Zobrazeno 1 - 10
of 37
pro vyhledávání: '"C Andrew Frank"'
Autor:
Bhagaban Mallik, C Andrew Frank
Publikováno v:
eLife, Vol 12 (2023)
A range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.
Externí odkaz:
https://doaj.org/article/038bf1304d964c9f8664989fe023b9c5
Publikováno v:
eLife, Vol 8 (2019)
Synapses and circuits rely on neuroplasticity to adjust output and meet physiological needs. Forms of homeostatic synaptic plasticity impart stability at synapses by countering destabilizing perturbations. The Drosophila melanogaster larval neuromusc
Externí odkaz:
https://doaj.org/article/4f9549e113b54a0385f95ecd90f03291
Autor:
Douglas J Brusich, Ashlyn M Spring, Thomas D James, Catherine J Yeates, Timothy H Helms, C Andrew Frank
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007577 (2018)
Gain-of-function mutations in the human CaV2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substi
Externí odkaz:
https://doaj.org/article/8e84afdcc7674cc9a7d61507fc3ce816
Autor:
Qiuling Li, David A Kellner, Hayden A M Hatch, Tomohiro Yumita, Sandrine Sanchez, Robert P Machold, C Andrew Frank, Nicholas Stavropoulos
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006815 (2017)
Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the functions of these genes are conserved in mammals remain
Externí odkaz:
https://doaj.org/article/62c8ebf23cb44964b955c2cdac45e08b
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005886 (2016)
Forms of homeostatic plasticity stabilize neuronal outputs and promote physiologically favorable synapse function. A well-studied homeostatic system operates at the Drosophila melanogaster larval neuromuscular junction (NMJ). At the NMJ, impairment o
Externí odkaz:
https://doaj.org/article/81e0230539fd4423b895b36ce8a1600e
Autor:
C. Andrew Frank, Noah Armstrong
The ability of synapses to maintain physiological levels of evoked neurotransmission is essential for neuronal stability. A variety of perturbations can disrupt neurotransmission, but synapses often compensate for disruptions and work to stabilize ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21016cdb81eb4a70a0e03c1f51ebd4d0
https://doi.org/10.1101/2022.08.31.506100
https://doi.org/10.1101/2022.08.31.506100
Autor:
BHAGABAN MALLIK, C. Andrew Frank
Publikováno v:
Frontiers in neuroscience. 16
To identify conserved components of synapse function that are also associated with human diseases, we conducted a genetic screen. We used the Drosophila melanogaster neuromuscular junction (NMJ) as a model. We employed RNA interference (RNAi) on sele
Autor:
Catherine J. Yeates, C. Andrew Frank
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Synapses and circuits rely on homeostatic forms of regulation in order to transmit meaningful information. TheDrosophila melanogasterneuromuscular junction (NMJ) is a well-studied synapse that shows robust homeostatic control of function. Most prior
Publikováno v:
Synapse (New York, N.y.)
The ability to adapt to changing internal and external conditions is a key feature of biological systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to counteract perturbations. In the nervous system, homeostatic mecha