Výsledky vyhledávání - "C D, Buckley"

Akademický článek

11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

Autor: C. G. Fenton, C. L. Doig, S. Fareed, A. Naylor, A. P. Morrell, O. Addison, C. Wehmeyer, C. D. Buckley, M. S. Cooper, G. G. Lavery, K. Raza, R. S. Hardy

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)

Abstract Background Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced osteoporosis (GIOP).

Externí odkaz: https://doaj.org/article/5c44e2a162a740648662dc940e7bc0af

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OP0075 FIBROBLAST/MACROPHAGE CROSSTALK VIA LACTATE: NEW THERAPEUTIC TARGET IN RHEUMATOID ARTHRITIS

Autor: V. Pucino, M. Nefla, V. Gauthier, S. A. Clayton, A. Filer, A. R. Clark, K. Raza, C. D. Buckley

Publikováno v: Annals of the Rheumatic Diseases. 81:51-52

BackgroundThe synovial membrane is the principal site of inflammation in rheumatoid arthritis (RA) and distinct subsets of fibroblasts and macrophages, with different effector functions, have been described within it1,2,3. Inflammation renders the RA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c967c2c354c95892a13a42c0ba799d25
https://doi.org/10.1136/annrheumdis-2022-eular.2323

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POS0481 DEFINING DISTINCT RESIDENT AND MIGRATORY FIBROBLAST POPULATIONS FROM SKIN BIOPSIES IN SYSTEMIC SCLEROSIS

Autor: K. Clark, A. Cole, X. Shiwen, V. Ong, C. D. Buckley, C. P. Denton

Publikováno v: Annals of the Rheumatic Diseases. 81:495.2-496

BackgroundRecent studies using single cell RNA sequencing have delineated distinct subpopulations of fibroblasts in skin and other organs. To improve understanding of functional differences between fibroblast subpopulations, we have developed a novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5de7eee0d505ab15576853ce32253a7
https://doi.org/10.1136/annrheumdis-2022-eular.2678

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Leucocyte trafficking (PP-028)

Autor: L. M. Butler, O. Pabst, J. Huehn, B. Wahl, K. Aalto, T. Amagai, K. Kunizawa, H. Kagechika, A. Blaschitz, D. M. Otte, W. Maier, T. Glant, M. H. Jang, T. Kobezda, T. Higuchi, N. Hayasaka, S. I. Hammerschmidt, N. Higashi, A. Angyal, J. Alferink, A. Yokota, U. Syrbe, O. Yoshie, P. Knolle, Y. Fu, L. Nikitina, M. Itoi, E. Fusaoka-Nishioka, E. Umemoto, G. E. Rainger, K. Mori, M. Nishimura, E. Kivi, C. Egelston, B. Schürmann, B. Szilagyi, M. Schimek, B. Nuernberg, S. Jin, M. Hashizume, Y. Nishimura, Y. Ohoka, K. Poppensieker, S. N. Syed, E. Kremmer, T. Kinashi, M. Koyama, J. Keuschnigg, K. Shimano, Noah J. Tubo, M. Mihara, S. Song, S. Jalkanen, H. Yagi, H. C. Jeffery, M. Zhu, M. Nakajima, L. Birnbaumer, M. Maksimow, H. Takeuchi, D. D. Le, P. Dresing, R. Kannagi, N. Sato, A. Waisman, M. Prinz, T. Henttinen, G. B. Nash, T. Salminen, T. Sugita, M. Masutani, James Campbell, M. F. Schroeter, T. Tanaka, K. Hieshima, Y. Nymalm, J. Hecht, T. Imai, K. Elima, M. Salmi, A. Mildner, Y. Higuchi, M. Ahrendt, Y. Wang, I. Förster, A. Zimmer, R. Yamaoka, T. Kubo, S. Scheu, C. Kato, A. Limmer, Y. Maeda, H. M. McGettrick, M. Iwata, A. Menning, C. D. Buckley, R. P. Piekorz, K. Chiba, J. E. Gessner, U. Bode, H. Ahammer, K. Tateishi, A. Filer, K. Mikecz, B. A. Ratsch, R. Förster, S. Ichimiya, A. K. Shirakawa, A. Fukunari, M. Pink, L. Klotz, M. Miyasaka, S. R. Ali, K. Sugahara, T. Katakai, R. E. Schmidt, G. Dohr, T. Nakayama, K. Wiege, P. Crocker, Y. Endo, N. Hogg, R. L. Wheat, D. J. Blackbourn, T. Irimura, Y. Uchiyama, A. Shigeta, A. Hamann, S. Floess, M. Sue, P. Sedlmayr, N. Tsukamoto, K. Katagiri, H. Elovaara, S. Yonekura, A. Kyusai

Publikováno v: International Immunology. 22:ii61-ii66

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af0a04b8f1b4e4bb64cf9854eff543cb
https://doi.org/10.1093/intimm/dxq115

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Cytokines and Inflammatory Mediators [30-39]: 30. The LPS Stimulated Production of Interleukin-10 is not Associated with -819C/T and -592C/A Promoter Polymorphisms in Healthy Indian Subjects

Publikováno v: Rheumatology. 49:i45-i48

Background: Interleukin-10 is a pivotal immunoregulatory cytokine with pleiotropic effects on the immune system. IL-10 promoter polymorphisms have been associated with disease susceptibility and the ability to secrete IL-10 in vitro. We suspected tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ccf9779b1fce81738ce7e8d8edf286
https://doi.org/10.1093/rheumatology/keq715

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Application of Airborne Passive Microwave Observations for Monitoring Inland Flooding Caused by Tropical Cyclones

Autor: Frank J. LaFontaine, C. D. Buckley, Robbie E. Hood

Publikováno v: Journal of Atmospheric and Oceanic Technology. 26:2051-2070

Inland flooding from tropical cyclones is a significant factor in storm-related deaths in the United States and other countries, with the majority of tropical cyclone fatalities recorded in the United States resulting from freshwater flooding. Inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::830b247e257fc57b8dd7f38e6ff1c5c6
https://doi.org/10.1175/2009jtecha1273.1

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Ultrasound-guided synovial biopsy: A safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

Autor: Frances Humby, Peter C. Taylor, Iain B. McInnes, Stephen Kelly, Costantino Pitzalis, V. Rocher, Michele Bombardieri, Rebecca Hands, M. Di Cicco, Andrew Filer, M-A D'Agostino, C D Buckley, N Ng

OBJECTIVE: To determine the tolerability, safety and yield of synovial tissue in an early arthritis cohort using a minimally invasive, ultrasound (US)-guided, synovial biopsy technique in small, medium and large joints. METHODS: 93 sequential biopsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007cff8f2810e2d1c15414c34c65f9a2
http://hdl.handle.net/10807/170221

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Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis

Autor: L, Yeo, H, Lom, M, Juarez, M, Snow, C D, Buckley, A, Filer, K, Raza, D, Scheel-Toellner

Publikováno v: Annals of the Rheumatic Diseases

Objectives The success of B cell targeting therapies has highlighted the importance of B cells in rheumatoid arthritis pathogenesis. We have previously shown that B cells in the RA synovium are capable of producing pro-inflammatory and bone-destructi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::999400e0429b959e7deeb743caf8af40
https://pubmed.ncbi.nlm.nih.gov/24431391

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Smoke exposure as a determinant of autoantibody titre in α₁-antitrypsin deficiency and COPD

Autor: A M, Wood, P, de Pablo, C D, Buckley, A, Ahmad, R A, Stockley

Publikováno v: The European respiratory journal. 37(1)

Liberation of elastin peptides from damaged lung may be a mechanism of autoimmune lung disease. Citrullination, and anti-citrullinated protein antibody formation occurs in smokers, but the role of smoking in autoantibody generation relevant to pulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::010f751cd89b60c4dcfd089eb235aac6
https://pubmed.ncbi.nlm.nih.gov/20525711

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Fibroblasts as novel therapeutic targets in chronic inflammation

Autor: S J, Flavell, T Z, Hou, S, Lax, A D, Filer, M, Salmon, C D, Buckley

Publikováno v: British journal of pharmacology. 153

A characteristic feature of many chronic inflammatory diseases is their persistence and predilection for certain sites. The molecular basis for such tissue tropism and failure of the inflammatory response to resolve has until relative recently remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cb48b58900ab22e77085ad2d82d6eb9
https://pubmed.ncbi.nlm.nih.gov/17965753

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