Zobrazeno 1 - 10
of 410
pro vyhledávání: '"C David James"'
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176683 (2017)
PTEN is among the most commonly mutated tumor suppressor genes in human cancer. However, studying the role of PTEN in the pathogenesis of cancer has been limited, in part, by the paucity of human cell-based isogenic systems that faithfully model PTEN
Externí odkaz:
https://doaj.org/article/778f7902cce845868ef8d8ec1c4fb8cc
Autor:
Sarah E Wheeler, Ann Marie Egloff, Lin Wang, C David James, Peter S Hammerman, Jennifer R Grandis
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117781 (2015)
OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) accounts for more than 5% of all cancers worldwide. The mortality rate of HNSCC has remained unchanged (approximately 50%) over the last few decades. Ubiquitous overexpression of wild type EGFR
Externí odkaz:
https://doaj.org/article/482a411aa33045cdb6613db41bb46b4e
Autor:
Rajendra P. Pangeni, Zhou Zhang, Angel A. Alvarez, Xuechao Wan, Namratha Sastry, Songjian Lu, Taiping Shi, Tianzhi Huang, Charles X. Lei, C. David James, John A. Kessler, Cameron W. Brennan, Ichiro Nakano, Xinghua Lu, Bo Hu, Wei Zhang, Shi-Yuan Cheng
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 432-448 (2018)
Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined th
Externí odkaz:
https://doaj.org/article/9f203d1a69c64cac8045dc5a3fdc5f92
Autor:
Ella N. Perrault, Jack M. Shireman, Eunus S. Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan Dixit, C. David James, Dieter H Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason Miska, Atique U. Ahmed
Publikováno v:
Science Advances. 9
During therapy, adaptations driven by cellular plasticity are partly responsible for driving the inevitable recurrence of glioblastoma (GBM). To investigate plasticity-induced adaptation during standard-of-care chemotherapy temozolomide (TMZ), we per
Autor:
Leonidas C. Platanias, C. David James, Feng Yue, Aneta H. Baran, Amy B. Heimberger, Elspeth M. Beauchamp, Lukas D. Streich, Christopher Gonzalez, Sang Ho, Candice Mazewski, Jamie N. Guillen Magaña, Ricardo E. Perez, Frank Eckerdt, Mariafausta Fischietti
Glioblastoma (GBM) is an aggressive and incurable brain tumor in nearly all instances, whose disease progression is driven in part by the glioma stem cell (GSC) subpopulation. Here, we explored the effects of Schlafen family member 11 (SLFN11) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272b2dd522cfb16e2f766a234ff10a96
https://doi.org/10.1158/2767-9764.c.6550988
https://doi.org/10.1158/2767-9764.c.6550988
Autor:
Leonidas C. Platanias, C. David James, Feng Yue, Aneta H. Baran, Amy B. Heimberger, Elspeth M. Beauchamp, Lukas D. Streich, Christopher Gonzalez, Sang Ho, Candice Mazewski, Jamie N. Guillen Magaña, Ricardo E. Perez, Frank Eckerdt, Mariafausta Fischietti
Supplementary Table S3 lists proteins that were found to bind SLFN11 before or after irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a8cab3fbb6d36c863c3001ac099363
https://doi.org/10.1158/2767-9764.22545635.v1
https://doi.org/10.1158/2767-9764.22545635.v1
Autor:
Leonidas C. Platanias, C. David James, Feng Yue, Aneta H. Baran, Amy B. Heimberger, Elspeth M. Beauchamp, Lukas D. Streich, Christopher Gonzalez, Sang Ho, Candice Mazewski, Jamie N. Guillen Magaña, Ricardo E. Perez, Frank Eckerdt, Mariafausta Fischietti
Fig. S1: Expression of SLFN family members after SLFN11 knockout. Fig. S2: Reduced 3-D invasion after SLFN11 knockout. Fig. S3: Expression of stem/progenitor markers after SLFN11 add-back. Table S1: Key resources table.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a27220299841390494e24b7f91b2db
https://doi.org/10.1158/2767-9764.22545641
https://doi.org/10.1158/2767-9764.22545641
Autor:
Leonidas C. Platanias, C. David James, Ramana V. Davuluri, Craig Horbinski, Ichiro Nakano, Shi-Yuan Cheng, Stewart Goldman, Angel A. Alvarez, Jessica Clymer, Ahmet Dirim Arslan, Yingtao Bi, Hridi Hussain, Lisa P. Magnusson, Kristen Alley, Frank D. Eckerdt, Jonathan B. Bell
Supplementary materials and methods for ALDEFLUOR assay and CD44 staining and data showing that patient-derived GSCs are enriched for ALDH+ cells and express CD44.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a01ca791720334b4a42e4cfc7aca6
https://doi.org/10.1158/1541-7786.22514899
https://doi.org/10.1158/1541-7786.22514899
Autor:
Anders I. Persson, William A. Weiss, Kevan M. Shokat, C. David James, Mitchel S. Berger, Jean L. Nakamura, Daniel W. Sirkis, Yvan H. Chanthery, Dustin J. Maly, Nan Li
Figure S2. Expression of potential targets of VX680 in human GBM cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddf3541420f36394191db093577a2b7
https://doi.org/10.1158/1535-7163.22502434
https://doi.org/10.1158/1535-7163.22502434
Autor:
C. David James, Theodore Nicolaides, Nicholas Butowski, Jann N. Sarkaria, Francis J. Giles, Andrew P. Mazar, Alexander H. Stegh, Shi-Yuan Cheng, Jeffrey J. Raizer, Andrew T. Parsa, Dennis Brown, Wang Shen, Tsun-Wen Yao, Tomoko Ozawa, Yasuyuki Yoshida
Supplementary Figure 1: NT113 Chemical Structure; Supplementary Figure 2: A) Relative expression of endogenous wild-type EGFR in parental U87 cells (U87p) vs. U87 cells transduced with EGFRvIII retrovirus (U87vIII). B) Relative expression of EGFRwt,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbd5bea4202ddc0551d890169f635ab
https://doi.org/10.1158/1535-7163.22502070
https://doi.org/10.1158/1535-7163.22502070