Zobrazeno 1 - 10
of 30
pro vyhledávání: '"C D, Schiller"'
Publikováno v:
ChemInform. 24
Syntheses of 6,7-dihydro-4H-indolones 6 and 10 by a selective Birch reduction of the benzene ring of the indole system are described. The antiestrogen zindoxifene and the 2-phenylindole 2 as well as 6 and 10 were tested for their relative binding aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::739494da446cb4713c960b88a527cc71
https://doi.org/10.1002/chin.199324162
https://doi.org/10.1002/chin.199324162
Publikováno v:
Urological Research. 19:7-13
Adrenal androgens are discussed as a reason for tumor progression after androgen ablation therapy. Because of the difference in the secretion of androgens by the adrenals of humans and rats, there is no reliable tumor model to study the role of adren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd48855e46548e05005190774e84293
https://doi.org/10.1007/bf00294013
https://doi.org/10.1007/bf00294013
Autor:
C. D. Schiller, Martin R. Schneider
Publikováno v:
Archiv der Pharmazie. 323:17-21
Among nonsteroidal antiandrogens, mostly compounds of the Flutamide-type are described. For the development of new compounds with affinity to androgen receptors and antiandrogenic activity five new hydroxy-substituted phenyltetralines were prepared a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ff565cfbcb02adef5272085894e00c
https://doi.org/10.1002/ardp.19903230106
https://doi.org/10.1002/ardp.19903230106
Publikováno v:
Archiv der Pharmazie. 323:417-420
Selective Birch-reduction of one of the phenolic rings of meso- or d,l-HES led to compounds 6a and 6b which exert a higher binding affinity to the androgen receptor as the respective parent HES. In vivo testing of 6a and 6b shows that 6a has the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179c05b95012fd6b6085bd4fbdd50cd0
https://doi.org/10.1002/ardp.19903230708
https://doi.org/10.1002/ardp.19903230708
Autor:
Anton Maucher, Helmut Schönenberger, Erwin von Angerer, Ronald Gust, Sabine Schertl, Thilo Spruss, Christine Batzl-Hartmann, Rolf W. Hartmann, Martin R. Schneider, C. D. Schiller
Publikováno v:
Journal of cancer research and clinical oncology. 133(3)
[Meso-1,2-bis(2,6-dihalo-3/4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL': 2,6-F(2),3-OH; meso-2-PtLL': 2,6-F(2),4-OH; meso-3-PtLL': 2,6-Cl(2),3-OH; meso-4-PtLL': 2,6-Cl(2),4-OH; L = OH(2), L' = OSO(3) or L,L' = Cl(2)) were desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a913265b2655912d39717bee15e5dc
https://pubmed.ncbi.nlm.nih.gov/17024493
https://pubmed.ncbi.nlm.nih.gov/17024493
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(1)
The pharmacokinetics of the tumor necrosis factor receptorimmunoglobulin fusion protein, lenercept, were assessed in rats, rabbits, dogs and cynomolgus monkeys. Pharmacokinetic parameters were extrapolated to humans by allometric scaling. Lenercept w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2df355fb5e94faa1ab2c4385dc99abe
https://pubmed.ncbi.nlm.nih.gov/9884305
https://pubmed.ncbi.nlm.nih.gov/9884305
Autor:
K J, Van Zee, L L, Moldawer, H S, Oldenburg, W A, Thompson, S A, Stackpole, W J, Montegut, M A, Rogy, C, Meschter, H, Gallati, C D, Schiller, W F, Richter, H, Loetscher, A, Ashkenazi, S M, Chamow, F, Wurm, S E, Calvano, S F, Lowry, W, Lesslauer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(6)
Fusion proteins of the human 55-kDa TNF receptor extracellular domain with hinge and C2/C3 constant domains of human IgG1 or IgG3 heavy chains were tested in a primate sepsis model. Twenty-four baboons received 4.6, or 0.2 mg/kg of TNFR5-G1,3, or pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11a5964859073f36f07674cb2b742749
https://pubmed.ncbi.nlm.nih.gov/8690912
https://pubmed.ncbi.nlm.nih.gov/8690912
Autor:
B, Valles, C D, Schiller, P, Coassolo, G, De Sousa, R, Wyss, D, Jaeck, A, Viger-Chougnet, R, Rahmani
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(10)
The arotinoid mofarotene is a novel potent anticancer compound. The metabolic profiles obtained from rat, dog, and human plasma showed a good correlation with the corresponding in vitro profiles observed with liver microsomes and hepatocytes. Intersp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6cf23d26a80e49159d67136acd5584e
https://pubmed.ncbi.nlm.nih.gov/8654192
https://pubmed.ncbi.nlm.nih.gov/8654192
Publikováno v:
Biochemical pharmacology. 46(9)
The O-deethylation of 7-ethoxy-4-trifluoromethylcoumarin (EFC) by liver microsomes has been assessed as a method for monitoring the activity of cytochrome P450. The principle advantage of this substrate is the formation of a fluorescent product 7-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::814d681a0c812deb93ef0c8f4fa9b5fb
https://pubmed.ncbi.nlm.nih.gov/8240414
https://pubmed.ncbi.nlm.nih.gov/8240414
Publikováno v:
Archiv der Pharmazie. 324(10)
Syntheses of 6,7-dihydro-4H-indolones 6 and 10 by a selective Birch reduction of the benzene ring of the indole system are described. The antiestrogen zindoxifene and the 2-phenylindole 2 as well as 6 and 10 were tested for their relative binding aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17702d0d818f72325ddc983f7a07aac3
https://pubmed.ncbi.nlm.nih.gov/1805709
https://pubmed.ncbi.nlm.nih.gov/1805709