Zobrazeno 1 - 10
of 38
pro vyhledávání: '"C B, Siegall"'
Publikováno v:
The Journal of Immunology. 159:5168-5173
Immunotoxins have shown promise as antitumor agents in clinical trials. However, they have not become part of standard cancer therapy because of factors that include their inherent immunogenicity, which limits the duration of therapy. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a1e389a1f743d49e3c0000cbf17fe61
https://doi.org/10.4049/jimmunol.159.10.5168
https://doi.org/10.4049/jimmunol.159.10.5168
Publikováno v:
The Journal of Immunology. 157:1652-1658
G28-5 sFv-PE40 is a single-chain immunotoxin that is cytotoxic toward malignant B cells expressing CD40. Human monocytes, which also express cell surface CD40, were found to be insensitive to the immunotoxin. Activation of the monocytic cell line THP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::310198f743cd9e0f0fc66d463db505d1
https://doi.org/10.4049/jimmunol.157.4.1652
https://doi.org/10.4049/jimmunol.157.4.1652
Autor:
C B Siegall, D Chace, B Mixan, U Garrigues, H Wan, L Paul, E Wolff, I Hellström, K E Hellström
Publikováno v:
The Journal of Immunology. 152:2377-2384
BR96 sFv-PE40 is a single-chain immunotoxin fusion protein targeted to the Ley Ag, which is expressed in many different human carcinomas as well as in normal gastrointestinal epithelium of humans and certain animals, including athymic rats but not mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39176a15c99c9c88732300eb0fd6bc6
https://doi.org/10.4049/jimmunol.152.5.2377
https://doi.org/10.4049/jimmunol.152.5.2377
Publikováno v:
The Journal of Immunology. 150:3054-3061
We have constructed a single-chain immunotoxin consisting of the variable H and L chains of the carcinoma-reactive mAb BR96, fused to the binding defective protein toxin, PE40. This molecule, BR96 sFv-PE40, has been shown to be extremely cytotoxic to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b91ec1e1292edc89165308679680fdc2
https://doi.org/10.4049/jimmunol.150.7.3054
https://doi.org/10.4049/jimmunol.150.7.3054
Publikováno v:
Circulation Research. 71:640-645
The dominant mechanism responsible for restenosis after angioplasty is believed to be the activation of medial smooth muscle cells (SMCs), leading to their proliferation, migration to the subintima, and further proliferation. To develop novel strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519eac55c5ebc4fba998e5a837db813c
https://doi.org/10.1161/01.res.71.3.640
https://doi.org/10.1161/01.res.71.3.640
Autor:
B Barlogie, Joshua Epstein, Robert J. Kreitman, C. B. Siegall, Ira Pastan, Desmond J. Fitzgerald
Publikováno v:
Blood. 79:1775-1780
IL-6-PE4E is a recombinant protein consisting of interleukin-6 (IL-6) fused to a mutant form of Pseudomonas exotoxin in which four basic amino acids are changed to glutamate (PE4E). The chimeric toxin has been previously shown to specifically kill ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42a2bbfba5001f4ba28669b8bd6b3582
https://doi.org/10.1182/blood.v79.7.1775.1775
https://doi.org/10.1182/blood.v79.7.1775.1775
Publikováno v:
Biochemistry. 30:7154-7159
Pseudomonas exotoxin (PE) contains 613 amino acids that are arranged into 3 structural domains. PE exerts its cell-killing effects in a series of steps initiated by binding to the cell surface and internalization into endocytic vesicles. The toxin is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be28472da01f88156976a748293b716
https://doi.org/10.1021/bi00243a016
https://doi.org/10.1021/bi00243a016
Publikováno v:
Blood. 77:587-593
It has been reported recently that freshly isolated human myeloma cell cultures proliferate in response to added interleukin-6 (IL-6). Endogenous levels of IL-6 found in the same cultures suggested that an autocrine growth loop may contribute to cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c175144ba5b17e16b92166cc080f00a5
https://doi.org/10.1182/blood.v77.3.587.bloodjournal773587
https://doi.org/10.1182/blood.v77.3.587.bloodjournal773587
Publikováno v:
Journal of Biological Chemistry. 265:16318-16323
The chimeric toxin IL6-PE40, which is composed of interleukin 6 (IL6) fused to a mutant form of Pseudomonas exotoxin (PE) devoid of its native cell recognition domain, can kill myeloma and hepatoma cells which express high levels of IL6 receptors. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6082c9760d1134561fbe5fa7912cba6e
https://doi.org/10.1016/s0021-9258(17)46225-9
https://doi.org/10.1016/s0021-9258(17)46225-9
Publikováno v:
Molecular and Cellular Biology. 10:2443-2447
IL6-PE40 is a chimeric toxin composed of human interleukin-6 (IL6) linked by a peptide bond to PE40, a form of Pseudomonas exotoxin (PE) devoid of its cell recognition domain. To identify cancer cell lines with high numbers of IL6 receptors and to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96be8ac847df2bf46f1f32860b413a6
https://doi.org/10.1128/mcb.10.6.2443-2447.1990
https://doi.org/10.1128/mcb.10.6.2443-2447.1990