Zobrazeno 1 - 10 of 149 pro vyhledávání: '"C David Weaver"'
1
Akademický článek
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons
Autor: Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel, C David Weaver, Kyle Emmitte, Wayne Frankel, Matthew C Weston
Publikováno v: eLife, Vol 13 (2024)
More than 20 recurrent missense gain-of-function (GOF) mutations have been identified in the sodium-activated potassium (KNa) channel gene KCNT1 in patients with severe developmental and epileptic encephalopathies (DEEs), most of which are resistant
Externí odkaz: https://doaj.org/article/c400c6aeddf44a7fa69400b6b4b9e3a2
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2
Akademický článek
Screening for AMPA receptor auxiliary subunit specific modulators.
Autor: Caleigh M Azumaya, Emily L Days, Paige N Vinson, Shaun Stauffer, Gary Sulikowski, C David Weaver, Terunaga Nakagawa
Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174742 (2017)
AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic latera
Externí odkaz: https://doaj.org/article/3f126ee9f67c48b9b6797376f26e0db2
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3
Akademický článek
Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels.
Autor: Rene Raphemot, Matthew F Rouhier, Daniel R Swale, Emily Days, C David Weaver, Kimberly M Lovell, Leah C Konkel, Darren W Engers, Sean R Bollinger, Corey Hopkins, Peter M Piermarini, Jerod S Denton
Publikováno v: PLoS ONE, Vol 9, Iss 11, p e110772 (2014)
Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing the effectiveness of co
Externí odkaz: https://doaj.org/article/e02339d3e86b4ec08682a15b3ac994af
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4
Akademický článek
Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons
Autor: Francis J. Prael III, Kwangho Kim, Yu Du, Brittany D. Spitznagel, Gary A. Sulikowski, Eric Delpire, C. David Weaver
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, a
Externí odkaz: https://doaj.org/article/494279392eab412885fe7d235f350b87
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5
Akademický článek
GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior
Autor: Ezequiel Marron Fernandez de Velasco, Lei Zhang, Baovi N. Vo, Megan Tipps, Shannon Farris, Zhilian Xia, Allison Anderson, Nicholas Carlblom, C. David Weaver, Serena M. Dudek, Kevin Wickman
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K+ (GIRK) channels, thereby moderating the influence of excitatory input on neuronal excitability. While most neuronal GIRK channels are formed
Externí odkaz: https://doaj.org/article/71558560ec304bf5a09b60698ab9c399
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8
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function
Autor: Maximilian Lyon, Ping Li, Juan J. Ferreira, Roman M. Lazarenko, Sujay V. Kharade, Meghan Kramer, Samantha J. McClenahan, Emily Days, Joshua A. Bauer, Brittany D. Spitznagel, C. David Weaver, Aluet Borrego Alvarez, Lis C. Puga Molina, Pascale Lybaert, Saayli Khambekar, Alicia Liu, Craig W. Lindsley, Jerod Denton, Celia M. Santi
Publikováno v: Proceedings of the National Academy of Sciences. 120
To fertilize an oocyte, the membrane potential of both mouse and human sperm must hyperpolarize (become more negative inside). Determining the molecular mechanisms underlying this hyperpolarization is vital for developing new contraceptive methods an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ede63a72f24deecc4d9bbc9e46c1f884
https://doi.org/10.1073/pnas.2212338120
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9
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence
Autor: Derrick Cumberbatch, Tetsuya Mori, Jie Yang, Dehui Mi, Paige Vinson, C. David Weaver, Carl Hirschie Johnson
Publikováno v: Science Signaling. 15
The intrinsic fluorescence of samples confounds the use of fluorescence-based sensors. This is of particular concern in high-throughput screening (HTS) applications using large chemical libraries containing intrinsically fluorescent compounds. To ove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65de35f4a841eadbdb9349e26ba5bdbe
https://doi.org/10.1126/scisignal.abq7618
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10
A BRET Ca
Autor: Derrick, Cumberbatch, Tetsuya, Mori, Jie, Yang, Dehui, Mi, Paige, Vinson, C David, Weaver, Carl Hirschie, Johnson
Publikováno v: Science signaling. 15(747)
The intrinsic fluorescence of samples confounds the use of fluorescence-based sensors. This is of particular concern in high-throughput screening (HTS) applications using large chemical libraries containing intrinsically fluorescent compounds. To ove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e917d17f4299704a21fcb20ede5508b
https://pubmed.ncbi.nlm.nih.gov/35973028
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