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Akademický článek

Heat-stress and light-stress induce different cellular pathologies in the symbiotic dinoflagellate during coral bleaching.

Autor: C A Downs, Kathleen E McDougall, Cheryl M Woodley, John E Fauth, Robert H Richmond, Ariel Kushmaro, Stuart W Gibb, Yossi Loya, Gary K Ostrander, Esti Kramarsky-Winter

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e77173 (2013)

Coral bleaching is a significant contributor to the worldwide degradation of coral reefs and is indicative of the termination of symbiosis between the coral host and its symbiotic algae (dinoflagellate; Symbiodinium sp. complex), usually by expulsion

Externí odkaz: https://doaj.org/article/3c6607e92ea2445f9b1d4842dc1884b9

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Akademický článek

Selenium Deficiency Exacerbates Hyperoxia-Induced Lung Injury in Newborn C3H/HeN Mice

Autor: Lora C. Bailey-Downs, Laura G. Sherlock, Michaela N. Crossley, Aristides Rivera Negron, Paul T. Pierce, Shirley Wang, Hua Zhong, Cynthia Carter, Kathryn Burge, Jeffrey V. Eckert, Lynette K. Rogers, Peter F. Vitiello, Trent E. Tipple

Publikováno v: Antioxidants, Vol 13, Iss 4, p 391 (2024)

Extremely preterm infants are often treated with supraphysiological oxygen, which contributes to the development of bronchopulmonary dysplasia (BPD). These same infants exhibit compromised antioxidant capacities due in part to selenium (Se) deficienc

Externí odkaz: https://doaj.org/article/b543f017fbe34d0c89a8920b52ce3959

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AG488 as a therapy against gliomas

Autor: Aleem Gangjee, James Battiste, Lora C. Bailey-Downs, Jake Sutton, Debra Saunders, Rheal A. Towner, Jadith Ziegler, Nataliya Smith, Anja Bastian, Michael A. Ihnat, Megan R. Lerner

Publikováno v: Oncotarget

// Jadith Ziegler 1, 2 , Anja Bastian 3 , Megan Lerner 4 , Lora Bailey-Downs 3 , Debra Saunders 1 , Nataliya Smith 1 , Jake Sutton 1 , James D. Battiste 5 , Michael A. Ihnat 3 , Aleem Gangjee 6 and Rheal A. Towner 1, 2, 3, 5 1 Advanced Magnetic Reson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95be09345423f27229ff45598b2e19de
https://doi.org/10.18632/oncotarget.18284

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A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer

Autor: Ravi Kumar Vyas Devambatla, Aleem Gangjee, Lora C. Bailey-Downs, Kenneth M. Humphries, Michael A. Ihnat, Shraddha S. Vadvalkar, Jim Henthorn, Bryan C. Disch, Jessica E. Thorpe, Anja Bastian

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 353:392-404

Therapy for treatment-resistant breast cancer provides limited options and the response rates are low. Therefore, the development of therapies with alternative chemotherapeutic strategies is necessary. AG311 (5-[(4-methylphenyl)thio]-9H-pyrimido[4,5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f76942de82bd981e90057de30f712446
https://doi.org/10.1124/jpet.114.220335

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17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Autor: Michael B. Stout, Stephen Brimijoin, Willard M. Freeman, Marcelo Rubinstein, Frederik J. Steyn, T. Y. Xie, Martin Ghadami, Malcolm J. Low, Shyuan T. Ngo, Lora C. Bailey-Downs, Vicky Ping Chen

Publikováno v: Aging Cell
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1d3a60474be4717ab8eb3db695106e
https://pubmed.ncbi.nlm.nih.gov/29168299

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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents

Autor: Nicholas F. Dybdal-Hargreaves, Lora C. Bailey-Downs, Susan L. Mooberry, Jessica E. Thorpe, Ernest Hamel, Cristina C. Rohena, Aleem Gangjee, Bryan C. Disch, Michael A. Ihnat, Sudhir Raghavan, Anja Bastian, Xin Zhang

Publikováno v: Bioorganic & Medicinal Chemistry. 22:3753-3772

The design, synthesis and biological evaluations of fourteen 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines are reported. Four compounds (11-13, 15) inhibit vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eefb3b61850e60efc7230f07539f460
https://doi.org/10.1016/j.bmc.2014.04.049

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Discovery of Antitubulin Agents with Antiangiogenic Activity as Single Entities with Multitarget Chemotherapy Potential

Autor: Michael A. Ihnat, Lora C. Bailey-Downs, Anja Bastian, Aleem Gangjee, Jessica E. Thorpe, Rouli Bai, Roheeth Kumar Pavana, Ernest Hamel, Bryan C. Disch

Publikováno v: ACS Medicinal Chemistry Letters. 5:480-484

Antiangiogenic agents (AA) are cytostatic, and their utility in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical combinations of vascular endothelial growth factor receptor-2 (VEGFR2) inhibitors with anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b879da6363853d8597b027d21789608
https://doi.org/10.1021/ml4004793

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N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents

Autor: Aleem Gangjee, Jianming Yu, Jessica E. Thorpe, Ojas A. Namjoshi, Michael A. Ihnat, Lora C. Bailey-Downs

Publikováno v: Bioorganic & Medicinal Chemistry. 21:1312-1323

Six novel N(4)-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines and their N(2)-trimethylacetyl substituted analogs were synthesized as receptor tyrosine kinase (RTK) inhibitors. A microwave-mediated Sonogashira react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a7424bc78c6d84698fe779ca250e06
https://doi.org/10.1016/j.bmc.2012.12.045

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