Regulation of insulin secretion from novel engineered insulinoma cell lines

Autor: H. E. Hohmeier, H. BeltrandelRio, S. A. Clark, R. Henkel-Rieger, K. Normington, C. B. Newgard

Publikováno v: Diabetes. 46:968-977

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75927f67d98e098c90db7423b1fb07ac
https://doi.org/10.2337/diabetes.46.6.968

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion

Autor: J. W. Joseph, M. V. Jensen, O. Ilkayeva, F. Palmieri, C. Alárcon, C. J. Rhodes, C. B. Newgard

Publikováno v: 281 (2006): 35624–32.
info:cnr-pdr/source/autori:J. W. Joseph, M. V. Jensen, O. Ilkayeva, F. Palmieri, C. Alárcon, C. J. Rhodes and C. B. Newgard/titolo:The mitochondrial citrate%2Fisocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion./doi:/rivista:/anno:2006/pagina_da:35624/pagina_a:32/intervallo_pagine:35624–32/volume:281

Glucose-stimulated insulin secretion (GSIS) is mediated in part by glucose metabolism-driven increases in ATP/ADP ratio, but by-products of mitochondrial glucose metabolism also play an important role. Here we investigate the role of the mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ce553d35e0706fb895143cbd374761db
http://www.cnr.it/prodotto/i/12803

Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase

Autor: S, Aiston, K Y, Trinh, A J, Lange, C B, Newgard, L, Agius

Publikováno v: The Journal of biological chemistry. 274(35)

In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels. To establish whether hexose 6-phosphate regulates GK binding to its regulatory protein, we deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::212c0bb3f60b190483d7eea908016423
https://pubmed.ncbi.nlm.nih.gov/10455119

Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis

Autor: P A, Antinozzi, L, Segall, M, Prentki, J D, McGarry, C B, Newgard

Publikováno v: The Journal of biological chemistry. 273(26)

The mechanism by which glucose stimulates insulin secretion from the pancreatic islets of Langerhans is incompletely understood. It has been suggested that malonyl-CoA plays a regulatory role by inhibiting fatty acid oxidation and promoting accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::885f5c1909698484c6eda630c2577a04
https://pubmed.ncbi.nlm.nih.gov/9632669

Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling

Autor: R J, Noel, P A, Antinozzi, J D, McGarry, C B, Newgard

Publikováno v: The Journal of biological chemistry. 272(30)

Insulin secretion from beta cells in the islets of Langerhans can be stimulated by a number of metabolic fuels, including glucose and glyceraldehyde, and is thought to be mediated by metabolism of the secretagogues and an attendant increase in the AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41daa3dbd847ab2333ba7ac40c9e3aac
https://pubmed.ncbi.nlm.nih.gov/9228030