Zobrazeno 1 - 2
of 2
pro vyhledávání: '"C C, Vinluan"'
Autor:
T D, Aicher, R C, Anderson, J, Gao, S S, Shetty, G M, Coppola, J L, Stanton, D C, Knorr, D M, Sperbeck, L J, Brand, C C, Vinluan, E L, Kaplan, C J, Dragland, H C, Tomaselli, A, Islam, R J, Lozito, X, Liu, W M, Maniara, W S, Fillers, D, DelGrande, R E, Walter, W R, Mann
Publikováno v:
Journal of medicinal chemistry. 43(2)
N'-methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC(50) = 180 microM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1772832e8ae976302ee3c02cf1e34f5
https://pubmed.ncbi.nlm.nih.gov/10649979
https://pubmed.ncbi.nlm.nih.gov/10649979
Autor:
J C, Jackson, C C, Vinluan, C J, Dragland, V, Sundararajan, B, Yan, J S, Gounarides, N R, Nirmala, S, Topiol, P, Ramage, J E, Blume, T D, Aicher, P A, Bell, W R, Mann
Publikováno v:
The Biochemical journal. 334
The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is diminished in animal models of diabetes. Studies with purified PDC components have suggested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0af0331558bdc163ccad75f9b83400da
https://pubmed.ncbi.nlm.nih.gov/9729480
https://pubmed.ncbi.nlm.nih.gov/9729480