Zobrazeno 1 - 10
of 374
pro vyhledávání: '"C David Allis"'
Autor:
Changyu Zhu, Yadira M Soto-Feliciano, John P Morris, Chun-Hao Huang, Richard P Koche, Yu-jui Ho, Ana Banito, Chun-Wei Chen, Aditya Shroff, Sha Tian, Geulah Livshits, Chi-Chao Chen, Myles Fennell, Scott A Armstrong, C David Allis, Darjus F Tschaharganeh, Scott W Lowe
Publikováno v:
eLife, Vol 12 (2023)
Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemia family me
Externí odkaz:
https://doaj.org/article/00891c2adbc24612b3cca84dd953d236
Autor:
Benjamin A. Nacev, Yakshi Dabas, Matthew R. Paul, Christian Pacheco, Michelle Mitchener, Yekaterina Perez, Yan Fang, Alexey A. Soshnev, Douglas Barrows, Thomas Carroll, Nicholas D. Socci, Samantha C. St. Jean, Sagarika Tiwari, Michael J. Gruss, Sebastien Monette, William D. Tap, Benjamin A. Garcia, Tom Muir, C. David Allis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic alterations in epigenetic regulators. This includes missense mutations in histones, which, together with associated DNA, form nucleosome core particles. How
Externí odkaz:
https://doaj.org/article/a8ab4f3e792a49f58af3860467b6cc16
Autor:
Benjamin A. Nacev, Yakshi Dabas, Matthew R. Paul, Christian Pacheco, Michelle Mitchener, Yekaterina Perez, Yan Fang, Alexey A. Soshnev, Douglas Barrows, Thomas Carroll, Nicholas D. Socci, Samantha C. St. Jean, Sagarika Tiwari, Michael J. Gruss, Sebastien Monette, William D. Tap, Benjamin A. Garcia, Tom Muir, C. David Allis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f1c8467acfda4feead04f5a45957d930
Autor:
Altuna Akalin, Francine E Garrett-Bakelman, Matthias Kormaksson, Jennifer Busuttil, Lu Zhang, Irina Khrebtukova, Thomas A Milne, Yongsheng Huang, Debabrata Biswas, Jay L Hess, C David Allis, Robert G Roeder, Peter J M Valk, Bob Löwenberg, Ruud Delwel, Hugo F Fernandez, Elisabeth Paietta, Martin S Tallman, Gary P Schroth, Christopher E Mason, Ari Melnick, Maria E Figueroa
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002781 (2012)
We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands. Applying this meth
Externí odkaz:
https://doaj.org/article/cc7e491136c64fee8e206697389fba8c
Autor:
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Publikováno v:
Cancer Discovery. 13:146-169
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
ChIP-Seq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17caa0aa8fb1356b5a7ce1ae746170e7
https://doi.org/10.1158/2159-8290.22542055
https://doi.org/10.1158/2159-8290.22542055
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
Sequences of sgRNAs and primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcda721a657db3047fd126e2892aadd
https://doi.org/10.1158/2159-8290.22542061
https://doi.org/10.1158/2159-8290.22542061
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f9a27688c8427afa406f20015bed3
https://doi.org/10.1158/2159-8290.c.6549793
https://doi.org/10.1158/2159-8290.c.6549793
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
RNA-Seq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42753da56fe296de83bbedd0357e9a1f
https://doi.org/10.1158/2159-8290.22542052
https://doi.org/10.1158/2159-8290.22542052
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
CRISPR screen results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0028c2acb2959b0e069ce9a57ca288
https://doi.org/10.1158/2159-8290.22542058.v1
https://doi.org/10.1158/2159-8290.22542058.v1