Zobrazeno 1 - 10
of 149
pro vyhledávání: '"C David, Weaver"'
Autor:
Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel, C David Weaver, Kyle Emmitte, Wayne Frankel, Matthew C Weston
Publikováno v:
eLife, Vol 13 (2024)
More than 20 recurrent missense gain-of-function (GOF) mutations have been identified in the sodium-activated potassium (KNa) channel gene KCNT1 in patients with severe developmental and epileptic encephalopathies (DEEs), most of which are resistant
Externí odkaz:
https://doaj.org/article/c400c6aeddf44a7fa69400b6b4b9e3a2
Autor:
Alshaima’a M. Qunies, Brittany D. Spitznagel, Yu Du, Paul K. Peprah, Yasmeen K. Mohamed, C. David Weaver, Kyle A. Emmitte
Publikováno v:
Molecules, Vol 29, Iss 11, p 2437 (2024)
Gain-of-function mutations in the KCNT1 gene, which encodes the sodium-activated potassium channel known as SLACK, are associated with the rare but devastating developmental and epileptic encephalopathy known as epilepsy of infancy with migrating foc
Externí odkaz:
https://doaj.org/article/0f2c5566b05b4d4bb6e0881d09280aae
Autor:
Francis J. Prael III, Kwangho Kim, Yu Du, Brittany D. Spitznagel, Gary A. Sulikowski, Eric Delpire, C. David Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, a
Externí odkaz:
https://doaj.org/article/494279392eab412885fe7d235f350b87
Autor:
Katrin M. Krebs, Eva M. Pfeil, Katharina Simon, Manuel Grundmann, Felix Häberlein, Oscar M. Bautista-Aguilera, Michael Gütschow, C. David Weaver, Bernd K. Fleischmann, Evi Kostenis
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 14814-14823 (2018)
Externí odkaz:
https://doaj.org/article/cf66ec141f544b888b152e97640163db
Autor:
Ezequiel Marron Fernandez de Velasco, Lei Zhang, Baovi N. Vo, Megan Tipps, Shannon Farris, Zhilian Xia, Allison Anderson, Nicholas Carlblom, C. David Weaver, Serena M. Dudek, Kevin Wickman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K+ (GIRK) channels, thereby moderating the influence of excitatory input on neuronal excitability. While most neuronal GIRK channels are formed
Externí odkaz:
https://doaj.org/article/71558560ec304bf5a09b60698ab9c399
Autor:
Samantha J. McClenahan, Caitlin N. Kent, Sujay V. Kharade, Elena Isaeva, Jade C. Williams, Changho Han, Andrew Terker, Robert Gresham, Roman M. Lazarenko, Emily L. Days, Ian M. Romaine, Joshua A. Bauer, Olivier Boutaud, Gary A. Sulikowski, Raymond Harris, C. David Weaver, Alexander Staruschenko, Craig W. Lindsley, Jerod S. Denton
Publikováno v:
Mol Pharmacol
Heteromeric Kir4.1/Kir5.1 (KCNJ10/KCNJ16) inward rectifier potassium (Kir) channels play key roles in the brain and kidney, but pharmacological tools for probing their physiology and therapeutic potential have not been developed. Here, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fbdcbfcd068da9cf2cba3d0be7037f
https://doi.org/10.1124/molpharm.121.000464
https://doi.org/10.1124/molpharm.121.000464
Autor:
Christian L. Egly, Daniel J. Blackwell, Jeffrey Schmeckpeper, Brian P. Delisle, C. David Weaver, Björn C. Knollmann
Publikováno v:
Molecular Pharmacology. 101:236-245
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9e23903a36fe06814798849fd0ccad
https://doi.org/10.1124/molpharm.121.000421
https://doi.org/10.1124/molpharm.121.000421
Autor:
Maximilian Lyon, Ping Li, Juan J. Ferreira, Roman M. Lazarenko, Sujay V. Kharade, Meghan Kramer, Samantha J. McClenahan, Emily Days, Joshua A. Bauer, Brittany D. Spitznagel, C. David Weaver, Aluet Borrego Alvarez, Lis C. Puga Molina, Pascale Lybaert, Saayli Khambekar, Alicia Liu, Craig W. Lindsley, Jerod Denton, Celia M. Santi
Publikováno v:
Proceedings of the National Academy of Sciences. 120
To fertilize an oocyte, the membrane potential of both mouse and human sperm must hyperpolarize (become more negative inside). Determining the molecular mechanisms underlying this hyperpolarization is vital for developing new contraceptive methods an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede63a72f24deecc4d9bbc9e46c1f884
https://doi.org/10.1073/pnas.2212338120
https://doi.org/10.1073/pnas.2212338120
Autor:
Caleigh M Azumaya, Emily L Days, Paige N Vinson, Shaun Stauffer, Gary Sulikowski, C David Weaver, Terunaga Nakagawa
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174742 (2017)
AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic latera
Externí odkaz:
https://doaj.org/article/3f126ee9f67c48b9b6797376f26e0db2
Autor:
Derrick Cumberbatch, Tetsuya Mori, Jie Yang, Dehui Mi, Paige Vinson, C. David Weaver, Carl Hirschie Johnson
Publikováno v:
Science Signaling. 15
The intrinsic fluorescence of samples confounds the use of fluorescence-based sensors. This is of particular concern in high-throughput screening (HTS) applications using large chemical libraries containing intrinsically fluorescent compounds. To ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65de35f4a841eadbdb9349e26ba5bdbe
https://doi.org/10.1126/scisignal.abq7618
https://doi.org/10.1126/scisignal.abq7618