Zobrazeno 1 - 10
of 69
pro vyhledávání: '"C Adrian, Shuttleworth"'
Autor:
C. Adrian Shuttleworth, Rawshan Choudhury, Amanda McGovern, Maybo Chiu, Shazia S. Chaudhry, Teresa Massam-Wu, Andrew K. Baldwin, Cay M. Kielty, Clair Baldock
Publikováno v:
Journal of Cell Science. 123:3006-3018
Control of the bioavailability of the growth factor TGFbeta is essential for tissue formation and homeostasis, yet precisely how latent TGFbeta is incorporated into the extracellular matrix is unknown. Here, we show that deposition of a large latent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a92c88782aaa46461a0840f22cfe6cd
https://doi.org/10.1242/jcs.073437
https://doi.org/10.1242/jcs.073437
Publikováno v:
Biochemical Journal
Using human MSCs (mesenchymal stem cells) lacking VEGF (vascular endothelial growth factor) receptors, we show that the pro-angiogenic receptor neuropilin-1 associates with phosphorylated PDGFRs [PDGF (platelet-derived growth factor) receptors], ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f53179389c578f24c412d5f0aa2e8b
http://europepmc.org/articles/PMC3441150
http://europepmc.org/articles/PMC3441150
Publikováno v:
International Journal of Experimental Pathology. 82:295-302
Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2d3d91809393422d5f9be51284631b
https://doi.org/10.1046/j.1365-2613.2001.00201.x
https://doi.org/10.1046/j.1365-2613.2001.00201.x
Publikováno v:
Journal of Cellular and Molecular Medicine
There is now accumulating evidence that bone marrow-derived mesenchymal stem cells (MSCs) make an important contribution to postnatal vasculogenesis, especially during tissue ischaemia and tumour vascularization. Identifying mechanisms which regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148c28f99080d2724754a856738f624e
https://doi.org/10.1111/j.1582-4934.2007.00120.x
https://doi.org/10.1111/j.1582-4934.2007.00120.x
Autor:
Daniel V. Bax, C. Adrian Shuttleworth, Kieran T. Mellody, Cay M. Kielty, Lyle J. Freeman, Amanda Lomas
Publikováno v:
Biochemical Journal. 405:417-428
Fibulin-5, an extracellular matrix glycoprotein expressed in elastin-rich tissues, regulates vascular cell behaviour and elastic fibre deposition. Recombinant full-length human fibulin-5 supported primary human aortic SMC (smooth-muscle cell) attachm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be893c8e7a3bb4c330630c82254bae13
https://doi.org/10.1042/bj20070400
https://doi.org/10.1042/bj20070400
Autor:
Sarah L. Dallas, C. Adrian Shuttleworth, Stuart A. Cain, Amanda Morgan, Shazia S. Chaudhry, Cay M. Kielty
Publikováno v:
The Journal of Cell Biology
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0026180054f9f0c48b78d5bf543799
https://doi.org/10.1083/jcb.200608167
https://doi.org/10.1083/jcb.200608167
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 39:379-391
Smooth muscle alpha-actin filaments are a defining feature of mesenchymal stem cells, and of mesenchyme-derived contractile smooth muscle cells, pericytes and myofibroblasts. Here, we show that adult bone marrow-derived mesenchymal stem cells express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e1b18ba1ccb0ed840db63389bf3b0
https://doi.org/10.1016/j.biocel.2006.09.005
https://doi.org/10.1016/j.biocel.2006.09.005
Autor:
Martin J. Humphries, Richard A. Black, Neill J. Turner, Michael O. Murphy, C. Adrian Shuttleworth, Cay M. Kielty, Michael J. Walker, Ann E. Canfield
Publikováno v:
Circulation. 114:820-829
Background— Essential to tissue-engineered vascular grafts is the formation of a functional endothelial monolayer capable of resisting the forces of blood flow. This study targeted α 2 (VIII) collagen, a major component of the subendothelial matri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b58639138dc25dd67bfbc2e0ce1d3560
https://doi.org/10.1161/circulationaha.106.635292
https://doi.org/10.1161/circulationaha.106.635292
Autor:
C. Adrian Shuttleworth, Stuart A. Cain, Anthony S. Weiss, John T. Gallagher, Amanda Morgan, Cay M. Kielty, Daniel V. Bax, Clair Baldock
Publikováno v:
Journal of Biological Chemistry. 280:30526-30537
Fibrillin-1 assembly into microfibrils and elastic fiber formation involves interactions with glycosaminoglycans. We have used BIAcore technology to investigate fibrillin-1 interactions with heparin and with heparin saccharides that are analogous to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b57b524dbef9a491eeacf8e4d1097870
https://doi.org/10.1074/jbc.m501390200
https://doi.org/10.1074/jbc.m501390200
Autor:
Kieran T. Mellody, C. Adrian Shuttleworth, Lyle J. Freeman, Andrew Marson, Stuart A. Cain, Matthew J. Rock, Amanda Morgan, Cay M. Kielty, Anthony S. Weiss
Publikováno v:
Journal of Biological Chemistry. 279:23748-23758
We have investigated the molecular basis of elastic fiber formation on fibrillin microfibrils. Binding assays revealed high affinity calcium-independent binding of two overlapping fibrillin-1 fragments (encoded by central exons 18-25 and 24-30) to tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e44941203bd285b2589da1e07953f206
https://doi.org/10.1074/jbc.m400212200
https://doi.org/10.1074/jbc.m400212200