rebecca Chandler-Bostock, Carlos P Mata, Richard J Bingham, Eric C Dykeman, Bo Meng, Tobias J Tuthill, David J Rowlands, Neil A Ranson, Reidun Twarock, Peter G Stockley
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009146 (2020)
Picornaviruses are important viral pathogens, but despite extensive study, the assembly process of their infectious virions is still incompletely understood, preventing the development of anti-viral strategies targeting this essential part of the lif
Externí odkaz:
https://doaj.org/article/e4d31b1bf4ee435ab3bd30a7c44a740a
Autor:
Shabih Shakeel, Eric C. Dykeman, Simon J. White, Ari Ora, Joseph J.B. Cockburn, Sarah J. Butcher, Peter G. Stockley, Reidun Twarock
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specif
Externí odkaz:
https://doaj.org/article/1edc545ea86c44ca9bf0cec5084edbad
Akademický článek
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Autor:
Farzad Fatehi, Richard J. Bingham, Eric C. Dykeman, Nikesh Patel, Peter G. Stockley, Reidun Twarock
Publikováno v:
Viruses, Vol 13, Iss 1, p 11 (2020)
Hepatitis B virus (HBV) is a major focus of antiviral research worldwide. The International Coalition to Eliminate HBV, together with the World Health Organisation (WHO), have prioritised the search for a cure, with the goal of eliminating deaths fro
Externí odkaz:
https://doaj.org/article/40f3105a1c0a49cc88473ce634244fdc
Conservation of Genetically-Embedded Virus Assembly Instructions: A Novel Route to Antiviral Therapy
Autor:
Reidun Twarock, Peter G. Stockley, Richard J. Bingham, Eric C. Dykeman, Pierre-Philippe Dechant
Publikováno v:
Proceedings, Vol 50, Iss 1, p 87 (2020)
Many single-stranded RNA viruses, including major viral pathogens, present RNA-encoded virus assembly instructions (VAIs) within their genetic message that can be isolated from the genetic code and repurposed for the design of virus-like particles. T
Externí odkaz:
https://doaj.org/article/2a44ca5379834be9a0494b6eeba5df32
Publikováno v:
eLife, Vol 6 (2017)
Segmented RNA viruses are ubiquitous pathogens, which include influenza viruses and rotaviruses. A major challenge in understanding their assembly is the combinatorial problem of a non-random selection of a full genomic set of distinct RNAs. This pro
Externí odkaz:
https://doaj.org/article/67b7891992914ca8bbfe5bd850b16b6c