Zobrazeno 1 - 10
of 13
pro vyhledávání: '"C C, Shone"'
Publikováno v:
Journal of applied microbiology. 107(4)
To develop a novel assay technique for the botulinum neurotoxin family (BoNTs) which is dependent on both the endopeptidase and receptor-binding activities of the BoNTs and which is insensitive to antigenic variation with the toxin family.An endopept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43dd723b93c258ebad920ae34ea80ae8
https://pubmed.ncbi.nlm.nih.gov/19426271
https://pubmed.ncbi.nlm.nih.gov/19426271
Autor:
Paul Dunnigan, K. A. Foster, A. Tauk, Matthew Wictome, C. C. Shone, Karen Jameson, Joy Gaze, S. Wright, Kirsti A. Newton, Sally Clarke
Publikováno v:
Rapid Detection Assays: For Food and Water ISBN: 9780854047796
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c653356b80ba584ddac84986f8fd34
https://doi.org/10.1039/9781847551818-00206
https://doi.org/10.1039/9781847551818-00206
Autor:
M, Wictome, K A, Newton, K, Jameson, P, Dunnigan, S, Clarke, J, Gaze, A, Tauk, K A, Foster, C C, Shone
Publikováno v:
Developments in biological standardization. 101
Currently the only accepted method for the detection of botulinum neurotoxin in contaminated samples is the mouse bio-assay. Although highly sensitive this test has a number of drawbacks: it is expensive to perform, lacks specificity and involves the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14902e42bdef0b4fc323641f6edd4d60
https://pubmed.ncbi.nlm.nih.gov/10566787
https://pubmed.ncbi.nlm.nih.gov/10566787
Autor:
C C, Shone, H S, Tranter
Publikováno v:
Current topics in microbiology and immunology. 195
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::428096498026d9891c582c23679c8188
https://pubmed.ncbi.nlm.nih.gov/8542752
https://pubmed.ncbi.nlm.nih.gov/8542752
Autor:
C. C. Shone, H. S. Tranter
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642851759
Various strains of Clostridium botulinum and C. tetani elaborate a family of eight structurally similar protein neurotoxins. The seven botulinum neurotoxins (types A-G) are distinguished on the basis of their reactions with specific antibodies and ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4046b2ef3353741f2b693e645110607a
https://doi.org/10.1007/978-3-642-85173-5_7
https://doi.org/10.1007/978-3-642-85173-5_7
Publikováno v:
The Journal of biological chemistry. 268(28)
Botulinum neurotoxin type A consists of a disulfide-linked light and heavy chain, with an intradisulfide present within the C-terminal half of the latter. The functional consequences of reducing these bonds and alkylating the thiols were investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74fc21124b3a24e0ab78faf61c990642
https://pubmed.ncbi.nlm.nih.gov/8104936
https://pubmed.ncbi.nlm.nih.gov/8104936
Publikováno v:
Scopus-Elsevier
Botulinum neurotoxin serotype F contains the zinc binding motif of zinc endopeptidases. Atomic adsorption analysis of highly purified toxin preparation revealed the presence of one atom of zinc per molecule of toxin, which could be removed with EDTA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3107e01834f4bd7d59f4fdf910c55164
https://pubmed.ncbi.nlm.nih.gov/8505288
https://pubmed.ncbi.nlm.nih.gov/8505288
Publikováno v:
Bioseparation. 3(5)
Bacterial protein toxins and their fragments have been isolated and purified for various reasons, including the development of efficient vaccines and for methods of identification of bacterial agents causing disease. This activity continues today but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b722300ee3200010795dbe89fb2e3ac8
https://pubmed.ncbi.nlm.nih.gov/1369426
https://pubmed.ncbi.nlm.nih.gov/1369426
Autor:
Ladislav Tauc, E. Habermann, Jonathan D. F. Wadsworth, B. Hogy, Bernard Poulain, C. C. Shone, S. Mochida, J. O. Dolly, U. Weller
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
The neuroparalytic activities of botulinum neurotoxin type A (BoNT A), tetanus toxin (TeTx), or homologous and heterologous combinations of their constituent polypeptides were examined at cholinergic and non-cholinergic synapses of Aplysia californic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ce4c9b01257a5503d1b8a78a326541
https://pubmed.ncbi.nlm.nih.gov/1674511
https://pubmed.ncbi.nlm.nih.gov/1674511