Zobrazeno 1 - 10
of 134
pro vyhledávání: '"C D Klaassen"'
Autor:
Xiang-Yang Wang, M Rahmani, D E Durrant, Masayuki Yamamoto, Huiping Zhou, Steven Grant, Sophie C. Cazanave, A J Sanyal, C D Klaassen
Publikováno v:
Cell Death & Differentiation. 21:1303-1312
Non-alcoholic steatohepatitis is characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA) and hepatocyte lipoapoptosis. This lipoapoptosis requires increased JNK phosphorylation and activation of the pro-apoptotic BH3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61477423610291e53b7628c5a20bbe1e
https://doi.org/10.1038/cdd.2014.49
https://doi.org/10.1038/cdd.2014.49
Autor:
C. D. Klaassen, C.-P. Siegers
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 108:1564-1570
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb3d6a5ba0f9813a947eaf1057ede6c
https://doi.org/10.1055/s-2008-1069787
https://doi.org/10.1055/s-2008-1069787
Autor:
C. D. Klaassen, M. G. Cherian, R. D. Palmiter, Michael Aschner, Ashley I. Bush, J. C. Erickson
Publikováno v:
Toxicology and Applied Pharmacology. 142:229-242
A symposium on the role of brain metallothioneins (MTs) in physiology and pathology was held at the 1996 Annual Society of Toxicology Meeting in Anaheim, California. The objectives of this symposium were to: (1) review the physiologic function of MTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dfd7b4b282aa2cba13bbb66a11f13d
https://doi.org/10.1006/taap.1996.8054
https://doi.org/10.1006/taap.1996.8054
Autor:
G L, Guo, C D, Klaassen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Rat oatp1 (Slc21a1) and oatp2 (Slc21a5) transport many structurally unrelated endogenous and exogenous compounds across the sinusoidal membrane of hepatocytes in a sodium-independent manner. There are several potential protein kinase A (PKA) and prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e65c66e4679e40f5bfdbbf68eb04e38d
https://pubmed.ncbi.nlm.nih.gov/11602666
https://pubmed.ncbi.nlm.nih.gov/11602666
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(11)
Identification and characterization of the pregnane X receptor (PXR) as a key regulator of cytochrome P450 3A (CYP3A) gene expression has led to an increased understanding of the molecular basis of many drug-drug interactions. Mice lacking PXR (PXR-K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a818e60332ff3ada75e433c5e32b4766
https://pubmed.ncbi.nlm.nih.gov/11602523
https://pubmed.ncbi.nlm.nih.gov/11602523
Publikováno v:
Toxicology. 163(2-3)
Metallothionein (MT) is a small-molecular weight, cysteine-rich protein that binds metals. The protective role of MT in Cd toxicity is well established but its ability to protect against toxicity of other metals remains unclear. In this study, wild-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca0c698235ce0867158cd9397b82dc4a
https://pubmed.ncbi.nlm.nih.gov/11516518
https://pubmed.ncbi.nlm.nih.gov/11516518
Autor:
D P, Hartley, C D, Klaassen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(5)
The importance of the cytochrome P450 (CYP) enzyme family in xenobiotic metabolism, as well as their differential expression and activity in response to a wide range of environmental chemicals and pharmaceuticals, is well documented. The objective of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dae654cf36a90c8f14a69d83e650249e
https://pubmed.ncbi.nlm.nih.gov/10772642
https://pubmed.ncbi.nlm.nih.gov/10772642
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
The ontogenic and hormonal regulation of a sulfotransferase, SULT1B1, was examined. Hepatic RNA was isolated from rats of various ages from 1 to 90 days. The mRNA for SULT1B1 is low for both sexes until a dramatic increase ( approximately 6-fold) occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af0933f6f56de1a51f469cf27b2cdc9a
https://pubmed.ncbi.nlm.nih.gov/10381794
https://pubmed.ncbi.nlm.nih.gov/10381794
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(1)
The purpose of this study was to examine whether intracellular metallothionein (MT) protects against acetaminophen hepatotoxicity. MT-I/II knockout (MT-null) and control mice were given acetaminophen (150-500 mg/kg i.p.), and liver injury was assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9da59d43cbb00c6bda9832edd16dce88
https://pubmed.ncbi.nlm.nih.gov/10087053
https://pubmed.ncbi.nlm.nih.gov/10087053