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Elastogenesis in the developing chick lung is transcriptionally regulated

Autor: M F, James, C B, Rich, V, Trinkaus-Randall, J, Rosenbloom, J A, Foster

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 213(2)

The overall goals of this study were to establish the level at which elastin gene expression is regulated during chick lung embryogenesis and to identify the temporal and spatial relationships among elastogenesis, smooth muscle cell differentiation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6e26c1db1a93805e8e475aa5c948324
https://pubmed.ncbi.nlm.nih.gov/9786417

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Degradation and repair of elastic fibers in rat lung interstitial fibroblast cultures

Autor: S M, Morris, K M, Thomas, C B, Rich, P J, Stone

Publikováno v: The Anatomical record. 250(4)

Evidence from in vitro and in vivo studies indicates that damaged elastic fibers can be repaired.Lipid interstitial pulmonary fibroblasts were cultured for 6 weeks. Cultures were then exposed to 25 microg of porcine pancreatic elastase and fixed in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49a8fff6a0d00bcb404e1203c8b01119
https://pubmed.ncbi.nlm.nih.gov/9566529

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Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription

Autor: K J, Conn, C B, Rich, D E, Jensen, M R, Fontanilla, M M, Bashir, J, Rosenbloom, J A, Foster

Publikováno v: The Journal of biological chemistry. 271(46)

Previous studies have demonstrated that insulin-like growth factor-I (IGF-I) increases elastin gene transcription in aortic smooth muscle cells and that this up-regulation is accompanied by a loss of protein binding to the proximal promoter. Sp1 has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5da80020d299b31ea7bf0f54442ec3b
https://pubmed.ncbi.nlm.nih.gov/8910531

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Elastase release of basic fibroblast growth factor in pulmonary fibroblast cultures results in down-regulation of elastin gene transcription. A role for basic fibroblast growth factor in regulating lung repair

Autor: C B, Rich, M A, Nugent, P, Stone, J A, Foster

Publikováno v: The Journal of biological chemistry. 271(38)

We have reported previously that a factor released by elastase treatment of pulmonary fibroblast cultures is capable of down-regulating elastin gene expression. In the present study we have pursued the identification of the factor released by elastas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8474dac3f25c95b03ef52092d9c3d60b
https://pubmed.ncbi.nlm.nih.gov/8798493

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Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cells

Autor: D E, Jensen, C B, Rich, A J, Terpstra, S R, Farmer, J A, Foster

Publikováno v: The Journal of biological chemistry. 270(12)

We have recently identified a novel element (EFE 5/6) in the human elastin gene promoter that modulates the ability of insulin-like growth factor I (IGF-I) to up-regulate elastin gene transcription in aortic smooth muscle cells. In the present study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac54e133954432d3ffdbdb742cb59db7
https://pubmed.ncbi.nlm.nih.gov/7896792

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Insulin-like growth factor-I regulates transcription of the elastin gene

Autor: B L, Wolfe, C B, Rich, H D, Goud, A J, Terpstra, M, Bashir, J, Rosenbloom, G E, Sonenshein, J A, Foster

Publikováno v: The Journal of biological chemistry. 268(17)

Neonatal rat aortic smooth muscle cell cultures were used to investigate the mechanisms by which insulin-like growth factor-I (IGF-I) up-regulates aortic elastogenesis. The addition of IGF-I (50 ng/ml) to quiescent smooth muscle cell cultures resulte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::291bfb2d7a8ca91bca24e3c7a99454e5
https://pubmed.ncbi.nlm.nih.gov/8509381

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