Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Autor: Svenja Sydor, Paul Manka, Jan Best, Sami Jafoui, Jan-Peter Sowa, Miguel Eugenio Zoubek, Virginia Hernandez-Gea, Francisco Javier Cubero, Julia Kälsch, Diana Vetter, Maria Isabel Fiel, Yujin Hoshida, C. Billie Bian, Leonard J. Nelson, Han Moshage, Klaas Nico Faber, Andreas Paul, Hideo A. Baba, Guido Gerken, Scott L. Friedman, Ali Canbay, Lars P. Bechmann

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular

Externí odkaz: https://doaj.org/article/2286249dec7344db8e423965de3b8b26

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Autor: Maria Isabel Fiel, Scott L. Friedman, Klaas Nico Faber, Virginia Hernández-Gea, Andreas Paul, Hideo A. Baba, Ali Canbay, Yujin Hoshida, Miguel Eugenio Zoubek, Julia Kälsch, Sami Jafoui, Francisco Javier Cubero, Paul Manka, Diana Vetter, Han Moshage, C Billie Bian, Lars P. Bechmann, Leonard J Nelson, Jan-Peter Sowa, Guido Gerken, Jan Best, Svenja Sydor

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports, 7(1):8119. Nature Publishing Group
Sydor, S, Manka, P, Best, J, Jafoui, S, Sowa, J-P, Zoubek, M E, Hernandez-Gea, V, Cubero, F J, Kälsch, J, Vetter, D, Fiel, M I, Hoshida, Y, Bian, C B, Nelson, L J, Moshage, H, Faber, K N, Paul, A, Baba, H A, Gerken, G, Friedman, S L, Canbay, A & Bechmann, L P 2017, ' Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury ', Scientific Reports, vol. 7, no. 1, pp. 8119 . https://doi.org/10.1038/s41598-017-08680-w

Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a44e88ba71ab8afa798e60c2a84a248
https://doaj.org/article/2286249dec7344db8e423965de3b8b26

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

Autor: Shigeki Nakagawa, Yujin Hoshida, Daniela Sia, Pedro Molina-Sánchez, Veronica Miguela, Amaia Lujambio, Josep M. Llovet, Victoria Tovar, Mark P. Roberto, Marina Ruiz de Galarreta, Christie B. Nguyen, Julien Bollard, C Billie Bian, Anu Venkatesh

Publikováno v: Gut
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Objective Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. Palbociclib, a well-tolerated and selective CDK4/6 inhibitor, has shown promising results in the treatment of retinoblastoma (RB1)-positive breas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ea5ca6dcf99070fea9bd1dc0f99e03
https://doi.org/10.1136/gutjnl-2016-312268

Cell type-specific pharmacological kinase inhibition for cancer chemoprevention

Autor: Klaas Poelstra, Marina Ruiz de Galarreta, Hadassa Hirschfield, Manjeet Deshmukh, Amaia Lujambio, Bryan C. Fuchs, Yujin Hoshida, Anna P. Koh, C Billie Bian, Noor B. Ahmad, Shigeki Nakagawa, Mohamed El-Abtah, Adam Vincek, Naoto Fujiwara, Roberto Sanchez, Anu Venkatesh, Jai Prakash, Takaaki Higashi, Hiroki Hoshida, Atsushi Ono, Nicolas Goossens

Publikováno v: Nanomedicine-Nanotechnology biology and medicine, 14(2), 317-325. ELSEVIER SCIENCE BV
Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine : nanotechnology, biology and medicine, 14(2), 317-325. Elsevier

Safety is prerequisite for preventive medicine, but non-toxic agents are generally ineffective as clinical chemoprevention. Here we propose a strategy overcoming this challenge by delivering molecular-targeted agent specifically to the effector cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c8fca197a4fb8622f21346e315c40c
https://research.rug.nl/en/publications/435d22fa-f1da-455f-bed7-3485b02f728b

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Autor: Mirjam B. Zeisel, Thomas F. Baumert, Simonetta Bandiera, C Billie Bian, Yujin Hoshida

Publikováno v: Current Opinion in Virology
Current Opinion in Virology, Elsevier, 2016, 20, pp.99-105. ⟨10.1016/j.coviro.2016.09.010⟩

Hepatitis C virus (HCV) infection is one of the major causes of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. While the knowledge about the molecular virology of HCV infection has markedly advanced, the molecular mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6ca2992c9d5cbf6528a890df2a82d3
https://linkinghub.elsevier.com/retrieve/pii/S1879625716301420