Zobrazeno 1 - 10
of 890
pro vyhledávání: '"C Ainsworth"'
Autor:
Simon Deycmar, Brendan J. Johnson, Karina Ray, George W. Schaaf, Declan Patrick Ryan, Cassandra Cullin, Brandy L. Dozier, Betsy Ferguson, Benjamin N. Bimber, John D. Olson, David L. Caudell, Christopher T. Whitlow, Kiran Kumar Solingapuram Sai, Emily C. Romero, Francois J. Villinger, Armando G. Burgos, Hannah C. Ainsworth, Lance D. Miller, Gregory A. Hawkins, Jeff W. Chou, Bruno Gomes, Michael Hettich, Maurizio Ceppi, Jehad Charo, J. Mark Cline
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer immunotherapy; but mechanistic data are lacking regarding the comparative molecular
Externí odkaz:
https://doaj.org/article/30efa148afbb4e31af85e684a6b0f213
Autor:
Ritu M. Ramamurthy, Martin Rodriguez, Hannah C. Ainsworth, Jordan Shields, Diane Meares, Colin Bishop, Andrew Farland, Carl D. Langefeld, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionPlacenta-derived mesenchymal cells (PLCs) endogenously produce FVIII, which makes them ideally suited for cell-based fVIII gene delivery. We have previously reported that human PLCs can be efficiently modified with a lentiviral vector enc
Externí odkaz:
https://doaj.org/article/2efcac3f576d49ef8ba1813b06b80b44
Autor:
Robert M. Clancy, Miranda C. Marion, Hannah C. Ainsworth, Miao Chang, Timothy D. Howard, Peter M. Izmirly, Mala Masson, Jill P. Buyon, Carl D. Langefeld
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Anti-SSA/Ro antibodies, while strongly linked to fetal cardiac injury and neonatal rash, can associate with a spectrum of disease in the mother, ranging from completely asymptomatic to overt Systemic Lupus Erythematosus (SLE) or Sjögren’s Syndrome
Externí odkaz:
https://doaj.org/article/bcc621cc037c430b8873a4ca2de1499c
Autor:
Yogita Ghodke-Puranik, Zhongbo Jin, Kip D. Zimmerman, Hannah C. Ainsworth, Wei Fan, Mark A. Jensen, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Carl D. Langefeld, Timothy B. Niewold
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Abstract Background We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-established genetic r
Externí odkaz:
https://doaj.org/article/96e352fc33f345cd81032036828010a0
Autor:
Kendrah Kidd, Petr Vylet’al, Céline Schaeffer, Eric Olinger, Martina Živná, Kateřina Hodaňová, Victoria Robins, Emily Johnson, Abbigail Taylor, Lauren Martin, Claudia Izzi, Sofia C. Jorge, Joaquim Calado, Rosa J. Torres, Karl Lhotta, Dominik Steubl, Daniel P. Gale, Christine Gast, Eva Gombos, Hannah C. Ainsworth, Ying Maggie Chen, Jorge Reis Almeida, Cintia Fernandes de Souza, Catarina Silveira, Rita Raposeiro, Nelson Weller, Peter J. Conlon, Susan L. Murray, Katherine A. Benson, Gianpiero L. Cavalleri, Miroslav Votruba, Alena Vrbacká, Antonio Amoroso, Daniela Gianchino, Gianluca Caridi, Gian Marco Ghiggeri, Jasmin Divers, Francesco Scolari, Olivier Devuyst, Luca Rampoldi, Stanislav Kmoch, Anthony J. Bleyer
Publikováno v:
Kidney International Reports, Vol 5, Iss 9, Pp 1472-1485 (2020)
Introduction: Autosomal dominant tubulo-interstitial kidney disease due to UMOD mutations (ADTKD-UMOD) is a rare condition associated with high variability in the age of end-stage kidney disease (ESKD). The minor allele of rs4293393, located in the p
Externí odkaz:
https://doaj.org/article/8ab1799f3ce441279d9513d18436243b
Autor:
Swapan K. Das, Hannah C. Ainsworth, Latchezar Dimitrov, Hayrettin Okut, Mary E. Comeau, Neeraj Sharma, Maggie C.Y. Ng, Jill M. Norris, Yii-der I. Chen, Lynne E. Wagenknecht, Donald W. Bowden, Fang-Chi Hsu, Kent D. Taylor, Carl D. Langefeld, Nicholette D. Palmer
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101342- (2021)
Objective: Identify and characterize circulating metabolite profiles associated with adiposity to inform precision medicine. Methods: Untargeted plasma metabolomic profiles in the Insulin Resistance Atherosclerosis Family Study (IRASFS) Mexican Ameri
Externí odkaz:
https://doaj.org/article/1b6c0a5707c340ee89b7191753cae8d7
Autor:
Elaheh Rahbar, Charlotte Mae K. Waits, Edward H. Kirby, Leslie R. Miller, Hannah C. Ainsworth, Tao Cui, Susan Sergeant, Timothy D. Howard, Carl D. Langefeld, Floyd H. Chilton
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-10 (2018)
Abstract Background Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with
Externí odkaz:
https://doaj.org/article/1d93396ab236470f9d3d691a852104e2
Autor:
Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp
Externí odkaz:
https://doaj.org/article/a68227bc3ba0457486591e4743061bf9
Autor:
Elaheh Rahbar, Hannah C Ainsworth, Timothy D Howard, Gregory A Hawkins, Ingo Ruczinski, Rasika Mathias, Michael C Seeds, Susan Sergeant, James E Hixson, David M Herrington, Carl D Langefeld, Floyd H Chilton
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0180903 (2017)
Genetic variants near and within the fatty acid desaturase (FADS) cluster are associated with polyunsaturated fatty acid (PUFA) biosynthesis, levels of several disease biomarkers and risk of human disease. However, determining the functional mechanis
Externí odkaz:
https://doaj.org/article/6ec17c84d7ad4e4fac0d84c1dfa70594
Autor:
NICHOLETTE ALLRED, HANNAH C. AINSWORTH, XIUQING GUO, ADRIENNE W. MACKAY, FESTUS NYASIMI, OWEN MELIA, YANYU LIANG, DONALD W. BOWDEN, KENT TAYLOR, LESLIE J. RAFFEL, THOMAS A. BUCHANAN, RICHARD M. WATANABE, JEROME I. ROTTER, LYNNE E. WAGENKNECHT, CARL D. LANGEFELD, HAE K. IM
Publikováno v:
Diabetes. 71
Diabetes is characterized by metabolic dysregulation. Metabolomics captures interactions of cellular processes and environmental exposures to promote disease and can improve mechanistic understanding to identify clinically relevant targets. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27361d86ac67a0aa96be953fc9d04260
https://doi.org/10.2337/db22-140-or
https://doi.org/10.2337/db22-140-or