Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins

Autor: Biruhalem Assefa, Jan Frystyk, Aikatarini Adamidou, Andreas Pfeiffer, Matthias Möhlig, C Bumke-Vogt, Andreas L. Birkenfeld, Zeinab Sarem, Volker Bähr, Stefanie Lieske, Martin O. Weickert, Ayman M. Mahmoud, Ayman M. Arafat, Joachim Spranger

Publikováno v: Sarem, Z, Bumke-Vogt, C, Mahmoud, A M, Assefa, B, Weickert, M O, Adamidou, A, Bähr, V, Frystyk, J, Möhlig, M, Spranger, J, Lieske, S, Birkenfeld, A L, Pfeiffer, A F H & Arafat, A M 2017, ' Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins ', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 9, pp. 3480-3490 . https://doi.org/10.1210/jc.2017-00558

Context: Depending on its lipolytic activity, glucagon plays a promising role in obesity treatment. Glucagon-induced growth hormone (GH) release can promote its effect on lipid metabolism, although the underlying mechanisms have not been well-defined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868c63a01d83f1a79e753e3edebf08ef
https://pubmed.ncbi.nlm.nih.gov/28911141

Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells

Autor: Andreas Pfeiffer, Inga Mewis, Andrea Borchert, Monika Schreiner, Valentina Guzmán-Pérez, C Bumke-Vogt

Publikováno v: PLOS ONE, 11(9):e0162397
PLoS ONE, Vol 11, Iss 9, p e0162397 (2016)
PLoS ONE

Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a hydrolysis product of benzyl glucosinolate—the benzyl isothiocyanate (BITC)—modulates the intracellular localization of the transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ca7803807b6ec4a29d7635dec2f5e9

Cell-type specific regulation of the human 11beta-hydroxysteroid dehydrogenase type 1 promoter

Autor: C Bumke-Vogt, J. Andres, Matthias Möhlig, Joachim Spranger, Martin O. Weickert, Knut Mai, Andreas Pfeiffer, Volker Bähr, Sven Diederich

Publikováno v: Archives of Physiology and Biochemistry. 113:110-115

The intracellular enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone into the more active metabolite cortisol. Overexpression of 11beta-HSD1 was associated with features of the metabolic syndrome such as obesity or imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f027383f15aa85208d20d595d3eb0b
https://doi.org/10.1080/13813450701531219

Expression of the progesterone receptor and progesterone- metabolising enzymes in the female and male human kidney

Autor: Marcus Quinkler, Wolfgang Oelkers, Volker Bähr, S. Diederich, I Anagnostopoulos, C Bumke-Vogt, S M Herrmann

Publikováno v: Journal of Endocrinology. 175:349-364

Due to high binding affinity of progesterone to the human mineralocorticoid receptor (hMR), progesterone competes with the natural ligand aldosterone. In order to analyse how homeostasis can be maintained by mineralocorticoid function of aldosterone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc1fa06815a391e863381369790b5f7
https://doi.org/10.1677/joe.0.1750349

Oral administration of nasturtium affects peptide YY secretion in male subjects

Autor: Monika Schreiner, Inga Mewis, Sascha Rohn, Olga Pivovarova, Margrit Kemper, Andreas Pfeiffer, C Bumke-Vogt, Stefanie Platz, Sonja Schiess

Publikováno v: Molecular Nutrition & Food Research. 61:1600886

Scope Nasturtium plants contain the glucosinolate glucotropaeolin and its corresponding breakdown product benzyl isothiocyanate (BITC), the latter being intensively studied with regard to cancer chemoprevention and anti-inflammatory properties. In ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039f7d10656788bc24a8139887cea067
https://doi.org/10.1002/mnfr.201600886