Zobrazeno 1 - 10
of 211
pro vyhledávání: '"C A Mcclung"'
Autor:
Li Deng, Baibai Gao, Lun Zhao, Ying Zhang, Qing Zhang, Minrong Guo, Yongqing Yang, Shuangqi Wang, Liang Xie, Hao Lou, Meng Ma, Wei Zhang, Zhilin Cao, Qinghua Zhang, C. Robertson McClung, Guoliang Li, Xingwang Li
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background The daily cycling of plant physiological processes is speculated to arise from the coordinated rhythms of gene expression. However, the dynamics of diurnal 3D genome architecture and their potential functions underlying the rhythm
Externí odkaz:
https://doaj.org/article/30006cc2886d4cddbd3ba01381b5f283
294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models
Autor:
John Smith, Stefan Husted, Jay Pilrose, Disha Kuchangi, Stephanie C. Ems-McClung, Richard L. Carpenter, Claire E. Walczak
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 88-88 (2023)
OBJECTIVES/GOALS: Microtubule poisons, like Taxol, are used to treat triple negative breast cancer (TNBC) and may induce lethal aneuploidy in cancer cells. Patients initially respond, but often develop drug resistance. New targeted drugs that cause a
Externí odkaz:
https://doaj.org/article/f7ae9f0c09394593a916ba7b9b8be76b
Autor:
Chong Zhang, Min Gao, Nicholas C. Seitz, William Angel, Amelia Hallworth, Linda Wiratan, Omar Darwish, Nadim Alkharouf, Teklu Dawit, Daniela Lin, Riki Egoshi, Xiping Wang, C. Robertson McClung, Hua Lu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Circadian control of plant defence likely reflects plants’ ability to coordinate development and defense. Here, Zhang et al. show that LUX regulates stomatal defense and SA/JA signaling, leading to broad-spectrum disease resistance, and that JA sig
Externí odkaz:
https://doaj.org/article/bb6bac1b66ec4e1a924a9aa50b18f152
Autor:
Kathleen Greenham, Ryan C Sartor, Stevan Zorich, Ping Lou, Todd C Mockler, C Robertson McClung
Publikováno v:
eLife, Vol 9 (2020)
An important challenge of crop improvement strategies is assigning function to paralogs in polyploid crops. Here we describe the circadian transcriptome in the polyploid crop Brassica rapa. Strikingly, almost three-quarters of the expressed genes exh
Externí odkaz:
https://doaj.org/article/6685cdefe91d408e8bc3125a40c30f23
Autor:
Byoung-Doo Lee, Mi Ri Kim, Min-Young Kang, Joon-Yung Cha, Su-Hyun Han, Ganesh M. Nawkar, Yasuhito Sakuraba, Sang Yeol Lee, Takato Imaizumi, C. Robertson McClung, Woe-Yeon Kim, Nam-Chon Paek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
CONSTANS promotes flowering under long-day conditions in Arabidopsis but is rapidly degraded in short-day conditions. Here the authors show that the blue-light photoreceptor FKF1 can interact with the E3 ligase COP1 in a light-dependent manner and pr
Externí odkaz:
https://doaj.org/article/1a478ef286c24896982e14447d7abbad
Autor:
Walczak, John C. Smith, Stefan Husted, Jay Pilrose, Stephanie C. Ems-McClung, Jane R. Stout, Richard L. Carpenter, Claire E.
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3309
Standard of care for triple-negative breast cancer (TNBC) involves the use of microtubule poisons such as paclitaxel, which are proposed to work by inducing lethal levels of aneuploidy in tumor cells. While these drugs are initially effective in trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::2feeca250e033e8e9bef5455bd51af5f
Importin α/β promote Kif18B microtubule association and enhance microtubule destabilization activity
Autor:
Sanjay Shrestha, Stephanie C. Ems-McClung, Mark A. Hazelbaker, Amber L. Yount, Sidney L. Shaw, Claire E. Walczak
Publikováno v:
Molecular Biology of the Cell. 34
The critical regions of interaction between the Kif18B tail and its binding partners, importin α/β and EB1, are defined, and it is shown how these interactions control Kif18B function in cells and activity in vitro. A new mechanism is uncovered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374b394f8812d20720ca8592f644e1bf
https://doi.org/10.1091/mbc.e22-03-0113
https://doi.org/10.1091/mbc.e22-03-0113
Autor:
Kathleen Greenham, Carmela Rosaria Guadagno, Malia A Gehan, Todd C Mockler, Cynthia Weinig, Brent E Ewers, C Robertson McClung
Publikováno v:
eLife, Vol 6 (2017)
The dynamics of local climates make development of agricultural strategies challenging. Yield improvement has progressed slowly, especially in drought-prone regions where annual crop production suffers from episodic aridity. Underlying drought respon
Externí odkaz:
https://doaj.org/article/39f4312931c74f04951e35a271212bc1
Autor:
C. Robertson McClung
Publikováno v:
Biology, Vol 8, Iss 1, p 14 (2019)
It has been nearly 300 years since the first scientific demonstration of a self-sustaining circadian clock in plants. It has become clear that plants are richly rhythmic, and many aspects of plant biology, including photosynthetic light harvesting an
Externí odkaz:
https://doaj.org/article/d8f51b8bc48c4cc2bbd921b709851850
Importin α/β Promote Kif18B Microtubule Association to Spatially Control Microtubule Destabilization
Autor:
Sanjay Shrestha, Stephanie C. Ems-McClung, Mark A. Hazelbaker, Amber L. Yount, Sidney L. Shaw, Claire E. Walczak
Tight regulation of microtubule (MT) dynamics is necessary for proper spindle assembly and chromosome segregation. The MT destabilizing Kinesin-8, Kif18B, controls astral MT dynamics and spindle positioning. Kif18B interacts with importin α/β as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4366b872759257baaa96488c95cbcc86
https://doi.org/10.1101/2022.03.30.486445
https://doi.org/10.1101/2022.03.30.486445
