Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis

Autor: Fleur M. Keij, Bjørn E. V. Koch, Fernando Lozano Vigario, Sinno H. P. Simons, Johan G. C. van Hasselt, H. Rob Taal, C. A. J. Knibbe, Herman P. Spaink, Irwin K. M. Reiss, Elke H. J. Krekels

Publikováno v: Journal of Clinical and Translational Science, Vol 5 (2021)

Neonatal sepsis is a major cause of death and disability in newborns. Commonly used biomarkers for diagnosis and evaluation of treatment response lack sufficient sensitivity or specificity. Additionally, new targets to treat the dysregulated immune r

Externí odkaz: https://doaj.org/article/9924878bb4804dca8344c5a48b18b1e4

Critical appraisal of evidence for anti-Xa monitoring and dosing of low-molecular-weight heparin in renal insufficiency

Autor: M. P. H. van den Broek, Marjon V. Verschueren, C. A. J. Knibbe

Publikováno v: Expert Review of Clinical Pharmacology, 15(10), 1155-1163. TAYLOR & FRANCIS LTD

Introduction: Several guidelines advise to monitor therapeutic LMWH therapy with peak anti-Xa concentrations in renal insufficiency with subsequent dose adjustments. A better understanding of the clinical association between peak anti-Xa concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36322149ee63109a5c901cf2f03dfa5
http://hdl.handle.net/1887/3494154

Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies

Autor: K P van Rhee, S L de Vroom, R M van Hest, P D van der Linden, S H Tonino, E Molendijk, R A A Mathôt, N M A Blijlevens, C A J Knibbe, R J M Bruggemann, S E Geerlings

Publikováno v: Journal of Antimicrobial Chemotherapy, 77, 11, pp. 3069-3076
The Journal of antimicrobial chemotherapy, 77(11), 3069-3076. Oxford University Press
Journal of Antimicrobial Chemotherapy, 77, 3069-3076
Journal of Antimicrobial Chemotherapy, 77(11), 3069-3076. OXFORD UNIV PRESS

Background Patients with haematological malignancies frequently endure neutropenia and gastrointestinal (GI)-mucositis after high-dose chemotherapy. In these patients, ciprofloxacin is used for Gram-negative infection prophylaxis. Objectives We inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37334b498f4033149b8f929dcbaa33cb
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/287859

Population-Based Studies on the Epidemiology of Insulin Resistance in Children

Autor: M. P. van der Aa, S. Fazeli Farsani, C. A. J. Knibbe, A. de Boer, M. M. J. van der Vorst

Publikováno v: Journal of Diabetes Research, Vol 2015 (2015)

Background. In view of the alarming incidence of obesity in children, insight into the epidemiology of the prediabetic state insulin resistance (IR) seems important. Therefore, the aim of this systematic review was to give an overview of all populati

Externí odkaz: https://doaj.org/article/ded954402e1c4c7b99251dfe9e5d5aad

Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates

Autor: Anne Smits, Meindert Danhof, J. de Hoon, Karel Allegaert, R. F. W. De Cock, Veroniek Saegeman, C. A. J. Knibbe

Publikováno v: Journal of Antimicrobial Chemotherapy. 69:1330-1338

OBJECTIVES: Cefazolin is frequently administered for antimicrobial prophylaxis and treatment of infections. In neonates, pharmacokinetic observations are limited and dosing regimens variable. The aim of this study was to describe the pharmacokinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41535c04f8fb098bde981f8eef009c20
https://doi.org/10.1093/jac/dkt527