Zobrazeno 1 - 10
of 54
pro vyhledávání: '"C B, Roes"'
Autor:
A. R. Müller, B. den Hollander, P. M. van de Ven, K. C. B. Roes, L. Geertjens, H. Bruining, C. D. M. van Karnebeek, F. E. Jansen, M. C. Y. de Wit, L. W. ten Hoopen, A. B. Rietman, B. Dierckx, F. A. Wijburg, E. Boot, M. M. G. Brands, A. M. van Eeghen
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Many rare genetic neurodevelopmental disorders (RGNDs) are characterized by intellectual disability (ID), severe cognitive and behavioral impairments, potentially diagnosed as a comorbid autism spectrum disorder or attention-defic
Externí odkaz:
https://doaj.org/article/4f74098acbcb4b4a96235bd2a74ca971
The Trial within Cohorts (TwiCs) study design in oncology: experience and methodological reflections
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract A Trial within Cohorts (TwiCs) study design is a trial design that uses the infrastructure of an observational cohort study to initiate a randomized trial. Upon cohort enrollment, the participants provide consent for being randomized in futu
Externí odkaz:
https://doaj.org/article/f7590c96266346c9905b0b87394ae947
Autor:
Jeroen H. A. Creemers, Ankur Ankan, Kit C. B. Roes, Gijs Schröder, Niven Mehra, Carl G. Figdor, I. Jolanda M. de Vries, Johannes Textor
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Late-stage cancer immunotherapy trials often lead to unusual survival curve shapes, like delayed curve separation or a plateauing curve in the treatment arm. It is critical for trial success to anticipate such effects in advance and adjust t
Externí odkaz:
https://doaj.org/article/e3acd50fd4b54c859df232a022fd9f30
Autor:
Sean W. Willemse, Kit C. B. Roes, Philip Van Damme, Orla Hardiman, Caroline Ingre, Monica Povedano, Naomi R. Wray, Marleen Gijzen, Mirjam S. de Pagter, Koen C. Demaegd, Annemarie F. C. Janse, Roel G. Vink, Boudewijn T. H. M. Sleutjes, Adriano Chiò, Philippe Corcia, Evy Reviers, Ammar Al-Chalabi, Matthew C. Kiernan, Leonard H. van den Berg, Michael A. van Es, Ruben P. A. van Eijk
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Given the large genetic heterogeneity in amyotrophic lateral sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis identified that patients homozygous for the
Externí odkaz:
https://doaj.org/article/30fbd5e916074b949d8c09f8b72ea468
Autor:
Jules M. Janssen Daalen, Marjan J. Meinders, Federica Giardina, Kit C. B. Roes, Bas C. Stunnenberg, Soania Mathur, Philip N. Ainslie, Dick H. J. Thijssen, Bastiaan R. Bloem
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease, for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based therapy might have short- and long-term benefits in PD. We pre
Externí odkaz:
https://doaj.org/article/e444660f0b144644abab9ac05a31d6ee
Autor:
Raymond Stegeman, Maaike Nijman, Johannes M. P. J. Breur, Floris Groenendaal, Felix Haas, Jan B. Derks, Joppe Nijman, Ingrid M. van Beynum, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Willem A. Helbing, Willem P. de Boode, Arend F. Bos, Rolf M. F. Berger, Ryan E. Accord, Kit C. B. Roes, G. Ardine de Wit, Nicolaas J. G. Jansen, Manon J. N. L. Benders, on behalf of the CRUCIAL trial consortium
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in adverse neurodevelopment. To date, no therapy is available to impro
Externí odkaz:
https://doaj.org/article/ea3a6def0eb44ba2822fd4ebc76f4f4a
Autor:
A. R. Müller, J. R. Zinkstok, N. N. J. Rommelse, P. M. van de Ven, K. C. B. Roes, F. A. Wijburg, E. de Rooij-Askes, C. Linders, E. Boot, A. M. van Eeghen
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-9 (2021)
Abstract Background Smith–Magenis syndrome (SMS) is a rare genetic neurodevelopmental disorder characterized by intellectual disability and severe behavioural and sleep disturbances. Often, patients with SMS are diagnosed with attention-deficit/hyp
Externí odkaz:
https://doaj.org/article/03b44b1eb7904c2fa1d440f9de3bc076
Autor:
Ali Sarrami-Foroushani, Toni Lassila, Michael MacRaild, Joshua Asquith, Kit C. B. Roes, James V. Byrne, Alejandro F. Frangi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In-silico trials rely on virtual populations and interventions simulated using patient-specific models and may offer a solution to lower costs. Here, the authors present the flow diverter performance assessment in-silico trial, which models the treat
Externí odkaz:
https://doaj.org/article/2e882a4a293141e88a26a43c0ba14cb2
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background An estimand defines the target of estimation for a clinical trial through specification of the treatment, target population, variable, population-level summary and of the strategies for intercurrent events. A carefully defined est
Externí odkaz:
https://doaj.org/article/09faba66e8f7413fbb1128d509495be4
Autor:
Ruben P A van Eijk, Anita Beelen, Esther T Kruitwagen, Deirdre Murray, Ratko Radakovic, Esther Hobson, Liam Knox, Jochem Helleman, Tom Burke, Miguel Ángel Rubio Pérez, Evy Reviers, Angela Genge, Frederik J Steyn, Shyuan Ngo, John Eaglesham, Kit C B Roes, Leonard H van den Berg, Orla Hardiman, Christopher J McDermott
Publikováno v:
Journal of Medical Internet Research, Vol 23, Iss 9, p e28766 (2021)
Despite recent and potent technological advances, the real-world implementation of remote digital health technology in the care and monitoring of patients with motor neuron disease has not yet been realized. Digital health technology may increase the
Externí odkaz:
https://doaj.org/article/4eaeac49fb7e4270b5a96f17f524d2c2