Internalization via Antennapedia protein transduction domain of an scFv antibody toward c‐Myc protein

Autor: Laura Chiossone, C. Avignolo, Valeria Tomati, Inga Bauer, Annalisa Salis, Paola Orecchia, Luca Bagnasco, Silvio Parodi, Barbara Carnemolla, Melchiori A, M. C. Mingari, L. Zardi, B. Biasotti, Dario Neri

Publikováno v: The FASEB Journal. 22:1237-1245

We constructed a single-chain variable fragment miniantibody (G11-scFv) directed toward the transactivation domain of c-Myc, which is fused with the internalization domain Int of Antennapedia at its carboxyl terminus (a cargo-carrier construct). In E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bea5607d15c57b099884479ead07a34
https://doi.org/10.1096/fj.07-8865com

Sequence specific peptidomimetic molecules inhibitors of a protein-protein interaction at the helix 1 level of c-Myc

Autor: Cecilia Balbi, Enrico Millo, Barbara Carnemolla, Lorenzo Tortolina, B. Biasotti, Melchiori A, C. Avignolo, Maria Pia Pescarolo, Paola Barboro, Gianfranco Fassina, Guido Cimoli, Silvio Parodi, Erika Nieddu, Nicoletta Castagnino, Davide Malacarne, Francesca Vasile, M. Mazzei, B. Licheri, Luca Bagnasco, Eligio Patrone, Paola Orecchia, D. Palomba, Cristina D'Arrigo, R. Ponassi, Gianluca Damonte, Stefania Pasa

Publikováno v: The FASEB journal 19 (2005). doi:10.1096/fj.04-2369fje
info:cnr-pdr/source/autori:Nieddu E.; Melchiori A.; Pescarolo M.P.; Avignolo C.; Bagnasco L.; Balbi C.; Barboro P.; Biasotti B.; Carnemolla B.; Castagnino N.; Cimoli G.; Damonte G.; D'Arrigo C.; Fassina G.; Licheri B.; Malacarne D.; Orecchia P.; Palomba D.; Pasa S.; Patrone E.; Ponassi R;Scapolla A.; Tortolina L.; Vasile F.; Mazzei M.; Parodi S./titolo:Sequence specific peptidomimetic molecules inhibitors of a protein-protein interaction at the helix 1 level of c-myc/doi:10.1096%2Ffj.04-2369fje/rivista:The FASEB journal/anno:2005/pagina_da:/pagina_a:/intervallo_pagine:/volume:19

Our work is focused in the broad area of strategies and efforts to inhibit protein - protein interactions. The possible strategies in this field are definitely much more varied than in the case of ATP-pocket inhibitors. In our previous work ( 10), we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991fe79ab46b63cfc8fc5f5ef6189747
http://hdl.handle.net/11567/847098

Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal Antibodies

Autor: Renato Baserga, W E Mercer, C Avignolo

Publikováno v: Molecular and Cellular Biology. 4:276-281

Two monoclonal antibodies against the p53 protein, PAb 122 and 200-47, were microinjected into mammalian cells as a probe to determine the role of the p53 protein in cell proliferation. PAb 122 recognizes the p53 proteins of mouse and human cells but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123d7aa0cc268ca716b6c56060721123
https://doi.org/10.1128/mcb.4.2.276-281.1984

Microinjection of RNA polymerase II corrects the temperature-sensitive defect of tsAF8 cells

Autor: C Avignolo, Erwin Freund, Renato Baserga, W. Edward Mercer, Dieter E. Waechter, C. Mark Riggenbach, Peter M. McGuire

Publikováno v: Molecular and cellular biochemistry. 60(1)

tsAF8 cells are a temperature-sensitive (ts) mutant of BHK cells that arrest in the G1 phase of the cell cycle at the non-permissive temperature of 40.6 degrees C. Previous reports had suggested that the temperature-sensitivity of these cells was bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454b5a462e80c84ee18146caeea6cab4
https://pubmed.ncbi.nlm.nih.gov/6708942

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