Zobrazeno 1 - 10
of 12 760
pro vyhledávání: '"C Costello"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background:Prostate cancer is a leading cause of cancer-related deaths among men, marked by heterogeneous clinical and molecular characteristics. The complexity of the molecular landscape necessitates tools for identifying multi-gene co-alteration pa
Externí odkaz:
https://doaj.org/article/3c48b08ff4464bb3acbf192fcd5deb5b
Autor:
Connor J. Hughes, Kaiah M. Fields, Etienne P. Danis, Jessica Y. Hsu, Deepika Neelakantan, Melanie Y. Vincent, Annika L. Gustafson, Michael J. Oliphant, Varsha Sreekanth, Vadym Zaberezhnyy, James C. Costello, Paul Jedlicka, Heide L. Ford
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early dissemination and poor outcome after distant spread. Here we demonstrat
Externí odkaz:
https://doaj.org/article/ee87edcfee7141c997bb753eb3383753
Autor:
Teemu D. Laajala, Varsha Sreekanth, Alex C. Soupir, Jordan H. Creed, Anni S. Halkola, Federico C. F. Calboli, Kalaimathy Singaravelu, Michael V. Orman, Christelle Colin-Leitzinger, Travis Gerke, Brooke L. Fridley, Svitlana Tyekucheva, James C. Costello
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Genomic and transcriptomic data have been generated across a wide range of prostate cancer (PCa) study cohorts. These data can be used to better characterize the molecular features associated with clinical outcomes and to test hypotheses acr
Externí odkaz:
https://doaj.org/article/74d7b11469474de8bb6ff94431c8476f
Autor:
Alexandra J. Lee, Dallas L. Mould, Jake Crawford, Dongbo Hu, Rani K. Powers, Georgia Doing, James C. Costello, Deborah A. Hogan, Casey S. Greene
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 5, Pp 912-927 (2022)
Genome-wide transcriptome profiling identifies genes that are prone to differential expression (DE) across contexts, as well as genes with changes specific to the experimental manipulation. Distinguishing genes that are specifically changed in a cont
Externí odkaz:
https://doaj.org/article/23d39b95a13b4a23a60211c9d4fe3a5c
Autor:
Meredith C. Costello, Emily L. Errante, Taylor Smartz, Wilson Z. Ray, Allan D. Levi, Stephen Shelby Burks
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionPeripheral nerve injuries are common neurologic injuries that are challenging to treat with current therapies. Electrical stimulation has been shown to accelerate reinnervation and enhance functional recovery. This study aims to review th
Externí odkaz:
https://doaj.org/article/e711e794582d424a9b89cb5f6388d6cc
Autor:
Samantha N. Thomas, Brian F. Niemeyer, Rocio J. Jimenez-Valdes, Alexander J. Kaiser, Joaquin M. Espinosa, Kelly D. Sullivan, Andrew Goodspeed, James C. Costello, Jonathan K. Alder, Rodrigo Cañas-Arranz, Adolfo García-Sastre, Kambez H. Benam
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107361- (2023)
Summary: Individuals with Down syndrome (DS) clinically manifest severe respiratory illnesses; however, there is a paucity of data on how DS influences homeostatic physiology of lung airway, and its reactive responses to pulmonary pathogens. We gener
Externí odkaz:
https://doaj.org/article/706040d3364d4b668e1e4718fba86159
Autor:
Meredith C. Costello, Emily L. Errante, Krisna Maddy, Joseph Yunga Tigre, Allan D. Levi, S. Shelby Burks
Publikováno v:
Interdisciplinary Neurosurgery, Vol 32, Iss , Pp 101743- (2023)
Background: Nerve injury following arthroscopic shoulder procedures is a rare complication. Most patients will have gradual resolution of symptoms. Operative management may be required in the setting of complete nerve injury. Purpose: We present a ca
Externí odkaz:
https://doaj.org/article/bec5f427ea0141eb989998c5973415eb
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Stress granules (SGs) are non-membrane bound cytoplasmic condensates that form in response to a variety of different stressors. Canonical SGs are thought to have a cytoprotective role, reallocating cellular resources during stress by activation of th
Externí odkaz:
https://doaj.org/article/077117bad52a4c2c9beebb6366739a79
Autor:
Mohammad El Garhy, Bernward Lauer, Björn Göbel, Lisa C. Costello-Boerrigter, Carsten Salomon, Harald Lapp, Marc-Alexander Ohlow
Publikováno v:
The Egyptian Heart Journal, Vol 73, Iss 1, Pp 1-7 (2021)
Abstract Background Percutaneous mitral valve (MV) clipping for mitral regurgitation (MR) revolutionized MV repair; however, valve anatomies and pathologies vary. Often multiple clips are required, and predicting this pre-procedurally would be useful
Externí odkaz:
https://doaj.org/article/29ede6d750b44d3a9cd3202e515e490c
Publikováno v:
Psychiatry International, Vol 2, Iss 3, Pp 265-276 (2021)
Transcranial Magnetic Stimulation (TMS) has a strong evidence base for the treatment of major depressive disorder (MDD), however, there is minimal research investigating the treatment of depression within the postpartum period. This systematic review
Externí odkaz:
https://doaj.org/article/756601c355074346b71616eea86d7794