Zobrazeno 1 - 10
of 41
pro vyhledávání: '"C Ammälä"'
1. We have studied the electrophysiological properties of cloned ATP-sensitive K+ channels (KATP channels) heterologously expressed in Xenopus oocytes. This channel comprises a sulphonylurea receptor subunit (SUR) and an inwardly rectifying K+ channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67419e4c5e63d7cd7c9a5720a8cd6f91
https://doi.org/10.1113/jphysiol.1997.sp021843
https://doi.org/10.1113/jphysiol.1997.sp021843
A cDNA clone encoding an inwardly-rectifying potassium channel subunit (Kir6.2) was isolated from an insulinoma cDNA library. The mRNA is strongly expressed in brain, skeletal muscle, cardiac muscle and in insulinoma cells, weakly expressed in lung a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ac6a8b95bf8a54539e4ca711391a3
https://ora.ox.ac.uk/objects/uuid:4ec1303a-c463-4514-b616-80911008040d
https://ora.ox.ac.uk/objects/uuid:4ec1303a-c463-4514-b616-80911008040d
Publikováno v:
Archives of disease in childhood. Fetal and neonatal edition. 82(2)
Insulin is synthesised, stored, and secreted from pancreatic beta cells. These are located within the islets of Langerhans, which are distributed throughout the pancreas. Less than 2% of the total pancreas is devoted to an endocrine function. When th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5943c5ad97afe405e2270e702a67888
https://pubmed.ncbi.nlm.nih.gov/10685980
https://pubmed.ncbi.nlm.nih.gov/10685980
Publikováno v:
ResearcherID
Europe PubMed Central
Europe PubMed Central
1. The effects of GTP and Ca2+ on secretion from single pancreatic beta-cells were studied using capacitance measurements as an indicator of exocytosis. 2. GTP or GTP gamma S produced a concentration-dependent increase in cell capacitance in the abse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc3335c911b62ec94b296dc9794081f
http://ora.ox.ac.uk/objects/uuid:6c8df85b-8078-4de7-a1ff-b860c9351722
http://ora.ox.ac.uk/objects/uuid:6c8df85b-8078-4de7-a1ff-b860c9351722
Autor:
Fiona M. Gribble, Paul A. Smith, Rebecca Ashfield, Frances M. Ashcroft, Andrew J. Moorhouse, Peter Proks, B Coles, Stephen J.H. Ashcroft, C Ammälä, H Sakura
Publikováno v:
Nature. 379(6565)
Sulphonylureas are a class of drugs widely used to treat non-insulin-dependent diabetes mellitus. These drugs act by binding to a sulphonylurea receptor (SUR) in the pancreatic beta-cell membrane which inhibits an ATP-sensitive potassium (K-ATP) chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e1cedd9b5748ef4aa941db64ae5f19
http://ora.ox.ac.uk/objects/uuid:50fa55ee-6295-456d-b3cb-0cbdd90e125e
http://ora.ox.ac.uk/objects/uuid:50fa55ee-6295-456d-b3cb-0cbdd90e125e
Autor:
Frances M. Ashcroft, I.C.M. Rowe, Rebecca Ashfield, Peter Proks, Chris T. Bond, Raheela N. Khan, Kevin Lee, T. A. Blair, John P. Adelman, Fiona M. Gribble, C Ammälä, H Sakura, M.J. Ashford
Publikováno v:
FEBS letters. 367(1)
A cDNA clone encoding an inwardly-rectifying K-channel (BIR1) was isolated from insulinoma cells. The predicted amino acid sequence shares 72% identity with the cardiac ATP-sensitive K-channel rcKATP (KATP-1; [6]). The mRNA is expressed in the brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eb073eb1e6c0258b5616a61510b91b
http://ora.ox.ac.uk/objects/uuid:7b226f09-12fc-42c4-8428-631e7d15bf8d
http://ora.ox.ac.uk/objects/uuid:7b226f09-12fc-42c4-8428-631e7d15bf8d
Publikováno v:
Pflugers Archiv : European journal of physiology. 420(1)
Pretreatment of pancreatic beta cells with pertussis toxin resulted in a 30% increase in peak whole-cell Ca2+ currents recorded in the absence of exogenous intracellular guanine nucleotides. Intracellular application of 90 microM GTP[gamma S], by lib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b40af2aa2b27c7adbaeea7ca77ffb69c
https://pubmed.ncbi.nlm.nih.gov/1313169
https://pubmed.ncbi.nlm.nih.gov/1313169
Publikováno v:
Galanin ISBN: 9781349126668
We have investigated the mechanisms underlying galanin-induced inhibition of electrical activity in normal pancreatic β-cells. By applying the perforated-patch whole-cell recording method (nystatin technique) to cultured mouse β-cells, it was possi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f7323a5fa6a5ee6c4d9dec595b06b8
https://doi.org/10.1007/978-1-349-12664-4_17
https://doi.org/10.1007/978-1-349-12664-4_17
Autor:
C Ammälä, Patrik Rorsman, E Renström, Paul A. Smith, K. Bokvist, Frances M. Ashcroft, Peter Proks, Lena Eliasson
Publikováno v:
Europe PubMed Central
ResearcherID
ResearcherID
1. To investigate the mechanisms regulating the reuptake of secretory granule membranes following regulated exocytosis, we have monitored changes in cell capacitance in single pancreatic beta-cells. 2. Membrane retrieval (endocytosis) occurred both i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710ac3e85f38cf4dcb5d61af036f30da
http://europepmc.org/abstract/med/8799897
http://europepmc.org/abstract/med/8799897
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