Zobrazeno 1 - 10
of 2 197
pro vyhledávání: '"C Blanchard"'
Publikováno v:
Continence, Vol 7, Iss , Pp 100749- (2023)
Externí odkaz:
https://doaj.org/article/cd1eb12ada314f8e8cdf98d0b6a5c0b9
Autor:
Kenneth C. Blanchard Jr
A reprint of Larry Arnhart's essay Darwinian Conservatism with comment and criticism from a variety of contributors.
Publikováno v:
Canada Communicable Disease Report, Vol 48, Iss 2-3, Pp 130-133 (2022)
La syphilis est une infection causée par les spirochètes de Treponema pallidum. Le diagnostic de cette maladie transmise sexuellement peut être manqué, en partie en raison de la nature indolore des ulcères génitaux au stade primaire. Au Canada,
Externí odkaz:
https://doaj.org/article/f4e38db57759475eacd709e116035acc
Publikováno v:
Canada Communicable Disease Report, Vol 48, Iss 2-3, Pp 115-118 (2022)
Syphilis is an infection caused by Treponema pallidum spirochetes. The diagnosis of this sexually transmitted disease may be missed, partly due to the painless nature of genital ulcers in its primary stage. Women in Canada are screened for syphilis i
Externí odkaz:
https://doaj.org/article/56c57ed2c6784b89be4eb2bc88bff5f6
Autor:
Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in
Externí odkaz:
https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176
Autor:
Manuel F Juette, Jordan D Carelli, Emily J Rundlet, Alan Brown, Sichen Shao, Angelica Ferguson, Michael R Wasserman, Mikael Holm, Jack Taunton, Scott C Blanchard
Publikováno v:
eLife, Vol 11 (2022)
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eE
Externí odkaz:
https://doaj.org/article/8f80b5c7131340bf8719fcfe6bafffa4
Autor:
Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conforma
Externí odkaz:
https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1
Autor:
Rory Henderson, Maolin Lu, Ye Zhou, Zekun Mu, Robert Parks, Qifeng Han, Allen L. Hsu, Elizabeth Carter, Scott C. Blanchard, R J Edwards, Kevin Wiehe, Kevin O. Saunders, Mario J. Borgnia, Alberto Bartesaghi, Walther Mothes, Barton F. Haynes, Priyamvada Acharya, S. Munir Alam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, using cryo-EM and smFRET, Henderson et al. show how tryptophan 571 in the HIV-1 Env acts as a conformational switch during receptor-mediated viral entry and design HIV-1 Env proteins that cannot undergo conformational changes. This has importan
Externí odkaz:
https://doaj.org/article/66b0bc924f5e41b8ab9751e365c7c967
Autor:
Varsha Prakash, Brittany B. Carson, Jennifer M. Feenstra, Randall A. Dass, Petra Sekyrova, Ayuko Hoshino, Julian Petersen, Yuan Guo, Matthew M. Parks, Chad M. Kurylo, Jake E. Batchelder, Kristian Haller, Ayako Hashimoto, Helene Rundqivst, John S. Condeelis, C. David Allis, Denis Drygin, M. Angela Nieto, Michael Andäng, Piergiorgio Percipalle, Jonas Bergh, Igor Adameyko, Ann-Kristin Östlund Farrants, Johan Hartman, David Lyden, Kristian Pietras, Scott C. Blanchard, C. Theresa Vincent
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Ribosomal DNA transcription is essential for cell growth and division. Here, the authors show that EMT is accompanied by Snail binding to rDNA operons and Rictor association with nucleoli to fuel an induction of ribosome biogenesis during G1/S cell c
Externí odkaz:
https://doaj.org/article/d55a3dcbab384f5da902c83d1a827b47
Autor:
Mikael Holm, S. Kundhavai Natchiar, Emily J. Rundlet, Alexander G. Myasnikov, Zoe L. Watson, Roger B. Altman, Hao-Yuan Wang, Jack Taunton, Scott C. Blanchard
Publikováno v:
Nature. 617:200-207
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems1. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd353b00676a97d2a2634ea6967f4a06
https://doi.org/10.1038/s41586-023-05908-w
https://doi.org/10.1038/s41586-023-05908-w