Zobrazeno 1 - 10
of 167
pro vyhledávání: '"C Arnold, Spek"'
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but are also central in the
Externí odkaz:
https://doaj.org/article/c5b7c0e436bb4f81b2d2c86b9d92d80e
Autor:
Cansu Tekin, Brendon P. Scicluna, Sophie C. Lodestijn, Kun Shi, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3091-3108 (2021)
Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal‐like cells. This acinar‐to‐ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can eventua
Externí odkaz:
https://doaj.org/article/655bec2113474b9fb2695cc8e9d4dd14
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a grim disease with high mortality rates. Increased macrophage influx in PDAC is a common hallmark and associated with poor prognosis. Macrophages have high cellular plasticity, which can
Externí odkaz:
https://doaj.org/article/73d1e99142ce41bc93e5c3bcd4de4616
Autor:
Leonie Hartl, Pien A. F. Maarschalkerweerd, Joe M. Butler, Xue D. Manz, Victor L. J. L. Thijssen, Maarten F. Bijlsma, JanWillem Duitman, C. Arnold Spek
Publikováno v:
Cells, Vol 11, Iss 21, p 3334 (2022)
Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive human cancers and occurs globally at an increasing incidence. Metastases are the primary cause of cancer-related death and, in the majority of cases, PDAC is accompanied by metastat
Externí odkaz:
https://doaj.org/article/c40525e5847b4102add33b8dc3094fbd
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 390 (2022)
Pancreatic cancer is a devastating disease with the worst outcome of any human cancer. Despite significant improvements in cancer treatment in general, little progress has been made in pancreatic cancer (PDAC), resulting in an overall 5-year survival
Externí odkaz:
https://doaj.org/article/1af5df60d841422e93b396052159a445
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 219 (2022)
Treatment of pancreatic ductal adenocarcinoma (PDAC), a dismal disease with poor survival rates, is hampered by the high prevalence of chemotherapy resistance. Resistance is accompanied by macrophage infiltration into the tumor microenvironment, and
Externí odkaz:
https://doaj.org/article/1c8065e6b82f41c1bf4788f4fc6063fc
Publikováno v:
Cells, Vol 10, Iss 9, p 2233 (2021)
CCAAT/enhancer-binding protein delta (C/EBPδ) is a member of the C/EBP family of transcription factors. According to the current paradigm, C/EBPδ potentiates cytokine production and modulates macrophage function thereby enhancing the inflammatory r
Externí odkaz:
https://doaj.org/article/7ab27c72921a40d9a26295346fef8aea
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1079 (2021)
CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells. Loss of nuclear C/EBPδ in PDAC cells is associated with decrea
Externí odkaz:
https://doaj.org/article/fbc593a762624215b2689b7d8cd45af3
Publikováno v:
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 152-156 (2017)
Background: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limi
Externí odkaz:
https://doaj.org/article/2269142eebfc40d99cda7074ddaeed9f
Autor:
Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel, C. Arnold Spek
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 13-23 (2017)
Abstract Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives the progression and induces the ch
Externí odkaz:
https://doaj.org/article/6e50a7b861c34a498c0aed80d8226043