Zobrazeno 1 - 10
of 437
pro vyhledávání: '"C Bartz"'
Autor:
Anthony E. Kincaid, Nathaniel D. Denkers, Erin E. McNulty, Caitlyn N. Kraft, Jason C. Bartz, Candace K. Mathiason
Publikováno v:
Prion, Vol 18, Iss 1, Pp 94-102 (2024)
Chronic wasting disease (CWD) is a transmissible and fatal prion disease that affects cervids. While both oral and nasal routes of exposure to prions cause disease, the spatial and temporal details of how prions enter the central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/db84cf1ce9474f5592e6a496db8c2459
Autor:
Marc D. Schwabenlander, Jason C. Bartz, Michelle Carstensen, Alberto Fameli, Linda Glaser, Roxanne J. Larsen, Manci Li, Rachel L. Shoemaker, Gage Rowden, Suzanne Stone, W. David Walter, Tiffany M. Wolf, Peter A. Larsen
Publikováno v:
Prion, Vol 18, Iss 1, Pp 72-86 (2024)
Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is
Externí odkaz:
https://doaj.org/article/2bfb0fd4908a4a4c933cc02e9bbf9782
Publikováno v:
mSphere, Vol 9, Iss 12 (2024)
ABSTRACT Inhalation of prions into the nasal cavity is an efficient route of infection. Following inhalation of infectious prions, animals develop disease with a similar incubation period compared with per os exposure, but with greater efficiency. To
Externí odkaz:
https://doaj.org/article/0b4e7deabe9f4bb39cb58f6678541534
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Mammalian prion diseases are infectious neurodegenerative diseases caused by the self-templating form of the prion protein PrPSc. Much evidence supports the hypothesis that prions exist as a mixture of a dominant strain and minor prion strai
Externí odkaz:
https://doaj.org/article/81ca639b60a54c27bbd95e601b616809
Autor:
Sara M. Simmons, Vivianne L. Payne, Jay G. Hrdlicka, Jack Taylor, Peter A. Larsen, Tiffany M. Wolf, Marc D. Schwabenlander, Qi Yuan, Jason C. Bartz
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Prion diseases are untreatable fatal transmissible neurodegenerative diseases that affect a wide range of mammals, including humans, and are caused by PrPSc, the infectious self-templating conformation of the host-encoded protein, PrPC. Prio
Externí odkaz:
https://doaj.org/article/fabacc0053da41418cebd566247c5a13
Autor:
Gregory D. Sweetland, Connor Eggleston, Jason C. Bartz, Candace K. Mathiason, Anthony E. Kincaid
Publikováno v:
Prion, Vol 17, Iss 1, Pp 67-74 (2023)
ABSTRACTPrion diseases are fatal neurologic disorders that can be transmitted by blood transfusion. The route for neuroinvasion following exposure to infected blood is not known. Carotid bodies (CBs) are specialized chemosensitive structures that det
Externí odkaz:
https://doaj.org/article/3c90af0db7c34e84b7ea33809ddecdfb
Autor:
Dong Hwan Kim, Jaehyeon Kim, Hakmin Lee, Dongyun Lee, So Myoung Im, Ye Eun Kim, Miryeong Yoo, Yong-Pil Cheon, Jason C. Bartz, Young-Jin Son, Eun-Kyoung Choi, Yong-Sun Kim, Jae-Ho Jeon, Hyo Shin Kim, Sungeun Lee, Chongsuk Ryou, Tae-gyu Nam
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Prions are infectious protein particles known to cause prion diseases. The biochemical entity of the pathogen is the misfolded prion protein (PrPSc) that forms insoluble amyloids to impair brain function. PrPSc interacts with the non-pathogenic, cell
Externí odkaz:
https://doaj.org/article/1fe3e8bdff3a416d802cf6eccfe45604
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Synthetic prions, generated de novo from minimal, non-infectious components, cause bona fide prion disease in animals. Transmission of synthetic prions to hosts expressing syngeneic PrPC results in extended, variable incubation periods and i
Externí odkaz:
https://doaj.org/article/4b8aefa4aa9b4019a521dd10acf81e9e
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011632 (2023)
Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting numerous mammalian species, including Sapiens. Prions are composed of PrPSc, the disease specific conformation of the host encoded prion protein. Prion strains are o
Externí odkaz:
https://doaj.org/article/d0be852e849b414c812358735bc2fef9
Autor:
Jason C. Bartz, Rebeca Benavente, Byron Caughey, Sonja Christensen, Allen Herbst, Edward A. Hoover, Candace K. Mathiason, Debbie McKenzie, Rodrigo Morales, Marc D. Schwabenlander, Daniel P. Walsh, the NC1209: North American Interdisciplinary Chronic Wasting Disease Research Consortium Members
Publikováno v:
Pathogens, Vol 13, Iss 2, p 138 (2024)
Chronic wasting disease (CWD) is a prion disease affecting cervid species, both free-ranging and captive populations. As the geographic range continues to expand and disease prevalence continues to increase, CWD will have an impact on cervid populati
Externí odkaz:
https://doaj.org/article/df96aa46f88041169a047db0e64694f9