Zobrazeno 1 - 10
of 668
pro vyhledávání: '"C David James"'
Autor:
Rajendra P. Pangeni, Zhou Zhang, Angel A. Alvarez, Xuechao Wan, Namratha Sastry, Songjian Lu, Taiping Shi, Tianzhi Huang, Charles X. Lei, C. David James, John A. Kessler, Cameron W. Brennan, Ichiro Nakano, Xinghua Lu, Bo Hu, Wei Zhang, Shi-Yuan Cheng
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 432-448 (2018)
Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined th
Externí odkaz:
https://doaj.org/article/9f203d1a69c64cac8045dc5a3fdc5f92
Autor:
Ella N. Perrault, Jack M. Shireman, Eunus S. Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan Dixit, C. David James, Dieter H Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason Miska, Atique U. Ahmed
Publikováno v:
Science Advances. 9
During therapy, adaptations driven by cellular plasticity are partly responsible for driving the inevitable recurrence of glioblastoma (GBM). To investigate plasticity-induced adaptation during standard-of-care chemotherapy temozolomide (TMZ), we per
Autor:
Andrey Ugolkov, Wenan Qiang, Gennadiy Bondarenko, Daniel Procissi, Irina Gaisina, C. David James, James Chandler, Alan Kozikowski, Hendra Gunosewoyo, Thomas O'Halloran, Jeffrey Raizer, Andrew P. Mazar
Publikováno v:
Translational Oncology, Vol 10, Iss 4, Pp 669-678 (2017)
Resistance to chemotherapy remains a major challenge in the treatment of human glioblastoma (GBM). Glycogen synthase kinase-3β (GSK-3β), a positive regulator of NF-κB–mediated survival and chemoresistance of cancer cells, has been identified as
Externí odkaz:
https://doaj.org/article/f432510ec6364bdcb9e59663f8b8df25
Autor:
Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1858-1873 (2017)
Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma (GBM). Our in silico and wet-bench analyses indicate that non-mu
Externí odkaz:
https://doaj.org/article/f4d292ac8f8346f8ab26ed8e258f99d4
Autor:
Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard, Amanda M. Saratsis
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-12 (2017)
Abstract Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterize
Externí odkaz:
https://doaj.org/article/5b0fa5b8d5af4d58a2000afafe4e9abf
Autor:
Jing Zhou, An-Chi Tien, John A. Alberta, Scott B. Ficarro, Amelie Griveau, Yu Sun, Janhavee S. Deshpande, Joseph D. Card, Meghan Morgan-Smith, Wojciech Michowski, Rintaro Hashizume, C. David James, Keith L. Ligon, William D. Snider, Peter Sicinski, Jarrod A. Marto, David H. Rowitch, Charles D. Stiles
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3167-3177 (2017)
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmenta
Externí odkaz:
https://doaj.org/article/7fb9e82920cf40d1898b5c51de91b9b8
Autor:
Leonidas C. Platanias, C. David James, Feng Yue, Aneta H. Baran, Amy B. Heimberger, Elspeth M. Beauchamp, Lukas D. Streich, Christopher Gonzalez, Sang Ho, Candice Mazewski, Jamie N. Guillen Magaña, Ricardo E. Perez, Frank Eckerdt, Mariafausta Fischietti
Glioblastoma (GBM) is an aggressive and incurable brain tumor in nearly all instances, whose disease progression is driven in part by the glioma stem cell (GSC) subpopulation. Here, we explored the effects of Schlafen family member 11 (SLFN11) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272b2dd522cfb16e2f766a234ff10a96
https://doi.org/10.1158/2767-9764.c.6550988
https://doi.org/10.1158/2767-9764.c.6550988
Autor:
Leonidas C. Platanias, C. David James, Feng Yue, Aneta H. Baran, Amy B. Heimberger, Elspeth M. Beauchamp, Lukas D. Streich, Christopher Gonzalez, Sang Ho, Candice Mazewski, Jamie N. Guillen Magaña, Ricardo E. Perez, Frank Eckerdt, Mariafausta Fischietti
Supplementary Table S3 lists proteins that were found to bind SLFN11 before or after irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a8cab3fbb6d36c863c3001ac099363
https://doi.org/10.1158/2767-9764.22545635.v1
https://doi.org/10.1158/2767-9764.22545635.v1
Autor:
Leonidas C. Platanias, C. David James, Feng Yue, Aneta H. Baran, Amy B. Heimberger, Elspeth M. Beauchamp, Lukas D. Streich, Christopher Gonzalez, Sang Ho, Candice Mazewski, Jamie N. Guillen Magaña, Ricardo E. Perez, Frank Eckerdt, Mariafausta Fischietti
Fig. S1: Expression of SLFN family members after SLFN11 knockout. Fig. S2: Reduced 3-D invasion after SLFN11 knockout. Fig. S3: Expression of stem/progenitor markers after SLFN11 add-back. Table S1: Key resources table.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a27220299841390494e24b7f91b2db
https://doi.org/10.1158/2767-9764.22545641
https://doi.org/10.1158/2767-9764.22545641
Autor:
Leonidas C. Platanias, C. David James, Ramana V. Davuluri, Craig Horbinski, Ichiro Nakano, Shi-Yuan Cheng, Stewart Goldman, Angel A. Alvarez, Jessica Clymer, Ahmet Dirim Arslan, Yingtao Bi, Hridi Hussain, Lisa P. Magnusson, Kristen Alley, Frank D. Eckerdt, Jonathan B. Bell
Supplementary materials and methods for ALDEFLUOR assay and CD44 staining and data showing that patient-derived GSCs are enriched for ALDH+ cells and express CD44.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a01ca791720334b4a42e4cfc7aca6
https://doi.org/10.1158/1541-7786.22514899
https://doi.org/10.1158/1541-7786.22514899