Zobrazeno 1 - 10
of 45
pro vyhledávání: '"C Denise Okafor"'
Autor:
Ericka D Surrett, Kirsten R Guckes, Shyan Cousins, Terry B Ruskoski, Andrew G Cecere, Denise A Ludvik, C Denise Okafor, Mark J Mandel, Tim I Miyashiro
Publikováno v:
eLife, Vol 12 (2023)
To colonize a host, bacteria depend on an ensemble of signaling systems to convert information about the various environments encountered within the host into specific cellular activities. How these signaling systems coordinate transitions between ce
Externí odkaz:
https://doaj.org/article/73fe213109674156aadfc19de684a1b7
Autor:
Sabab Hasan Khan, Sean M Braet, Stephen John Koehler, Elizabeth Elacqua, Ganesh Srinivasan Anand, C Denise Okafor
Publikováno v:
eLife, Vol 11 (2022)
Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with conformational changes induced upon ligand binding. Understanding how conformational populations of
Externí odkaz:
https://doaj.org/article/236457d256c9411bb678f601ffd29649
Autor:
Timothy James Russell, Erandi K De Silva, Valerie M Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C Niles, Marcelo Jacobs-Lorena, C Denise Okafor, Francisco-Javier Gamo, Manuel Llinás
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010887 (2022)
Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial dru
Externí odkaz:
https://doaj.org/article/32dbbe0804b44aea83886f60da9addc8
Autor:
Nathaniel R Braffman, Terry B Ruskoski, Katherine M Davis, Nathaniel R Glasser, Cassidy Johnson, C Denise Okafor, Amie K Boal, Emily P Balskus
Publikováno v:
eLife, Vol 11 (2022)
The cyanobacterial enzyme CylK assembles the cylindrocyclophane natural products by performing two unusual alkylation reactions, forming new carbon–carbon bonds between aromatic rings and secondary alkyl halide substrates. This transformation is un
Externí odkaz:
https://doaj.org/article/8cbb4b7901944cd39636ec62571bafd4
Autor:
Jasmine C. Moody, Hiroshi Qadota, April R. Reedy, C. Denise Okafor, Niveda Shanmugan, Yohei Matsunaga, Courtney J. Christian, Eric A. Ortlund, Guy M. Benian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesi
Externí odkaz:
https://doaj.org/article/97b17489d39b4b8787aa01fe4c4441f9
Publikováno v:
Journal of Chemical Information and Modeling. 63:571-582
Allosteric pathways in proteins describe networks comprising amino acid residues which may facilitate the propagation of signals between distant sites. Through inter-residue interactions, dynamic and conformational changes can be transmitted from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148abdc994e9bc66d40abb5ffae0d984
https://doi.org/10.1021/acs.jcim.2c01096
https://doi.org/10.1021/acs.jcim.2c01096
Autor:
Stephanie L. Collins, Jonathan G. Stine, Jordan E. Bisanz, C. Denise Okafor, Andrew D. Patterson
Publikováno v:
Nature Reviews Microbiology. 21:236-247
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e124717a3ac0a81774c5c770314f015
https://doi.org/10.1038/s41579-022-00805-x
https://doi.org/10.1038/s41579-022-00805-x
Autor:
Ericka D Surrett, Kirsten R Guckes, Shyan Cousins, Terry B Ruskoski, Andrew G Cecere, Denise A Ludvik, C Denise Okafor, Mark J Mandel, Tim I Miyashiro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f13e30a8c4626a852a7e65e3453a9c2
https://doi.org/10.7554/elife.78544.sa2
https://doi.org/10.7554/elife.78544.sa2
Publikováno v:
bioRxiv
Nuclear receptors (NRs) are transcription factors that regulate essential biological processes in response to cognate ligands. An important part of NR function involves ligand-induced conformational changes that recruit coregulator proteins to the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8502aeb3ad284ace195748230d6b6412
https://europepmc.org/articles/PMC9900875/
https://europepmc.org/articles/PMC9900875/