Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease

Autor: Erica S. Modeste, Lingyan Ping, Caroline M. Watson, Duc M. Duong, Eric B. Dammer, Erik C. B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)

Abstract Background Despite being twice as likely to get Alzheimer’s disease (AD), African Americans have been grossly underrepresented in AD research. While emerging evidence indicates that African Americans with AD have lower cerebrospinal fluid

Externí odkaz: https://doaj.org/article/7b366553a40942d589b546c51e93941a

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome

Autor: Eric B. Dammer, Lingyan Ping, Duc M. Duong, Erica S. Modeste, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Erik C. B. Johnson

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-32 (2022)

Abstract Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) a

Externí odkaz: https://doaj.org/article/d36b9309b38043c9a11b599f276e3a19

Batch correction and harmonization of –Omics datasets with a tunable median polish of ratio

Autor: Eric B. Dammer, Nicholas T. Seyfried, Erik C. B. Johnson

Publikováno v: Frontiers in Systems Biology, Vol 3 (2023)

Large scale −omics datasets can provide new insights into normal and disease-related biology when analyzed through a systems biology framework. However, technical artefacts present in most −omics datasets due to variations in sample preparation,

Externí odkaz: https://doaj.org/article/04d70e67843d42299e64ea6b4e5a49b5

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

Autor: Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop, Lennart Mucke

Publikováno v: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-26 (2020)

Abstract Background Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precise mechanisms remain

Externí odkaz: https://doaj.org/article/241e604b9e154d01b93f232dcc4d0aa4

CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels

Autor: Marta del Campo, Carel F. W. Peeters, Erik C. B. Johnson, Lisa Vermunt, Yanaika S. Hok-A-Hin, Mirrelijn van Nee, Alice Chen-Plotkin, David J. Irwin, William T. Hu, James J. Lah, Nicholas T. Seyfried, Eric B. Dammer, Gonzalo Herradon, Lieke H. Meeter, John van Swieten, Daniel Alcolea, Alberto Lleó, Allan I. Levey, Afina W. Lemstra, Yolande A. L. Pijnenburg, Pieter J. Visser, Betty M. Tijms, Wiesje M. van der Flier, Charlotte E. Teunissen

Publikováno v: Nature aging, 2(11), 1040-+. Nature Publishing Group
del Campo, M, Peeters, C F W, Johnson, E C B, Vermunt, L, Hok-A-Hin, Y S, van Nee, M, Chen-Plotkin, A, Irwin, D J, Hu, W T, Lah, J J, Seyfried, N T, Dammer, E B, Herradon, G, Meeter, L H, van Swieten, J, Alcolea, D, Lleó, A, Levey, A I, Lemstra, A W, Pijnenburg, Y A L, Visser, P J, Tijms, B M, van der Flier, W M & Teunissen, C E 2022, ' CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels ', Nature Aging, vol. 2, no. 11, pp. 1040-1053 . https://doi.org/10.1038/s43587-022-00300-1
Nature Aging, 2(11), 1040-1053
Nature Aging, 2(11), 1040-1053. Springer
Nature Aging 2 (2022) 11

Development of disease-modifying therapies against Alzheimer's disease (AD) requires biomarkers reflecting the diverse pathological pathways specific for AD. We measured 665 proteins in 797 cerebrospinal fluid (CSF) samples from patients with mild co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64014f96208ce99010397e1041993783
https://doi.org/10.1038/s43587-022-00300-1