Zobrazeno 1 - 10
of 18
pro vyhledávání: '"C A Romerdahl"'
Autor:
M J Pérez de Vega, Qian Xiao-Dong, M. Moran, J M Castellano, Gerhard Keilhauer, C A Romerdahl, M. F. Brana
Publikováno v:
European Journal of Medicinal Chemistry. 30:235-239
Summary A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the pre
Publikováno v:
The Journal of Immunology. 144:1382-1386
A mouse/human chimeric antibody (ch14.18) was developed that reacts with the disialoganglioside GD2 on the surface of tumor cells of neuroectodermal origin. ch14.18 has the constant regions of a human IgG1 antibody and was expressed in a murine hybri
Autor:
M F, Braña, J M, Castellano, M, Morán, M J, Pérez de Vega, D, Perron, D, Conlon, P F, Bousquet, C A, Romerdahl, S P, Robinson
Publikováno v:
Anti-cancer drug design. 11(4)
The bis-naphthalimides are a new class of antitumor agent. Previously, we have described initial synthetic series which established that two naphthalimide chromophores joined by polyamine linkers can produce agents with antitumor activity. We now ext
Autor:
M F, Braña, J M, Castellano, M, Morán, M J, Pérez de Vega, C R, Romerdahl, X D, Qian, P, Bousquet, F, Emling, E, Schlick, G, Keilhauer
Publikováno v:
Anti-cancer drug design. 8(4)
A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was s
Publikováno v:
Cancer research. 51(8)
The human melanoma cell line M24met metastasizes spontaneously from s.c. tumors to multiple distant sites in mice with severe combined immunodeficiency. Metastasis to lymph nodes and lungs is found in 100% of the animals. M24met has an undifferentiat
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 144(4)
A mouse/human chimeric antibody (ch14.18) was developed that reacts with the disialoganglioside GD2 on the surface of tumor cells of neuroectodermal origin. ch14.18 has the constant regions of a human IgG1 antibody and was expressed in a murine hybri
Publikováno v:
Anti-Cancer Drugs. 5:37
Autor:
C A Romerdahl, M L Kripke
Publikováno v:
The Journal of Immunology. 137:3031-3035
The purpose of this study was to determine the role of T helper (Th) cells in the immune response to UV-induced tumors. Repeated exposure of mice to UV radiation results in the production of suppressor T lymphocytes that facilitate tumor growth by in
Autor:
C A, Romerdahl, H, Rubin
Publikováno v:
Journal of the National Cancer Institute. 74(6)
Cells from a cloned line of spontaneously transformed 3T3 cells had a colony-forming efficiency in agar (CFEag) of about 10-15% and induced poorly differentiated sarcomas when injected into nude mice. These tumor cells were recultured in vitro and te
Autor:
C A, Romerdahl, H, Rubin
Publikováno v:
Cancer research. 44(12 Pt 1)
A subline of cloned spontaneously transformed BALB/3T3 cells had a colony-forming efficiency (CFE) in agar of 5 to 20%. Individual agar colonies isolated and reseeded into agar were not significantly more efficient at initiating colonies than the ori