Zobrazeno 1 - 10
of 130
pro vyhledávání: '"C A Siebert"'
Autor:
James M. Parkhurst, Adam D. Crawshaw, C. Alistair Siebert, Maud Dumoux, C. David Owen, Pedro Nunes, David Waterman, Thomas Glen, David I. Stuart, James H. Naismith, Gwyndaf Evans
Publikováno v:
IUCrJ, Vol 10, Iss 3, Pp 270-287 (2023)
Three-dimensional electron diffraction (3DED) from nanocrystals of biological macromolecules requires the use of very small crystals. These are typically less than 300 nm-thick in the direction of the electron beam due to the strong interaction betwe
Externí odkaz:
https://doaj.org/article/e0f2750b21824a2da2eac4a6e181c76f
Autor:
Maud Dumoux, Thomas Glen, Jake LR Smith, Elaine ML Ho, Luis MA Perdigão, Avery Pennington, Sven Klumpe, Neville BY Yee, David Andrew Farmer, Pui YA Lai, William Bowles, Ron Kelley, Jürgen M Plitzko, Liang Wu, Mark Basham, Daniel K Clare, C Alistair Siebert, Michele C Darrow, James H Naismith, Michael Grange
Publikováno v:
eLife, Vol 12 (2023)
Serial focussed ion beam scanning electron microscopy (FIB/SEM) enables imaging and assessment of subcellular structures on the mesoscale (10 nm to 10 µm). When applied to vitrified samples, serial FIB/SEM is also a means to target specific structur
Externí odkaz:
https://doaj.org/article/fbc6e73bd5344bb9801714368bad32dd
Autor:
Olivia X. Ma, Wen Guan Chong, Joy K. E. Lee, Shujun Cai, C. Alistair Siebert, Andrew Howe, Peijun Zhang, Jian Shi, Uttam Surana, Lu Gan
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
In meiosis, cells undergo two sequential rounds of cell division, termed meiosis I and meiosis II. Textbook models of the meiosis I substage called pachytene show that nuclei have conspicuous 100-nm-wide, ladder-like synaptonemal complexes and ordere
Externí odkaz:
https://doaj.org/article/b7d434add7484171a99034f77fcfd162
Autor:
James M. Parkhurst, Maud Dumoux, Mark Basham, Daniel Clare, C. Alistair Siebert, Trond Varslot, Angus Kirkland, James H. Naismith, Gwyndaf Evans
Publikováno v:
Open Biology, Vol 11, Iss 10 (2021)
In cryo-electron tomography (cryo-ET) of biological samples, the quality of tomographic reconstructions can vary depending on the transmission electron microscope (TEM) instrument and data acquisition parameters. In this paper, we present Parakeet, a
Externí odkaz:
https://doaj.org/article/70cf5223a322452fb78cf19561387825
Autor:
David C. B. Siebert, Roman Sommer, Domen Pogorevc, Michael Hoffmann, Silke C. Wenzel, Rolf Müller, Alexander Titz
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2922-2929 (2019)
The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis. Mutasynthesis is a promi
Externí odkaz:
https://doaj.org/article/7b6c682e0adb4e48a02cbe71b43e090e
Autor:
Xenia Simeone, David C. B. Siebert, Konstantina Bampali, Zdravko Varagic, Marco Treven, Sabah Rehman, Jakob Pyszkowski, Raphael Holzinger, Friederike Steudle, Petra Scholze, Marko D. Mihovilovic, Michael Schnürch, Margot Ernst
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric GABA-gated chloride channels that are, in mammalians, drawn from a repertoire of 19 different genes, namely α1-6, β1-3, γ1-3, δ, ε, θ, π and ρ1-3. The existence of this wid
Externí odkaz:
https://doaj.org/article/46343707d7194d3e987086a53ab6033f
Autor:
Matthew S. Proctor, Lorna A. Malone, David A. Farmer, David J.K. Swainsbury, Frederick R. Hawkings, Federica Pastorelli, Thomas Z. Emrich-Mills, C. Alistair Siebert, C. Neil Hunter, Matthew P. Johnson, Andrew Hitchcock
Publikováno v:
Biochemical Journal. 479:1487-1503
In oxygenic photosynthesis, the cytochrome b6f (cytb6f) complex links the linear electron transfer (LET) reactions occurring at photosystems I and II and generates a transmembrane proton gradient via the Q-cycle. In addition to this central role in L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe1cbcac355f2b8ac39a665bf08a48
https://doi.org/10.1042/bcj20220124
https://doi.org/10.1042/bcj20220124
Autor:
David J. K. Swainsbury, Frederick R. Hawkings, Elizabeth C. Martin, Sabina Musiał, Jack H. Salisbury, Philip J. Jackson, David A. Farmer, Matthew P. Johnson, C. Alistair Siebert, Andrew Hitchcock, C. Neil Hunter
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cytochrome bc 1 complexes are ubiquinol:cytochrome c oxidoreductases, and as such, they are centrally important components of respiratory and photosynthetic electron transfer chains in many species of bacteria and in mitochondria. The minimal complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fefd464b52cda5f50529ef78cf70a5
https://doi.org/10.1073/pnas.2217922120
https://doi.org/10.1073/pnas.2217922120
Autor:
Irina Bregy, Julika Radecke, Akira Noga, Hugo van den Hoek, Mara Kern, Beat Haenni, Benjamin D. Engel, C. Alistair Siebert, Takashi Ishikawa, Benoît Zuber, Torsten Ochsenreiter
In contrast to many eukaryotic organisms, trypanosomes only contain a single mitochondrion per cell. Within that singular mitochondrion, the protist carries a single mitochondrial genome that consists of a complex DNA network, the kinetoplast DNA (kD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1625a3135cc8a81355734eaeeba4f670
https://doi.org/10.1101/2023.03.06.531305
https://doi.org/10.1101/2023.03.06.531305
Autor:
Maud Dumoux, Thomas Glen, Jake LR Smith, Elaine ML Ho, Luis MA Perdigão, Avery Pennington, Sven Klumpe, Neville BY Yee, David Andrew Farmer, Pui YA Lai, William Bowles, Ron Kelley, Jürgen M Plitzko, Liang Wu, Mark Basham, Daniel K Clare, C Alistair Siebert, Michele C Darrow, James H Naismith, Michael Grange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d771b0ab21da6c07ba6e75f1abff440
https://doi.org/10.7554/elife.83623.sa2
https://doi.org/10.7554/elife.83623.sa2