Výsledky vyhledávání - "C C, Huijbregts"

The balance between inhibition and substrate-type reactions of recombinant C1 inhibitor P5/P3 variants

Autor: E, Eldering, C C, Huijbregts, J H, Nuijens, C E, Hack

Publikováno v: Behring Institute Mitteilungen. (93)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44288d2ba601603d70a372d6af8a4158
https://pubmed.ncbi.nlm.nih.gov/8172559

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A novel sensitive assay for functional factor XII based on the generation of kallikrein-C1-inhibitor complexes in factor XII-deficient plasma by glass-bound factor XII

Autor: D M, Dors, J H, Nuijens, C C, Huijbregts, C E, Hack

Publikováno v: Thrombosis and haemostasis. 67(6)

We developed a very sensitive assay for functional factor XII. This assay is based on the property of glass-bound factor XII to activate prekallikrein (PK) into kallikrein in factor XII-deficient plasma, which is assessed by measuring the formation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a8c241551aec2d262d6a70aeb67ac01
https://pubmed.ncbi.nlm.nih.gov/1509403

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Characterization of recombinant C1 inhibitor P1 variants

Autor: E, Eldering, C C, Huijbregts, Y T, Lubbers, C, Longstaff, C E, Hack

Publikováno v: The Journal of biological chemistry. 267(10)

Twelve human C1 inhibitor P1 variants were constructed by site-directed mutagenesis of the codon for arginine 444 and were expressed in COS-1 cells to analyze the functional properties. The ability to bind to target proteases, as well as potential su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2b015b8305a7aa66598402a942e256d
https://pubmed.ncbi.nlm.nih.gov/1551909

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Quantification of functional and inactivated alpha 2-macroglobulin in sepsis

Autor: J J, Abbink, J H, Nuijens, A J, Eerenberg, C C, Huijbregts, R J, Strack van Schijndel, L G, Thijs, C E, Hack

Publikováno v: Thrombosis and haemostasis. 65(1)

Alpha 2-macroglobulin (alpha 2 M) in vitro inhibits numerous proteinases that are generated during inflammatory reactions and therefore, probably plays an important role in diseases such as sepsis. To monitor the state of alpha 2 M in sepsis, we deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5732cc00d5054dbf3337b706870874a1
https://pubmed.ncbi.nlm.nih.gov/1708920

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Quantification of plasma factor XIIa-Cl(-)-inhibitor and kallikrein-Cl(-)-inhibitor complexes in sepsis

Autor: J H, Nuijens, C C, Huijbregts, A J, Eerenberg-Belmer, J J, Abbink, R J, Strack van Schijndel, R J, Felt-Bersma, L G, Thijs, C E, Hack

Publikováno v: Blood. 72(6)

Considerable evidence indicates that activation of the contact system of intrinsic coagulation plays a role in the pathogenesis of septic shock. To monitor contact activation in patients with sepsis, we developed highly sensitive radioimmunoassays (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::766337d6f8e974a1318282f00318b29f
https://pubmed.ncbi.nlm.nih.gov/3264190

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Detection of activation of the contact system of coagulation in vitro and in vivo: quantitation of activated Hageman factor-C-1-inhibitor and kallikrein-C-1-inhibitor complexes by specific radioimmunoassays

Autor: J H, Nuijens, C C, Huijbregts, M, Cohen, G O, Navis, A, de Vries, A J, Eerenberg, J C, Bakker, C E, Hack

Publikováno v: Thrombosis and haemostasis. 58(2)

Radioimmunoassays (RIAs) for the detection of C-1-inhibitor (C-1-Inh) complexed to either kallikrein or activated Hageman factor (factor XIIa) are described. Kallikrein-C-1-Inh or factor XIIa-C-1-Inh complexes were bound to Sepharose to which monospe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e146a35d261f845ec2475f55464ee4f
https://pubmed.ncbi.nlm.nih.gov/2445044

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Inactivation of C-1 inhibitor by proteases: demonstration by a monoclonal antibody of a neodeterminant on inactivated, non-complexed C-1 inhibitor

Autor: J H, Nuijens, C C, Huijbregts, G M, van Mierlo, C E, Hack

Publikováno v: Immunology. 61(3)

Monoclonal antibodies were raised against kallikrein-C-1 inhibitor and factor XIIa-C-1 inhibitor complexes. One of the monoclonal antibodies (KII) appeared to react predominantly with C-1 inhibitor complexes in an ELISA. However, the apparent binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cda7f06944b3620aa648cbcbca903e57
https://pubmed.ncbi.nlm.nih.gov/2440799

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Activation of the contact system of coagulation by a monoclonal antibody directed against a neodeterminant in the heavy chain region of human coagulation factor XII (Hageman factor)

Autor: J H, Nuijens, C C, Huijbregts, A J, Eerenberg-Belmer, J C, Meijers, B N, Bouma, C E, Hack

Publikováno v: The Journal of biological chemistry. 264(22)

We studied the characteristics of two monoclonal antibodies (mAbs), F1 and F3, against human coagulation factor XII (Hageman factor). Experiments with trypsin-digested 125I-factor XII revealed that the epitope for mAb F1 is located in the NH2-termina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8630d6796fb80ac26f37c3db1a906ba2
https://pubmed.ncbi.nlm.nih.gov/2473984

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