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pro vyhledávání: '"C D, Heinen"'
Autor:
C D, Heinen, A E, Noffsinger, J, Belli, J, Straughen, J, Fischer, J, Groden, C M, Fenoglio-Preiser
Publikováno v:
Genes, chromosomescancer. 19(3)
An increased risk of colon cancer has been observed in individuals with long-standing ulcerative colitis (UC). In order to identify molecular genetic markers for the development of neoplasia in UC individuals, we isolated DNA from normal, regenerativ
Publikováno v:
Cancer research. 55(21)
Almost 20% of colon cancers are characterized by genomic instability at simple repeated sequences. This instability is the result of a deficient DNA mismatch repair system. Sporadic, as well as hereditary carcinomas of the proximal colon display this