Zobrazeno 1 - 10 of 1 926 pro vyhledávání: '"C Bedi"'
1
Akademický článek
Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation
Autor: Matthew C. Hill, Bridget Simonson, Carolina Roselli, Ling Xiao, Caroline N. Herndon, Mark Chaffin, Helene Mantineo, Ondine Atwa, Harshit Bhasin, Yasmine Guedira, Kenneth C. Bedi, Kenneth B. Margulies, Carla A. Klattenhoff, Nathan R. Tucker, Patrick T. Ellinor
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia in humans, yet the molecular basis of AF remains incompletely understood. To determine the cell type-specific transcriptional changes underlying AF, we perform single-nucleus R
Externí odkaz: https://doaj.org/article/7b099e9da671463c89517f5597be9a33
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2
Akademický článek
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
Autor: Bridget Simonson, Mark Chaffin, Matthew C. Hill, Ondine Atwa, Yasmine Guedira, Harshit Bhasin, Amelia W. Hall, Sikander Hayat, Simon Baumgart, Kenneth C. Bedi, Jr., Kenneth B. Margulies, Carla A. Klattenhoff, Patrick T. Ellinor
Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112086- (2023)
Summary: Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the cellular and molecular signature of this disease is largely unclear. Using single-nucleus RNA sequencing (snRNA-seq) and integrated computational analyses
Externí odkaz: https://doaj.org/article/20970c7a3b5845f094b6b93928416d12
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3
Akademický článek
Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species
Autor: Mary T. Doan, Michael D. Neinast, Erika L. Varner, Kenneth C. Bedi, Jr., David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P. Singh, Cholsoon Jang, J. Eduardo Rame, Donita C. Brady, Jordan L. Meier, Kenneth B. Marguiles, Zoltan Arany, Nathaniel W. Snyder
Publikováno v: Journal of Lipid Research, Vol 63, Iss 6, Pp 100224- (2022)
Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not been shown to extensively occur. Mamm
Externí odkaz: https://doaj.org/article/37582cdc3e554e4a95aee9b775a2c9c9
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4
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction
Autor: Virginia S. Hahn, Christopher Petucci, Min-Soo Kim, Kenneth C. Bedi, Hanghang Wang, Sumita Mishra, Navid Koleini, Edwin J. Yoo, Kenneth B. Margulies, Zoltan Arany, Daniel P. Kelly, David A. Kass, Kavita Sharma
Publikováno v: Circulation. 147:1147-1161
Background: The human heart primarily metabolizes fatty acids, and this decreases as alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with severe obesity and diabetes are thought to have increased myocardia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e2ba39d954a029d31a1a4477d47ae3a
https://doi.org/10.1161/circulationaha.122.061846
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5
Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta
Autor: Elizabeth L. Chou, Mark Chaffin, Bridget Simonson, James P. Pirruccello, Amer-Denis Akkad, Mahan Nekoui, Christian Lacks Lino Cardenas, Kenneth C. Bedi, Craig Nash, Dejan Juric, James R. Stone, Eric M. Isselbacher, Kenneth B. Margulies, Carla Klattenhoff, Patrick T. Ellinor, Mark E. Lindsay
Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 42(11)
Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that promote extracellular matrix destruction and structural weakening. To explore this biology, we analyzed the transcriptional features of thoracic aortic tissue. Meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d009632f8ded07226137cbf90be56f08
https://pubmed.ncbi.nlm.nih.gov/36200445
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6
Noncanonical Form of ERAD Regulates Cardiac Hypertrophy
Autor: Erik A. Blackwood, Lauren F. MacDonnell, Donna J. Thuerauf, Alina S. Bilal, Victoria B. Murray, Kenneth C. Bedi, Kenneth B. Margulies, Christopher C. Glembotski
Publikováno v: Circulation. 147:66-82
Background: Cardiac hypertrophy increases demands on protein folding, which causes an accumulation of misfolded proteins in the endoplasmic reticulum (ER). These misfolded proteins can be removed by the adaptive retrotranslocation, polyubiquitylation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be5b66d89dd5e7acac0ec7e53554090
https://doi.org/10.1161/circulationaha.122.061557
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7
Akademický článek
Noncanonical WNT Activation in Human Right Ventricular Heart Failure
Autor: Jonathan J. Edwards, Jeffrey Brandimarto, Dong-Qing Hu, Sunhye Jeong, Nora Yucel, Li Li, Kenneth C. Bedi, Shogo Wada, Danielle Murashige, Hyun Tae V. Hwang, Mingming Zhao, Kenneth B. Margulies, Daniel Bernstein, Sushma Reddy, Zoltan Arany
Publikováno v: Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Background: No medical therapies exist to treat right ventricular (RV) remodeling and RV failure (RVF), in large part because molecular pathways that are specifically activated in pathologic human RV remodeling remain poorly defined. Murine models ha
Externí odkaz: https://doaj.org/article/73b70bc22b134e9492def4bd02201ff2
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8
Akademický článek
Fear of cancer recurrence trajectory during radiation treatment and follow-up into survivorship of patients with breast cancer
Autor: Y. Yang, J. Cameron, C. Bedi, G. Humphris
Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Fear of cancer recurrence (FCR) has been shown to be higher in patients treated with external beam radiotherapy (RT) compared to those untreated. However, little is known about the dynamics of patient’s FCR during and after RT.
Externí odkaz: https://doaj.org/article/e6adc41697c14a5c9250a93f387176c3
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10
Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration
Autor: Edgar E Nollet, Inez Duursma, Anastasiya Rozenbaum, Moritz Eggelbusch, Rob C I Wüst, Stephan A C Schoonvelde, Michelle Michels, Mark Jansen, Nicole N van der Wel, Kenneth C Bedi, Kenneth B Margulies, Jeff Nirschl, Diederik W D Kuster, Jolanda van der Velden
Publikováno v: Nollet, E E, Duursma, I, Rozenbaum, A, Eggelbusch, M, Wüst, R C I, Schoonvelde, S A C, Michels, M, Jansen, M, van der Wel, N N, Bedi, K C, Margulies, K B, Nirschl, J, Kuster, D W D & van der Velden, J 2023, ' Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration ', European heart journal . https://doi.org/10.1093/eurheartj/ehad028
European heart journal. Oxford University Press
Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitocho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdc2e438828d47bff141acdc72a2c34
https://hdl.handle.net/1871.1/0946409f-827c-4433-af9c-265b50db328c
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Plný text Recenzováno Digitální knihovna AV ČR
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