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Quantitative in vitro to in vivo Extrapolation (IVIVE) of Genotoxicity Data Provides Protective Estimates of in vivo Dose

Autor: Marc A. Beal, Marc Audebert, Tara Barton‐Maclaren, Hannah Battaion, Jeffrey C. Bemis, Xuefei Cao, Connie Chen, Stephen D. Dertinger, Roland Froetschl, Xiaoqing Guo, George Johnson, Giel Hendriks, Laure Khoury, Alexandra S. Long, Stefan Pfuhler, Raja S. Settivari, Shamika Wickramasuriya, Paul White

Publikováno v: Environmental and molecular mutagenesis, Early View

Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, aneugenicity) have been limited to dichotomous hazard classification, while other tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a6d59ccfacfcd3ddb681a0a6174ca8
https://pubmed.ncbi.nlm.nih.gov/36495195

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A cross-sectional clinical study in women to investigate possible genotoxicity and hematological abnormalities related to the use of black cohosh botanical dietary supplements

Autor: Stephanie L. Smith‐Roe, Stavros Garantziotis, Rebecca L. Church, Jeffrey C. Bemis, Dorothea K. Torous, Kim G. Shepard, Cheryl A. Hobbs, Suramya Waidyanatha, Esra Mutlu, Keith R. Shockley, Grace E. Kissling, Sandra J. McBride, Guanhua Xie, Tim Cristy, Jessica Pierfelice, Kristine L. Witt

Publikováno v: Environ Mol Mutagen

Black cohosh (BC; Actaea racemosa L.), a top-selling botanical dietary supplement, is marketed to women primarily to ameliorate a variety of gynecological symptoms. Due to widespread usage, limited safety information, and sporadic reports of hepatoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8568690d0ac87ececd0accb59d33cb
https://europepmc.org/articles/PMC10018809/

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Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity

Autor: Steven M. Bryce, Stephen D. Dertinger, Jeffrey C. Bemis

Publikováno v: Mutagenesis

The desire for in vitro genotoxicity assays to provide higher information content, especially regarding chemicals’ predominant genotoxic mode of action, has led to the development of a novel multiplexed assay available under the trade name MultiFlo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19e3b9eae7e1fc866b47b48792ff84d
https://doi.org/10.1093/mutage/geab014

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Human blood PIG‐A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra‐ and inter‐subject variation

Autor: Dorothea K. Torous, Lawrence J. Saubermann, Yuhchyau Chen, Svetlana L. Avlasevich, David P. Lovell, Stephen D. Dertinger, Vernon E. Walker, James T. MacGregor, Mona Khattab, Jeffrey C. Bemis, Ayesha Baig

Publikováno v: Environ Mol Mutagen

We previously described flow cytometry-based methods for scoring the incidence of micronucleated reticulocytes (MN-RET) and PIG-A mutant phenotype reticulocytes (MUT RET) in rodent and human blood samples. The current report describes important metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53bbdb1730702474576b03c972132a5
https://doi.org/10.1002/em.22393

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3Rs‐friendly approach to exogenous metabolic activation that supports high‐throughput genetic toxicology testing

Autor: Aiyana Cyr, Shuchang Tian, Steven M. Bryce, Jeffrey C. Bemis, Karen Zeise, Stephen D. Dertinger, Nikki E. Hall

Publikováno v: Environmental and Molecular Mutagenesis. 61:408-432

MultiFlow® DNA Damage-p53, γH2AX, Phospho-Histone H3 is a miniaturized, flow cytometry-based assay that provides genotoxic mode of action information by distinguishing clastogens, aneugens, and nongenotoxicants. Work to date has focused on the p53-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233bcb2245953a2611adc81b78c74436
https://doi.org/10.1002/em.22361

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Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds

Autor: Jeffrey C. Bemis, George E. Johnson, Derek T. Bernacki, Stephen D. Dertinger, Ryan P Wheeldon, Steven M. Bryce

Publikováno v: Environmental and Molecular Mutagenesis. 61:396-407

Genetic toxicology data have traditionally been utilized for hazard identification to provide a binary call for a compound's risk. Recent advances in the scientific field, especially with the development of high-throughput methods to quantify DNA dam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ce94d592675bec87520529ea04192f
https://doi.org/10.1002/em.22360

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In vitro Human Cell-Based Aneugen Molecular Mechanism Assay

Autor: Nikki E. Hall, Kyle Tichenor, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger

Publikováno v: Environ Mol Mutagen

This laboratory previously described an in vitro human cell-based assay and data analysis scheme that discriminates common molecular targets responsible for chemical-induced in vitro aneugenicity: tubulin destabilization, tubulin stabilization, and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945b638ceb6a65b4066a37b27897995
https://europepmc.org/articles/PMC9106857/

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