Výsledky vyhledávání - "C B, Verchere"

AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects

Autor: Nazde Edeer, C. B. Verchere, Jessica K. Fox, Timothy J. Kieffer, Adam Ramzy, Sarah L. Gray, Maria M. Glavas, James D. Johnson, Derek L. Dai, Robert K. Baker, Shannon O'Dwyer, Xiaoke Hu, Majid Mojibian, Eva Tudurí, Heather C. Denroche

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

In vivo genetic manipulation is used to study the impact of gene deletion or re-expression on β-cell function and organism physiology. Cre-LoxP is a system wherein LoxP sites flanking a gene are recognized by Cre recombinase. Cre transgenic mice are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40d7925c5badbaa5085c2f664e05028
http://link.springer.com/article/10.1038/s41598-020-67136-w

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Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients

Autor: Kathryn J. Potter, Galina Soukhatcheva, Yi-Chun Chen, L. P. Pallo, A. M. Klimek-Abercrombie, M. Bellin, C. B. Verchere, D. Lei

Autologous pancreatic islet transplantation is an established therapy for patients with chronic pancreatitis. However, the long-term transplant outcomes are modest. Identifying indicators of graft function will aid the preservation of transplanted is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cd20eb3046beec3cc061fb144cbb45a
https://doi.org/10.1101/2021.10.17.464749

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A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes

Autor: Karin Breu, Heather Denroche, Melania Osto, C. B. Verchere, François Pattou, Christoph Hock, Jan Grimm, Fabrice Heitz, Julien Thevenet, Ioana Combaluzier, Fabian Wirth, Paolo Arosio, Thomas A. Lutz, Christine Seeger, Roger M. Nitsch, Julie Kerr-Conte, Marc Y. Donath

In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated forms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::952a93f7a1a78a328b53d1974486a1e8
https://doi.org/10.21203/rs.3.rs-147509/v1

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365-OR: The NLRP3 Inflammasome Mediates Early Beta-Cell Dysfunction Triggered by Islet Amyloid

Autor: Nahae Kim, C. B. Verchere, Kiana Yau, Paul C. Orban, Heather C. Denroche, Dominika Nackiewicz, Imelda W. Suen

Publikováno v: Diabetes. 68

Islet amyloid, formed by islet amyloid polypeptide (IAPP) aggregates, may be a trigger of islet inflammation in T2D. In vitro studies using bone marrow-derived macrophages suggest roles for Toll-like receptor 2 (TLR2), and the NLRP3 inflammasome in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb3783d164ba7d2cd2fc1009fc6f4226
https://doi.org/10.2337/db19-365-or

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250-OR: Beta-Cell Rest Induced by Dapagliflozin Improves ß-Cell Secretory Capacity in Type 2 Diabetes Patients: A Randomized Controlled Trial vs. Gliclazide

Autor: Mark H.H. Kramer, Max Nieuwdorp, C. B. Verchere, Michaël J.B. van Baar, Daniël H. van Raalte, Erik J.M. van Bommel, Marcel H.A. Muskiet

Publikováno v: Diabetes. 68

Introduction: Disease progression in type 2 diabetes (T2D) is due to a continuous loss of β-cell function, partly driven by chronic secretory stress on remaining islets caused by hyperglycemia. Beta-cell loss may be further enhanced by insulin secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a6f35f85a90366fb8ddc4c46104853b
https://doi.org/10.2337/db19-250-or

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Amyloid Formation in Human Islets Is Enhanced by Heparin and Inhibited by Heparinase

Autor: D. Lei, C. B. Verchere, Jose Oberholzer, Garth L. Warnock, Isa Werner, Joel Montane, Kathryn J. Potter, Paul E. Fraser, Heather C. Denroche, Y.S. Chen, Galina Soukhatcheva, Annette Plesner

Publikováno v: American Journal of Transplantation. 15:1519-1530

Islet transplantation is a promising therapy for patients with diabetes, but its long-term success is limited by many factors, including the formation of islet amyloid deposits. Heparin is employed in clinical islet transplantation to reduce clotting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101393cebd00e79acf3359572f36a4e0
https://doi.org/10.1111/ajt.13134

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Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

Autor: P. H. C. Kremer, Liam R. Brunham, C. B. Verchere, Michael R. Hayden, L. Dai, Janine K. Kruit, Piers Ruddle, Renmei Tang, W. de Haan

Publikováno v: Diabetologia. 53:1110-1119

Cellular cholesterol accumulation is an emerging mechanism for beta cell dysfunction in type 2 diabetes. Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18cdd9d6b7513f8f155865796af3203
https://doi.org/10.1007/s00125-010-1691-2

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Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

Autor: Kathryn J. Potter, Sakeneh Zraika, C. B. Verchere, Steven E. Kahn, Anna Clark, Daniel P. Raleigh, Paul E. Fraser, Rebecca L. Hull

Publikováno v: Diabetologia. 53:1046-1056

Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the majority of patients. Amyloid formation is considered a significant factor in deterioration of islet function and reduction in beta cell mass, and involves aggreg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b43d638f19914d27b052271ea4fc49b
https://doi.org/10.1007/s00125-010-1671-6

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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

Autor: Jose Oberholzer, Miles Driscoll, Massimo Trucco, Robert K. Baker, Kathryn J. Potter, Peter Marek, Andisheh Abedini, Suzanne Bertera, Paul E. Fraser, Daniel P. Raleigh, Melanie R. Nilsson, Gregory S. Korbutt, C. B. Verchere, Garth L. Warnock, S. Butterworth, Agnieszka M. Klimek

Publikováno v: Proceedings of the National Academy of Sciences. 107:4305-4310

Islet transplantation is a promising treatment for diabetes but long-term success is limited by progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) promote beta cell apoptosis and rapid amyloid formation occur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38ab75f119f82d4085d4ab1a39b7031
https://doi.org/10.1073/pnas.0909024107

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