Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial

Autor: Arun K. Tiwari, Clement C. Zai, C. Anthony Altar, Julie-Anne Tanner, Paige E. Davies, Paul Traxler, James Li, Elizabeth S. Cogan, Matthew T. Kucera, Ana Gugila, Nicole Braganza, Heather Emmerson, Gwyneth Zai, Daniel J. Müller, Robert Levitan, Stefan Kloiber, Zafiris J. Daskalakis, Benicio N. Frey, James M. Bowen, Jean-Eric Tarride, Richard Tytus, Ranjith Chandrasena, Nicholas Voudouris, Valerie H. Taylor, Raymond Tempier, Verinder Sharma, Akshya Vasudev, Peter Dzongowski, Lew Pliamm, Todd Greenspoon, Bryan M. Dechairo, James L. Kennedy

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract The pharmacological treatment of depression consists of stages of trial and error, with less than 40% of patients achieving remission during first medication trial. However, in a large, randomized-controlled trial (RCT) in the U.S. (“GUIDE

Externí odkaz: https://doaj.org/article/40ed16eb2b844f418d55e066132dd8d5

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Autor: Stacie Weninger, Bjorn Sperling, Robert Alexander, Magnus Ivarsson, Fiona M. Menzies, Peter Powchik, Christopher J. Weber, C. Anthony Altar, Ronald G. Crystal, Stephen J. Haggarty, Jeanne Loring, Lisa J. Bain, Maria C. Carrillo

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Abstract As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earlies

Externí odkaz: https://doaj.org/article/aad32129c56e420799a40117763c7ff7

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Autor: Robert Alexander, Lisa J. Bain, Peter Powchik, Maria C. Carrillo, Ronald G. Crystal, Stacie Weninger, Magnus Ivarsson, C. Anthony Altar, Bjorn Sperling, Christopher J. Weber, Fiona M. Menzies, Stephen J. Haggarty, Jeanne F. Loring

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Translational Research & Clinical Interventions

As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earliest biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21360cee9fe532e6bed181a1648baed7
https://doi.org/10.1002/trc2.12090

Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation

Autor: Susan Garavaglia, Andrew G Marshak, Seth Goldfarb, Josiah D. Allen, Joseph M Carhart, Joel G. Winner, Kelly K Parsons, Gabriela Lavezzari, C Anthony Altar, Bryan Dechairo

Publikováno v: Current Medical Research and Opinion. 31:1633-1643

The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24937c500cc7438bee6d343016c97c0
https://doi.org/10.1185/03007995.2015.1063483

F26'GWAS QUALITY SCORE' (GQS) FOR ASSOCIATED REGIONS IN GWAS META-ANALYSES

Autor: Stephan Ripke, Swapnil Awasthi, C. Anthony Altar

Publikováno v: European Neuropsychopharmacology. 29:S1123

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc97fcd1bafc0fcfdca465a5032ebcb6
https://doi.org/10.1016/j.euroneuro.2018.08.106