Zobrazeno 1 - 10
of 997
pro vyhledávání: '"C A Wolf"'
Publikováno v:
Open Biology, Vol 14, Iss 10 (2024)
The development of therapies to combat neurodegenerative diseases is widely recognized as a research priority. Despite recent advances in understanding their molecular basis, there is a lack of suitable early biomarkers to test selected compounds and
Externí odkaz:
https://doaj.org/article/d1dbb0041ec14212ba7468adda3c1fe0
Autor:
Alice De Carli, Yury Kapelyukh, Jochen Kursawe, Mark A. J. Chaplain, C. Roland Wolf, Sara Hamis
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract In vertical inhibition treatment strategies, multiple components of an intracellular pathway are simultaneously inhibited. Vertical inhibition of the BRAFV600E–MEK-ERK signalling pathway is a standard of care for treating BRAFV600E-mutated
Externí odkaz:
https://doaj.org/article/bd96a413a31b4c50bfa1a5b58b0a3841
Publikováno v:
F1000Research, Vol 11 (2023)
Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of any toxicit
Externí odkaz:
https://doaj.org/article/4f72140abb334804840501cce82da888
Publikováno v:
F1000Research, Vol 11 (2023)
Drug development is an expensive and time-consuming process, with only a small fraction of drugs gaining regulatory approval from the often many thousands of candidates identified during target validation. Once a lead compound has been identified and
Externí odkaz:
https://doaj.org/article/d82d9e4c5b4745c0b592a1aeb131c23f
Autor:
Elena V. Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, Colin J. Henderson, C. Roland Wolf, Julian L. Griffin, Albena T. Dinkova-Kostova
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Knatko et al. examined the importance of Nrf2 activity in the development of colorectal adenomas by performing genetic and pharmacological analyses. The authors found that Keap1 knockdown and Nrf2 activation impacted the metabolism of the non-tumoral
Externí odkaz:
https://doaj.org/article/7c780740b0f74743a3772c55d2dbaca7
Publikováno v:
F1000Research, Vol 11 (2022)
Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of any toxicit
Externí odkaz:
https://doaj.org/article/e964a7dceca745aea0ecb59b8acb1ad2
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Low back pain (LBP) is one of the most common musculoskeletal disorders, causing significant personal and social burden. Current research is focused on the processes of the central nervous system (particularly the sensorimotor sys
Externí odkaz:
https://doaj.org/article/19c1a811d6c84d26bb508b3904a85d12
Autor:
Cheryl van de Wetering, Allison M. Manuel, Mona Sharafi, Reem Aboushousha, Xi Qian, Cuixia Erickson, Maximilian MacPherson, Garrett Chan, Ian M. Adcock, Nazanin ZounematKermani, Florence Schleich, Renaud Louis, Eric Bohrnsen, Angelo D'Alessandro, Emiel F. Wouters, Niki L. Reynaert, Jianing Li, C. Roland Wolf, Colin J. Henderson, Lennart K.A. Lundblad, Matthew E. Poynter, Anne E. Dixon, Charles G. Irvin, Albert van der Vliet, Jos L. van der Velden, Yvonne M. Janssen-Heininger
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102160- (2021)
Background: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice and disruption of pyruvate kinase M2 (PKM2) activity is critical herein. Glutathione-S-transferase P (GSTP) has been implicated in asthma pathogenesi
Externí odkaz:
https://doaj.org/article/15b547ec2ffe4663b0ec95d01314240a
Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]
Autor:
Shogo Takahashi, Tatsuki Fukami, Yusuke Masuo, Chad N. Brocker, Cen Xie, Kristopher W. Krausz, C. Roland Wolf, Colin J. Henderson, Frank J. Gonzalez
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2130-2137 (2016)
Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate. Mice a
Externí odkaz:
https://doaj.org/article/b492e5b921554905ba4d7d1bcb88606c
Figure S1: Quantitative analysis of the immunoblots of Fig 1B. Figure S2: Quantitative analysis of the immunoblots of Fig 1C. Figure S3: Beta-gal staining of brain sections from an untreated p21 reporter mouse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bfac636457245c76bbff7335f7d2a6
https://doi.org/10.1158/1541-7786.22512147.v1
https://doi.org/10.1158/1541-7786.22512147.v1
